Exploring the Prospects of Transcranial Electrical Stimulation (tES) as a Therapeutic Intervention for Post-Stroke Motor Recovery: A Narrative Review
Brain Sciences,
Год журнала:
2024,
Номер
14(4), С. 322 - 322
Опубликована: Март 27, 2024
Introduction:
Stroke
survivors
often
have
motor
impairments
and
related
functional
deficits.
Transcranial
Electrical
Stimulation
(tES)
is
a
rapidly
evolving
field
that
offers
wide
range
of
capabilities
for
modulating
brain
function,
it
safe
inexpensive.
It
has
the
potential
widespread
use
post-stroke
recovery.
Direct
Current
(tDCS),
Alternating
(tACS),
Random
Noise
(tRNS)
are
three
recognized
tES
techniques
gained
substantial
attention
in
recent
years
but
different
mechanisms
action.
tDCS
been
widely
used
stroke
rehabilitation,
while
applications
tACS
tRNS
very
limited.
The
protocols
could
vary
significantly,
outcomes
heterogeneous.
Purpose:
current
review
attempted
to
explore
underlying
commonly
employed
evaluate
their
prospective
advantages
challenges
recovery
after
stroke.
Conclusion:
depolarize
hyperpolarize
potentials
cortical
neurons,
target
specific
rhythms
entrain
neural
networks.
Despite
extensive
tDCS,
complexity
networks
calls
more
sophisticated
modifications
like
tRNS.
Язык: Английский
The application of Non-invasive Neuromodulation in Stuttering: Current Status and Future Directions
Journal of Fluency Disorders,
Год журнала:
2025,
Номер
83, С. 106100 - 106100
Опубликована: Янв. 27, 2025
Язык: Английский
Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation
Journal of NeuroEngineering and Rehabilitation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 27, 2025
Transcranial
alternating
current
stimulation
(tACS)
is
a
non-invasive
technique
that
modulates
neural
oscillations,
yet
its
specific
effects
on
cortical
excitability
are
not
well-understood.
This
study
investigated
the
of
tACS
neuroplasticity
in
primary
motor
cortex
(M1)
across
different
frequencies.
In
this
randomized,
sham-controlled,
crossover
study,
18
healthy
young
adults
received
β-tACS
γ-tACS,
and
sham
over
M1.
Neurophysiological
responses
were
assessed
using
evoked
potentials
(MEPs),
electroencephalograms
(EEG),
transcranial
(TEPs)
to
determine
frequency-specific
neuroplasticity.
γ-tACS
significantly
enhanced
excitability,
as
reflected
by
larger
MEP
amplitudes
compared
both
stimulation.
addition,
resulted
smaller
M1-P15
TEP
than
other
conditions.
contrast,
did
produce
significant
changes
either
MEPs
or
TEPs
These
findings
provide
evidence
induces
frequency-dependent
within
selective
modulation
with
suggests
potential
therapeutic
intervention
for
optimizing
function
rehabilitation.
was
registered
Chinese
Clinical
Trial
Registry
(ChiCTR2300074898,
date
registration:
2023/08/18).
Язык: Английский
Relationship between long-term shift work; night work; sleep deficiency and stroke: A systematic review and meta-analysis
Sleep Medicine,
Год журнала:
2024,
Номер
119, С. 499 - 504
Опубликована: Май 17, 2024
Язык: Английский
μ‐Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability
European Journal of Neuroscience,
Год журнала:
2025,
Номер
61(5)
Опубликована: Март 1, 2025
Transcranial
alternating
current
stimulation
(tACS)
has
been
proposed
to
modulate
neural
activity
through
two
primary
mechanisms:
entrainment
and
neuroplasticity.
The
study
aimed
probe
both
of
these
mechanisms
in
the
context
sensorimotor
μ-rhythm
using
transcranial
magnetic
(TMS)
electroencephalography
(EEG)
assess
corticospinal
excitability
(CSE)
during
(i.e.,
online)
immediately
following
stimulation,
as
well
neuroplastic
aftereffects
on
CSE
μ
EEG
power.
Thirteen
participants
received
three
sessions
stimulation.
Each
session
consisted
90
trials
μ-tACS
tailored
each
participant's
individual
frequency
(IMF),
with
trial
consisting
16
s
tACS
followed
by
8
rest
(for
a
total
24
min
12
per
session).
Motor-evoked
potentials
(MEPs)
were
acquired
at
start
end
(n
=
41),
additional
MEPs
across
different
phases
epochs
within
for
epoch):
early
online,
late
online
offline
echo.
Resting
was
recorded
start,
throughout
session.
data
then
pooled
participant
maximise
MEP
sample
size
participant.
We
present
preliminary
evidence
persisting
beyond
have
also
replicated
plastic
facilitation
observed
previous
studies,
thus
supporting
neuroplasticity
which
can
activity.
Язык: Английский
Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials
Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Март 12, 2025
Transcranial
alternating
current
stimulation
(tACS)
is
a
promising
non-invasive
neuromodulation
technique
with
the
potential
for
inducing
neuroplasticity
and
enhancing
cognitive
clinical
outcomes.
