Oral Microbiota and Porphyromonas Gingivalis Kgp Genotypes Altered in Parkinson’s Disease with Mild Cognitive Impairment DOI Creative Commons
Dongcheng Li, Tengzhu Ren, Hao Li

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 16, 2023

Abstract Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson’s disease (PD), including PD with mild cognitive (PD-MCI) and dementia. Recent studies reported oral dysbiosis CI, respectively. Porphyromonas gingivalis ( P. ), pathogen dysbiosis, play an important role PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No previous study investigated composition microbiota PD-MCI. This aimed investigates differences composition, copy number, Kgp genotypes among PD-MCI, normal cognition(PD-NC) periodontal status-matched control (PC) groups. The bacteria number gingival crevicular fluid from PD-NC, PC were analyzed using 16S ribosomal RNA sequencing, quantitative real-time PCR, MseⅠ restriction. We found that structures PD-MCI group significantly different compared PD-NC group. relative abundances Prevotella , Lactobacillus Megasphaera Atopobium Howardella negatively correlated score. Moreover, there was significant difference three predominant primarily Ⅱ, whereas mainly Ⅰ. Ⅱ lower MMSE MoCA scores, suggested PD-CI may be related Ⅱ.

Язык: Английский

Oral Microbiota and Porphyromonas gingivalis Kgp Genotypes Altered in Parkinson’s Disease with Mild Cognitive Impairment DOI
Dongcheng Li, Tengzhu Ren, Hao Li

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Язык: Английский

Процитировано

8
Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review DOI Creative Commons
Pinja Kettunen, Jari Koıstınaho, Taisia Rõlova

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Июнь 6, 2024

Abstract Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger neuroinflammation which is considered integrally involved in processes. In this review, we will look at data linking variety of viral, bacterial, fungal, and protozoan to Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, multiple sclerosis unspecified dementia. This narrative review aims bring together broad range currently supporting the involvement central development diseases. The idea that no single pathogen or group responsible diseases be discussed. Instead, suggest wide susceptibility factors may make individuals differentially vulnerable different infectious pathogens subsequent pathologies.

Язык: Английский

Процитировано

7
Chaudhuri’s Dashboard of Vitals in Parkinson’s syndrome: an unmet need underpinned by real life clinical tests DOI Creative Commons
Mubasher A. Qamar, Silvia Rota, Lucia Batzu

и другие.

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Май 25, 2023

We have recently published the notion of “vitals” Parkinson’s, a conglomeration signs and symptoms, largely nonmotor, that must not be missed yet often considered in neurological consultations, with considerable societal personal detrimental consequences. This “dashboard,” termed Chaudhuri’s vitals are summarized as 5 key vital symptoms or comprise (a) motor, (b) (c) visual, gut, oral health, (d) bone health falls, finally (e) comorbidities, comedication, dopamine agonist side effects, such impulse control disorders. Additionally, addressing also may reflect inadequate management strategies, leading to worsening quality life diminished wellness, new concept for people Parkinson’s. In this paper, we discuss possible, simple use, clinically relevant tests can used monitor status these vitals, so incorporated into clinical practice. use term Parkinson’s syndrome describe disease, “disease” is now abandoned many countries, U.K., reflecting heterogeneity which by syndrome.

Язык: Английский

Процитировано

11
Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells DOI
Ambika Verma, Gohar Azhar, Pankaj Patyal

и другие.

GeroScience, Год журнала: 2024, Номер 46(5), С. 4315 - 4332

Опубликована: Март 20, 2024

Язык: Английский

Процитировано

4
Parkinson’s disease alters the composition of subgingival microbiome DOI Creative Commons
Ekin Yay, Melis Yılmaz, Hilal Uslu Toygar

и другие.

Journal of Oral Microbiology, Год журнала: 2023, Номер 15(1)

Опубликована: Авг. 28, 2023

The current study aimed to test the hypothesis that Parkinson's disease exacerbates periodontitis by altering its microbiome.Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, patients (PD), and with (PA+PD) analyzed using checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated health. Next-generation sequencing (NGS) of 16S ribosomal RNA gene (V1-V3 regions) was performed analyze microbiome comprehensively.Parkinson's had mild-to-moderate motor dysfunctions. Bleeding on probing significantly increased in PA+PD group compared PD (p < 0.05). With analysis, PA Treponema socranskii = 0.0062), Peptostreptococcaceae_[G-6] [Eubacterium]_nodatum 0.0439), Parvimona micra 0.0001), Prevotella melaninogenica 0.0002), Lachnoanaerobaculum saburreum Streptococcus anginosus 0.0020). intermedia 0.0042), P.nodatum 0.0022), P.micra denticola 0.0045), L.saburreum 0.0267), P.melaninogenica 0.0017), Campylobacter rectus 0.0020), T.socranskii 0.0002) higher; Aggregatibacter actinomycetemcomitans 0.0072) lower deep pockets PD. Schaalia odontolytica 0.0351) A.actinomycetemcomitans 0.002) lower; C.rectus 0065), constellatus 0.0151), T.denticola 0.0141), 0.0057), 0.0316) higher shallow PA+PD. Diversity decreased 0.001) 0.026) control, minimal differences alpha beta diversities among based NGS results.These data demonstrated modifies PD-associated subgingival microbiome.

