Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Сен. 18, 2023
Prediction of high-risk events in mental disorder patients is crucial. In our previous study, we developed a deep learning model: DeepBiomarker by using electronic medical records (EMR) to predict suicide related event (SRE) risk post-traumatic stress (PTSD) patients.
Язык: Английский
Neurobiology of Disease, Год журнала: 2024, Номер 199, С. 106598 - 106598
Опубликована: Июль 11, 2024
Myocardial infarction (MI) and depression are leading causes of mortality morbidity globally, these conditions increasing recognized as being fundamentally interconnected. The recently gut-heart-brain axis offers insights into following MI, but effective treatments for this comorbidity remain lacking. To address medical need, we employed an animal model MI to investigate the potential repurposing sotagliflozin (SOTA), approved sodium-glucose cotransporter 1 2 (SGLT1/2) inhibitor diabetes, managing identifying SOTA-associated microbial mechanisms. SOTA treatment improved cardiac dysfunction alleviated depression-like behaviors induced by accompanied alterations in gut microbiota composition, such changes Prevotellaceae NK3B31 group, Alloprevotella, UCG-001. Moreover, fecal transplantation (FMT) using samples from SOTA-treated mice demonstrated that contributed beneficial effects on mice. Intriguingly, FMT-based intervention concordance analysis before after FMT suggested UCG-001 were associated with SOTA. Furthermore, functional prediction correlation support significance dynamic communities. In conclusion, findings suggest could serve a drug ameliorate depressive symptoms patients via through axis.
Язык: Английский
Процитировано
3
Nature Reviews Cardiology, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
Язык: Английский
Процитировано
0
Stress and Health, Год журнала: 2025, Номер 41(2)
Опубликована: Март 22, 2025
ABSTRACT Major depressive disorder (MDD) is a stress‐related disease that affects women more often than men. Music therapy (MT) has been shown to be effective in the treatment of MDD. However, clinical trials investigating effects MT on psychological and psychobiological outcomes suffering from MDD are still scarce. This study was conducted as randomised controlled trial, with participants assigned either an intervention group (IG), which received (GMT), or waitlist control (CG), GMT 6 months later. The primary objective assess impact stress (chronic stress, coping, experienced daily life) markers (diurnal salivary cortisol levels circadian heart rate variability), considering both allocation time. Outcome measurements were taken before, immediately after, and—for some variables—10 weeks following period. A total 102 18–65 years old diagnosed current took part study. Overall, IG demonstrated significantly stronger stress‐reducing CG. Significant improvements observed general positive thinking, life levels. cost‐effective non‐invasive approach effectively address burden associated To demonstrate long‐term gain better understanding underlying mechanisms, further methodologically robust studies needed. Trail Registration MUSED pre‐registered at German Clinical Trials Registry (DRKS00016616). All study‐related procedures published detail protocol.
Язык: Английский
Процитировано
0
Hypertension Research, Год журнала: 2025, Номер unknown
Опубликована: Июнь 3, 2025
Язык: Английский
Процитировано
0
Biomedical Signal Processing and Control, Год журнала: 2023, Номер 86, С. 105315 - 105315
Опубликована: Авг. 14, 2023
Brain–heart interactions involve bidirectional effects produced by bottom-up input at each heartbeat, and top-down neural regulatory responses of the brain. While cortical processing heartbeat is usually investigated through analysis Heartbeat Evoked Potential, in this study we propose an alternative approach based on variability predictability brain dynamics induced heartbeat. In a group eighteen subjects whom simultaneous recording electroencephalogram (EEG) electrocardiogram was performed resting-state, analyzed temporal profile local Information Storage (IS) to detect changes regularity EEG signals time windows associated with different phases cardiac cycle rest. The average values IS were significantly higher parieto-occipital areas scalp, suggesting activation Default Mode Network, regardless phase. contrast, showed marked differences across phases. Our results suggest that activity influences predictive information differently various cycle. measures can represent useful index identify spatio-temporal within neurocardiac system, which generally remain overlooked more widely employed global measures.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12765 - 12765
Опубликована: Ноя. 27, 2024
Stress responses can impact bladder cancer (BC) outcomes via immune–inflammatory pathway modulation. This study explores heart rate variability (HRV) associations with serum biomarkers, blood count inflammatory markers, and psychosocial self-report measures in patients versus healthy controls. The TREM-1 TREM-2 expressions on peripheral monocytes were analysed flow cytometry; biomarkers by ELISA; HRV (5-min ECG) pre-tumour resection; counts haematology analyser; factors validated questionnaires. Patients exhibited altered profiles increased TREM-1/TREM-2, sTREM-1, sTREM-1/sTREM-2 ratio, BDNF, MCP-1, NLR, reduced IFN-γ, IL-10, LMR, PMR. analysis indicated sympathetic dominance (SNS, indices, ACmod) parasympathetic modulation (PNS index, SDNN, RMSSD, 2UV%, DCmod, SD1). Sympathetic indices correlated positively fractalkine, markers (SII, PLR) negatively indices—correlations absent Only patients, physical function social support, higher anxiety, depression, fatigue, associated markers. links parameters, BC, suggesting that immune autonomic variations may relate to unfavourable outcomes. Incorporating these assessments could help tailor more personalised treatment strategies for BC patients.
