Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
4
Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)
Опубликована: Март 31, 2025
Язык: Английский
Процитировано
1
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Апрель 29, 2025
It is increasingly recognized that the brain continuously interacts with other body systems such as immune system, gut-brain axis, and endocrine system. Dysfunctions in these can impact mental health by altering neurotransmitter levels neurochemical environment. This shift understanding underscores need for therapeutic strategies address systemic mitochondrial function, alongside psychosocial aspects of disease, offering a more personalized adaptive approach to treatment. study utilizes translational research structured through Work Breakdown Structure methodology, dividing process into six interconnected Packages (WPs). These include systematic literature reviews on dysfunctions hormonal therapies disorders, application Design Thinking neuroendocrine innovation, hypothesis exploration hCG adjunctive treatment psychiatric culminating result dissemination evaluation. The identified multiple mechanistic impacts human chorionic gonadotropin (hCG) relevant Key findings from Hormetic Therapy (HHT) stimulation sex hormone production, reduction insulin resistance inflammation, enhancement hypothalamic activity regulate appetite, sleep, emotions, LH-like effects cognition. HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, reduced dysfunction, restoring cellular function critical health. underscore significance enhancing metabolic functions viable strategy improving care, aligning trends advocate holistic strategies. suggested dose future protocols 500 IU IM per week at least 10 weeks. Supporting diverse varied crucial advancing medical knowledge. Continuous disorders using advanced tools neuroscience, endocrinology, psychiatry provide new pathways effective treatments. offers insights complex interactions, underscoring potential innovative psychiatry.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 2, 2024
Abstract The etiology of tic disorders (TDs) is not precisely known, although several lines evidence suggest involvement the immune system in pathogenesis. Here, we aimed to determine expression levels pro-inflammatory and anti-inflammatory cytokines children with TD compare them those healthy controls. Furthermore, also evaluated their association clinical variables group. Within study period, 88 111 control were enrolled. Most diagnosed Tourette’s disorder (n = 47, 53.4%) or persistent motor 39, 44.3%), while remainder 2, 2.3%) vocal disorder. We found that had significantly elevated IL-1β, TNF-α, IL-6 IL-4 expression, detected lower IL-17 disorders. Our findings provide a molecular landscape cytokine TD, which may proinflammatory state affected by presence comorbidity symptom severity. Delineating contribution alterations pathogenesis pave way for better therapeutic interventions.
Язык: Английский
Процитировано
3
International Journal of Clinical and Health Psychology, Год журнала: 2025, Номер 25(2), С. 100565 - 100565
Опубликована: Апрель 1, 2025
Low sleep quality induces inflammation. Because anti-thyroid peroxidase antibody (TPO-Ab) is an autoantibody that inflammation in the thyroid, insufficient may stimulate production of TPO-Ab. However, thyroid function also associated with sleep. Therefore, to evaluate association between TPO-Ab positivity and sleep, target population should be limited euthyroid individuals whose free triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH) are within normal ranges. This cross-sectional study recruited 1324 who participated annual health checkups. Insufficient was assessed by using a questionnaire. Individuals T3, T4, TSH levels ranges were defined as euthyroid. Among population, 406 had 242 TPO-Ab-positive. higher likelihood positivity. Sex age adjusted odd ratios (95 % confidence intervals, p) positive for 1.47 (1.08, 2.01, p = 0.014). These associations remained unchanged even after further adjustment T4 TSH, status body mass index, smoking status, drinking mental distress, physical activity; 1.53 (1.11, 2.10, 0.009). Euthyroid at risk autoimmune thyroiditis. Although investigations necessary, disorder therapy might reduce incidence
Язык: Английский
Процитировано
0
Cell stem cell, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microglia (iMG) could enable brain-wide and pathology-responsive cargo, we utilized CRISPR gene editing engineer iMG express Aβ-degrading enzyme neprilysin under control plaque-responsive promoter, CD9. further increased engraftment enhances efficacy, a CSF1R-inhibitor resistance approach. Interestingly, both localized in Alzheimer's disease (AD) mice reduced multiple biochemical measures pathology. However, within plaque-dense subiculum, reductions plaque load, dystrophic neurites, astrogliosis preservation neuronal density were only achieved following widespread microglial engraftment. Lastly, examined chimeric models breast cancer metastases demyelination, demonstrating that adopt diverse transcriptional responses differing neuropathologies, which be harnessed therapeutics CNS.
Язык: Английский
Процитировано
0
Chemistry & Biodiversity, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
ABSTRACT This study was conducted to investigate the mechanism of potential and anti‐inflammatory properties nitrogen‐substituted oleanolic acid derivatives that can be used treat neuroinflammatory diseases. Nitrogen‐containing have been evaluated for their anti‐neuroinflammatory effects in vitro neuronal monocytic cell lines at nontoxic doses, production cytokines (TNF‐α, IL‐6 IL‐17), inflammatory enzyme induced nitric oxide synthase (iNOS) NF‐κB signalling under LPS‐stimulated conditions, expression genes associated with Alzheimer's disease assessed. In addition, molecular docking dynamics simulation assessments are silico. Key protein markers neurodegenerative diseases, especially neuroinflammation, TAU levels, microglial activation, as well ionised calcium‐binding adaptor protein‐1 (IBA1) were significantly reduced addition derivatives. LPS‐induced luciferase reporter activity iNOS inhibited, approaching levels uninduced controls. The mRNA proinflammatory critical such TNF‐α, NF‐κB, IL‐17, twofold sevenfold. Furthermore, MD analyses revealed interactions TNF‐α proteins. These findings underscore derivatives, particularly compound 16 , candidates further development therapeutic agents diseases chronic inflammation.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2025, Номер 385, С. 119412 - 119412
Опубликована: Май 15, 2025
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106863 - 106863
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0