Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
With
the
term
neuroinflammation
has
defined
typical
inflammatory
response
of
brain
closely
related
to
onset
many
neurological
diseases.
Neuroinflammation
is
well
known,
but
its
mechanisms
and
pathways
are
not
entirely
comprehended.
Currently,
some
progress
been
achieved
through
efforts
research.
Consequently,
new
cellular
molecular
mecha-nisms,
diverse
from
conventional
ones,
emerging.
In
listing
those
that
will
be
sub-ject
our
description
discussion,
essential
important
role
peripheral
infiltrated
monocytes
clonotypic
cells,
alterations
in
gut/brain
axis,
dysregulation
apelinergic
sys-tem,
as
changes
endothelial
glycocalyx
blood-brain
barrier,
variation
expres-sion
genes
levels
encoding
molecules
by
microRNAs
(miRNAs),
or
other
epige-netic
factors
distinctive
transcriptional
factors,
autophagy,
ferroptosis,
sex
differences
modifications
circadian
cycle.
Such
mentioned
can
add
significant
pieces
understanding
complex
etiological
puzzle
neuroinflammation.
addi-tion,
they
could
represent
biomarkers
targets
neurodegenerative
diseases,
increase
old
populations.
Brain Sciences,
Год журнала:
2024,
Номер
14(3), С. 243 - 243
Опубликована: Фев. 29, 2024
Multiple
sclerosis
(MS)
is
a
demyelinating
central
nervous
system
disease
that
leads
to
neurological
disability.
Brain-derived
neurotrophic
factors
(BDNFs)
are
neurotrophins
involved
in
neurodegenerative
disorders.
This
study
analysed
the
relationship
between
serum
BDNF,
disability
and
different
MS
treatments.
We
included
63
people
with
(PwMS),
relapsing-remitting
or
clinically
isolated
syndrome,
16
healthy
controls
(HCs).
levels
of
BDNF
specific
tests
(Expanded
Disability
Status
Scale,
timed
25-foot
walk
test,
nine-hole
peg
test),
at
baseline
(V0)
after
one
year
interferon
beta1a
teriflunomide
treatment
(V1).
Baseline
values
were
not
PwMS
HCs
(p
=
0.85).
The
higher
vs.
0.003).
was
related
last-year
relapses
by
duration
(all
p
>
0.05).
overall
for
decreased
<
0.001).
Both
treatments
implied
similar
reduction.
influenced
lesion
burden,
active
lesions,
new
lesions
on
MRI
In
our
cohort,
had
compared
treatment.
clinical
paraclinical
severity
signs.
Myasthenia
gravis
(MG)
is
a
disease
characterized
by
typical
clinical
and
immunopathogenic
pe-culiarities,
which
correlate
with
age
sex/gender.
Accordingly,
MG
patients
show
thymic
al-terations
auto-antibodies
productions,
that
can
be
the
expression
of
different
pathogenetic
mechanism
related
to
gender.
This
determines,
in
relation
at
sex/gender,
dif-ferent
onset,
prognosis,
outcome.
Therefore,
diverse
forms
identified,
classi-fied,
their
features,
precisely
there
are
early
onset
late-onset
MG.
It
has
been
hypothesized
cause
appearance
two
ascribed
mainly
genetic
epigenetic
factors.
In
this
narrative
review,
we
will
analyze
discuss
about
interplay
age-
sex-related
factors
(i.e.
genet-ic
factors)
how
they
contribute
di-verse
pathogenesis.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