Язык: Английский

Процитировано

9
Porphyromonas gingivalis exacerbates experimental autoimmune encephalomyelitis by driving Th1 differentiation via ZAP70/NF-κB signaling DOI Creative Commons

Dong Qin Dai,

Guoqin Cao,

Shengyuan Huang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Multiple sclerosis (MS) is characterized by chronic inflammation and demyelination within the central nervous system (CNS), primarily driven abnormal activation of peripheral immune system, notably Th1 cells. As principal pathogen in periodontitis, Porphyromonas gingivalis (P. gingivalis) linked to an increased risk multiple progression; however, its role remains unclear. In this study, we aimed determine whether P. promotes cell differentiation via ZAP70/NF-κB signaling pathway, thereby exacerbating experimental autoimmune encephalomyelitis(EAE), a model sclerosis. C57BL/6J mice were randomly divided into healthy control, EAE, periodontitis with EAE group. Neurological function was assessed using Weaver's score. Histopathology (H&E, LFB staining) Evans blue dye leakage evaluated inflammation, demyelination, blood-brain barrier(BBB)permeability. Th17 cells quantified flow cytometry, while immunofluorescence staining performed analyze Claudin-5, IFN-γ +CD4+ T -positive IL-17+CD4+-positive expression. Western blotting measured NF-κB related protein Reference-based mRNA sequencing analysis Kyoto encyclopedia genes genomes (KEGG) pathway enrichment conducted identify differential gene expression enrichment. encephalomyelitis, infection significantly elevated proportions blood, interferon-gamma expression, exacerbated enhancing barrier permeability. The also activated essential for differentiation, as evidenced p65 nuclear translocation significant upregulation Th1-related genes, including those transcription factor Tbx21 interleukin-12 receptors. vitro, lipopolysaccharide (LPS) stimulated ZAP70/NF-κB, which effectively blocked inhibitors, reducing pro-inflammatory factors. Our findings elucidate, first time, how driving activation. This highlights local contributor neuroinflammation, providing new insights pathogenesis identifying promising targets immunomodulatory therapeutic strategies.

Язык: Английский

Процитировано

0
Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies DOI
Nina P. Trubitsina, Anton B. Matiiv, Tatyana Rogoza

и другие.

Biochemistry (Moscow), Год журнала: 2024, Номер 89(3), С. 523 - 542

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

2
Mechanisms of oral microflora in Parkinson's disease DOI
Bingbing Wang, Can Zhang,

Caizhen Shi

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер 474, С. 115200 - 115200

Опубликована: Авг. 10, 2024

Язык: Английский

Процитировано

2
MAD—microbial (origin of) Alzheimer’s disease hypothesis: from infection and the antimicrobial response to disruption of key copper-based systems DOI Creative Commons
Jin Hong Min, Heela Sarlus, Robert A. Harris

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 2, 2024

Microbes have been suspected to cause Alzheimer’s disease since at least 1908, but this has generally remained unpopular in comparison the amyloid hypothesis and dominance of Aβ Tau. However, evidence accumulating suggest that these earlier theories are a manifestation common can trigger interact with all major molecular players recognized AD. Aβ, Tau ApoE, particular appear be molecules normal homeostatic functions also alternative antimicrobial functions. Their confer non-immune specialized neuron some innate intracellular defenses re-appropriated from their times need. Indeed, signs infection neurons by biofilm-forming microbial colonies, synergy herpes viruses, evident clinical preclinical studies we discuss. Furthermore, attempt provide mechanistic understanding AD landscape discussing effect ApoE Lactoferrin AD, possible link deficiency vital copper-based systems. In particular, focus on mitochondrial oxidative respiration via complex 4 ceruloplasmin for iron homeostasis, how is similar possibly central neurodegenerative diseases general. case (MAD) theory, namely could fact caused long-term exposure or even themselves results costly prolonged response disrupts systems govern neurotransmission, homeostasis respiration. Finally, discuss potential treatment modalities based holistic incorporates many separate seemingly conflicting theories. If MAD theory correct, then reduction through use broad anti-inflammatory treatments potentially alleviate although requires further investigation.

Язык: Английский

Процитировано

2
Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model DOI Open Access
Audrey Mercer,

Marco Sancandi,

Amy MacLatchy

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11168 - 11168

Опубликована: Окт. 17, 2024

The detection of early molecular mechanisms and potential biomarkers in Parkinson’s disease (PD) remains a challenge. Recent research has pointed to novel roles for post-translational citrullination/deimination caused by peptidylarginine deiminases (PADs), family calcium-activated enzymes, the stages disease. current study assessed brain-region-specific citrullinated protein targets their associated protein–protein interaction networks alongside PAD isozymes 6-hydroxydopamine (6-OHDA) induced rat model pre-motor PD. Six brain regions (cortex, hippocampus, striatum, midbrain, cerebellum olfactory bulb) were compared between controls/shams PD model. For all regions, there was significant difference IDs controls. Citrullinated hits most abundant cortex followed cerebellum, bulb striatum. Citrullinome-associated pathway enrichment analysis showed correspondingly considerable differences six regions; some overlapping controls PD, identified only, control brains only. KEGG (Kyoto Encyclopedia Genes Genomes) pathways only with neurological, metabolic, immune hormonal functions included following: “Axon guidance”; “Spinocerebellar ataxia”; “Hippo signalling pathway”; “NOD-like receptor “Phosphatidylinositol system”; “Rap1 “Platelet activation”; “Yersinia infection”; “Fc gamma R-mediated phagocytosis”; “Human cytomegalovirus “Inositol phosphate metabolism”; “Thyroid hormone “Progesterone-mediated oocyte maturation”; “Oocyte meiosis”; “Choline metabolism cancer”. Some furthermore observed five (PADs 1, 2, 3, 4 6), changes 3 when comparing regions. Our findings indicate that PAD-mediated citrullination plays immune, cell neurodegenerative disease-related across highlighting PADs as future therapeutic avenues.

Язык: Английский

Процитировано

2