Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 13, 2022
The
identification
of
safe
and
easily-determined-inflight
biomarkers
to
monitor
the
immune
system
astronauts
is
mandatory
ensure
their
well-being
success
missions.
In
this
report,
we
evaluated
relevance
two
whose
determination
could
be
easily
implemented
in
a
spacecraft
near
future
by
using
bedridden
volunteers
as
ground-based
model
microgravity
spaceflight.
Our
data
confirm
neutrophil
lymphocyte
ratio
(NLR)
suggest
platelet
(PLR)
monitoring
assess
long-lasting
diseases.
We
recommend
coupling
these
ratios
other
biomarkers,
such
quantification
cytokines
viral
load
measurements,
efficiently
detect
dysfunction,
determine
when
countermeasures
should
applied
promote
recovery,
prevent
development
disease,
track
responses
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 753 - 753
Опубликована: Янв. 6, 2024
Aging
induces
numerous
physiological
alterations,
with
immunosenescence
emerging
as
a
pivotal
factor.
This
phenomenon
has
attracted
both
researchers
and
clinicians,
prompting
profound
questions
about
its
implications
for
health
disease.
Among
the
contributing
factors,
one
intriguing
actor
in
this
complex
interplay
is
human
cytomegalovirus
(CMV),
member
of
herpesvirus
family.
Latent
CMV
infection
exerts
influence
on
aging
immune
system,
potentially
to
age-related
diseases.
review
delves
into
intricate
relationship
between
CMV,
revealing
how
chronic
viral
impacts
landscape.
We
explore
mechanisms
through
which
can
impact
composition
functionality
cell
populations
induce
shifts
inflammatory
profiles
aging.
Moreover,
we
examine
potential
role
pathologies
such
cardiovascular
diseases,
cancer,
neurodegenerative
disorders,
COVID-19,
Long
COVID.
underlines
importance
understanding
CMV.
It
offers
insights
pathophysiology
age-associated
well
COVID-19
outcomes
among
elderly.
By
unraveling
connections
gain
deeper
aging’s
remarkable
journey
that
infections
play
transforming
system.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15722 - 15722
Опубликована: Дек. 11, 2022
Vascular
diseases
of
the
elderly
are
a
topic
enormous
interest
in
clinical
practice,
as
they
have
great
epidemiological
significance
and
lead
to
ever-increasing
healthcare
expenditures.
The
mechanisms
underlying
these
pathologies
been
increasingly
characterized
over
years.
It
has
emerged
that
endothelial
dysfunction
chronic
inflammation
play
diriment
role
among
most
relevant
pathophysiological
mechanisms.
As
one
can
easily
imagine,
various
processes
occur
during
aging,
several
pathways
undergo
irreversible
alterations
promote
decline
aberrations
trigger
above.
Endothelial
aging
circulating
resident
cells
main
characteristics
aged
organism;
represent
framework
within
which
an
array
molecular
abnormalities
contribute
accelerating
perpetuating
organs
tissues.
Recognizing
detailing
each
dysfunctional
is
helpful
for
therapeutic
purposes,
it
allows
hypothesize
possibility
tailoring
interventions
damaged
mechanism
hypothetically
limiting
cascade
events
drive
onset
diseases.
With
this
paper,
we
reviewed
scientific
literature,
analysing
basis
vascular
pausing
reflect
on
attempts
interrupt
vicious
cycle
connotes
laying
groundwork
reasoning
expanding
field
research
by
moving
from
solid
foundation.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 2, 2023
Multiple
sclerosis
(MS)
primarily
affects
adult
females.
However,
in
the
last
decades,
rising
incidence
and
prevalence
have
been
observed
for
demographic
extremes,
such
as
pediatric-onset
MS
(POMS;
occurring
before
18
years
of
age)
late-onset
(corresponding
to
an
onset
above
50
years).
These
categories
show
peculiar
clinical-pathogenetic
characteristics,
aging
processes
disease
courses,
therapeutic
options,
unmet
needs.
Nonetheless,
several
open
questions
are
still
pending.
POMS
patients
display
important
contribution
multiple
genetic
environmental
factors
EBV,
while
LOMS,
hormonal
changes
pollution
may
represent
triggers.
In
both
categories,
immunosenescence
emerges
a
pathogenic
driver
disease,
particularly
LOMS.
populations,
patient
caregiver
engagement
essential
from
diagnosis
communication
early
treatment
disease-modifying
therapy
(DMTs),
which
elderly
population
appears
more
complex
less
proven
terms
efficacy
safety.
Digital
technologies
(e.g.,
exergames
e-training)
recently
emerged
with
promising
results,
treating
following
motor
cognitive
deficits.
this
offer
seems
feasible
POMS,
being
LOMS
familiar
digital
technology.
narrative
review,
we
discuss
how
process
influences
pathogenesis,
course,
options
Finally,
evaluate
impact
new
tools,
greatly
interest
current
future
management
patients.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 24, 2023
The
process
of
aging
is
accompanied
by
a
dynamic
restructuring
the
immune
response,
phenomenon
known
as
immunosenescence.