Язык: Английский
Процитировано
2
Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 358 - 358
Опубликована: Март 10, 2024
Ketamine is a potential rapid-onset antidepressant characterized by sympathomimetic effects. However, the question of ketamine’s use in treating adolescents’ major depressive disorder (MDD) still discussed. Thus, we aimed to study acute effect ketamine infusion treatment on sympathetic regulation using electrodermal activity (EDA) addition an assessment symptomatology MDD adolescents. Twenty hospitalized adolescent girls with (average age: 15.0 ± 1.46 yrs.) were examined before and two hours after single intravenous ketamine. EDA was continuously recorded for 6 min, symptoms assessed administration. The evaluated parameters included skin conductance level (SCL), nonspecific responses (NS-SCRs), MADRS (questions no. 1–10, total score), CDI (items A–E, score). showed no significant changes treatment, significantly reduced infusion. analysis revealed negative correlation between index SCL CDI-A, CDI-E, score NS-SCRs 4 treatment. In conclusion, improved without EDA, indicating its safety efficiency as intervention MDD.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июнь 7, 2023
Abstract Objective Brain-heart interactions involve bidirectional effects produced by bottom-up input at each heartbeat, and top-down neural regulatory responses of the brain. While cortical processing heartbeat is usually investigated through analysis Heartbeat Evoked Potential, in this study we propose an alternative approach based on variability predictability brain dynamics induced heartbeat. Methods In a group eighteen subjects whom simultaneous recording electroencephalogram (EEG) electrocardiogram was performed resting-state, analyzed temporal profile local Information Storage (IS) to detect changes regularity EEG signals time windows associated with different phases cardiac cycle rest. Results The average values IS were significantly higher parieto-occipital areas scalp, suggesting activation Default Mode Network, regardless phase. contrast, showed marked differences across phases. Conclusion Our results suggest that activity influences predictive information differently various cycle. Significance measures can represent useful index identify spatio-temporal within neurocardiac system, which generally remain overlooked more widely employed global measures.
Язык: Английский
Процитировано
1
Frontiers in Psychology, Год журнала: 2023, Номер 14
Опубликована: Авг. 24, 2023
This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional (C-EDS), and antidepressant treatment on mortality due cancer other causes in a community cohort.A community-based sample recruited 1995, 2000, 2005 aged between 35 75 years was examined two waves followed for median 6.7 years. SDS C-EDS phenotypes were assessed using Patient Health Questionnaire-9. Medication used by participants collected. Deaths their registered during follow-up. Cox proportional hazard models stratified sex performed determine mortality.The cohort consisted 5,646 individuals (53.9% women) with mean age 64 (SD = 11.89). During follow-up, 392 deaths recorded, which 27.8% cancer. phenotype associated an increased risk both men (HR 2.23; 95% CI 1.11-4.44) women 3.69; 1.69-8.09), significantly non-cancer 2.16; 95 % 1.46-3.18). Selective serotonin reuptake inhibitors (SSRIs) 2.78; 1.10-6.98) 2.94; 1.76-4.90) only male population.C-EDS related at 6 In addition, use SSRIs population all-cause mortality.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Март 18, 2024
Abstract Depression is a leading worldwide cause of mental disorders and disability, strongly affecting emotional processing regulation. Its dysfunctional psycho-physiological dynamics may be part the nervous-system-wise symptomatology, impacting not only patients’ psyche but also significantly influencing functional cardiovascular dynamics. Therefore, depression serves as an exemplary pathological manifestation interaction between central autonomic nervous systems. While recent literature has been developing specific techniques to quantify such interactions, often referred Brain-Heart Interplay (BHI), quantitative role BHI in largely unknown. This study aims experimentally unveil patterns regulation subjects exhibiting depressive symptoms compared healthy controls. Results were gathered from cohort 72 individuals indicate that are associated with continuous efferent central-to-peripheral hyperactivity afferent peripheral-to-central hypoactivity. hypoactivity appears negative processing. offers novel insights into systemic investigation neuro-physiological bases depression.
Язык: Английский
Процитировано
0