This
mini-review
navigates
through
complex
landscape
age-associated
changes,
chronic
inflammation,
age-related
autoimmune
tendencies,
and
their
potential
links
with
immunopathology
Long
COVID.
Immunosenescence
serves
an
introductory
departure
point,
elucidating
alterations
in
cell
profiles
functional
dynamics,
changes
T-cell
receptor
signaling,
cytokine
network
dysregulation,
compromised
regulatory
function.
Subsequent
scrutiny
or
“inflammaging,”
highlights
its
roles
susceptibilities
mediator
perturbations
observed
COVID
patients.
introduction
epigenetic
facets
further
amplifies
interconnections.
In
this
compact
review,
we
consider
interactions
between
immunosenescence,
autoimmunity.
We
aim
to
explore
multifaceted
relationships
that
link
these
processes
shed
light
on
underlying
mechanisms
drive
interconnectedness.
With
focus
understanding
immunological
context
aging,
seek
provide
insights
into
how
immunosenescence
inflammation
contribute
emergence
progression
disorders
elderly
may
serve
for
disturbances.
Abstract
Renal
aging,
marked
by
the
accumulation
of
senescent
cells
and
chronic
low‐grade
inflammation,
leads
to
renal
interstitial
fibrosis
impaired
function.
In
this
study,
we
investigate
role
macrophages,
a
key
regulator
in
aging
analyzing
kidney
single‐cell
RNA
sequencing
data
C57BL/6J
mice
from
8
weeks
24
months.
Our
findings
elucidate
dynamic
changes
proportion
cell
types
during
reveal
that
increased
macrophage
infiltration
contributes
with
these
macrophages
exhibiting
senescence
activation
ferroptosis
signaling.
CellChat
analysis
indicates
enhanced
communications
between
tubular
aging.
Suppressing
alleviates
macrophage‐mediated
partial
epithelial‐mesenchymal
transition
vitro,
thereby
mitigating
expression
fibrosis‐related
genes.
Using
SCENIC
analysis,
infer
Stat1
as
age‐related
transcription
factor
promoting
iron
dyshomeostasis
regulating
Pcbp1,
an
chaperone
protein
inhibits
ferroptosis.
Furthermore,
through
virtual
screening
molecular
docking
library
anti‐aging
compounds,
construct
model
targeting
which
natural
small
molecule
compound
Rutin
can
suppress
preserving
Pcbp1.
summary,
our
study
underscores
crucial
results
also
suggest
Pcbp1
intervention
target
aging‐related
highlight
potential
therapeutic
agent
inflammation
fibrosis.
Aging
is
associated
with
a
progressive
decline
of
innate
and
adaptive
immune
responses,
called
immunosenescence.
This
phenomenon
links
to
different
multiple
sclerosis
(MS)
disease
courses
among
age
groups.
While
clinical
relapse
active
demyelination
are
mainly
related
the
altered
immunity,
including
invasion
T-
B-lymphocytes,
impairment
cell
(e.g.,
microglia,
astrocyte)
function
main
contributor
disability
progression
neurodegeneration.
Most
patients
MS
manifest
relapsing-remitting
phenotype
at
younger
age,
while
phenotypes
seen
in
older
patients.
Current
disease-modifying
therapies
(DMTs)
primarily
targeting
immunity
less
efficacious
patients,
suggesting
that
immunosenescence
plays
role
treatment
response.
review
summarizes
recent
mechanistic
studies
regarding
discusses
implications
these
findings.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 5, 2024
Multiple
Sclerosis
(MS)
management
in
individuals
aged
55
and
above
presents
unique
challenges
due
to
the
complex
interaction
between
aging,
comorbidities,
immunosenescence,
MS
pathophysiology.
This
comprehensive
review
explores
evolving
landscape
of
older
adults,
including
increased
incidence
prevalence
this
age
group,
shift
disease
phenotypes
from
relapsing-remitting
progressive
forms,
presence
multimorbidity
polypharmacy.
We
aim
provide
an
updated
available
evidence
disease-modifying
treatments
(DMTs)
patients,
efficacy
safety
existing
therapies,
emerging
such
as
Bruton
tyrosine
kinase
(BTKs)
inhibitors
those
targeting
remyelination
neuroprotection,
critical
decisions
surrounding
initiation,
de-escalation,
discontinuation
DMTs.
Non-pharmacologic
approaches,
physical
therapy,
neuromodulation
cognitive
rehabilitation,
psychotherapy,
are
also
examined
for
their
role
holistic
care.
The
importance
Care
Units
advance
care
planning
explored
a
cornerstone
providing
patient-centric
care,
ensuring
alignment
with
patient
preferences
trajectory.
Finally,
emphasizes
need
personalized
continuous
monitoring
alongside
advocating
inclusive
study
designs
clinical
research
improve
growing
demographic.