A
unique
feature
of
tACS,
compared
to
other
modalities,
that
it
modulates
brain
activity
by
entraining
neural
oscillations
an
externally
applied
current.
While
many
studies
have
focused
on
online
effects
during
stimulation,
growing
evidence
suggests
tACS
can
induce
sustained
after-effects,
which
emphasizes
long-term
neurophysiological
changes,
essential
therapeutic
applications.
In
first
part
this
review,
we
discuss
how
after-effects
could
be
mediated
four
non-mutually
exclusive
mechanisms.
First,
spike-timing-dependent
plasticity
(STDP),
where
timing
pre-
postsynaptic
spikes
strengthens
or
weakens
synaptic
connections.
Second,
spike-phase
coupling
oscillation
phase
as
mediators
plasticity.
Third,
homeostatic
plasticity,
emphasizing
importance
operate
within
dynamic
physiological
ranges.
Fourth,
state-dependent
highlights
state
in
modulatory
tACS.
second
applications
trials
targeting
neurological
psychiatric
disorders,
including
major
depressive
disorder,
schizophrenia,
Parkinson’s
disease,
Alzheimer’s
disease.
Evidence
repeated
sessions,
optimized
individual
oscillatory
frequencies
combined
behavioral
interventions,
may
result
lasting
enhance
However,
critical
challenges
remain,
need
personalized
dosing,
improved
modeling,
systematic
investigation
effects.
conclusion,
review
mechanisms
translational
bridging
basic
neuroscience
research
optimize
its
use
tool.
Язык: Английский
The Influence of Transcranial Alternating Current Stimulation on the Excitability of the Unstimulated Contralateral Primary Motor Cortex
Brain Sciences,
Год журнала:
2025,
Номер
15(5), С. 512 - 512
Опубликована: Май 17, 2025
Objectives:
Transcranial
alternating
current
stimulation
(tACS)
can
enhance
primary
motor
cortex
(M1)
excitability
and
improve
skill
when
delivered
unilaterally
to
the
dominant
hemisphere.
However,
impact
of
tACS
on
contralateral
M1
both
during
after
application
has
not
been
studied.
The
purpose
this
study
was
examine
effects
left
unstimulated
non-dominant
right
M1.
Methods:
This
implemented
a
double-blind,
randomized,
SHAM-controlled,
within-subjects,
crossover
experimental
design.
Eighteen
young
adults
completed
condition
SHAM
two
different
days
in
counterbalanced
order
with
week
washout
period
between
days.
magnetic
(TMS)
utilized
assess
while
TMS
administered
five
test
blocks
(termed
Pre,
D5,
D10,
D15,
Post)
relative
20
min
(70
Hz,
1
mA
strength).
Pre
Post
were
conducted
before
immediately
applied
M1,
whereas
performed
at
time
points
starting
5,
10,
15
marks
period.
dependent
variable
mV
evoked
potential
(MEP)
amplitude.
MEP
data
analyzed
2
(tACS,
SHAM)
×
5
(Pre,
within-subjects
ANOVA.
Results:
main
effect
for
(p
=
0.704)
interaction
0.349)
non-statistically
significant.
There
significant
0.003);
however,
post
hoc
analysis
indicated
that
none
pairwise
comparisons
statistically
Conclusions:
Overall,
findings
indicate
does
significantly
modulate
or
stimulation,
least
utilizing
present
parameters.
Язык: Английский
Motor Learning in a Complex Motor Task Is Unaffected by Three Consecutive Days of Transcranial Alternating Current Stimulation
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 744 - 744
Опубликована: Июль 23, 2024
Transcranial
alternating
current
stimulation
(tACS)
delivered
to
the
primary
motor
cortex
(M1)
can
increase
cortical
excitability,
entrain
neuronal
firing
patterns,
and
skill
acquisition
in
simple
tasks.
The
aim
of
this
study
was
assess
impact
tACS
applied
M1
over
three
consecutive
days
practice
on
learning
a
challenging
overhand
throwing
task
young
adults.
secondary
examine
influence
excitability.
This
implemented
double-blind,
randomized,
SHAM-controlled,
between-subjects
experimental
design.
A
total
24
healthy
adults
were
divided
into
SHAM
groups
performed
identical
sessions
that
comprised
blocks
trials
right
dominant
arm
concurrent
with
application
left
M1.
Performance
quantified
as
endpoint
error.
Motor
evoked
potentials
(MEPs)
assessed
first
dorsal
interosseus
(FDI)
muscle
transcranial
magnetic
(TMS)
quantify
changes
Endpoint
error
significantly
decreased
post-tests
compared
pre-tests
when
averaged
(
Язык: Английский
A bibliometric analysis of transcranial alternating current stimulation
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 2, 2024
Transcranial
alternating
current
stimulation
(tACS)
can
apply
currents
of
varying
intensity
to
the
scalp,
modulating
cortical
excitability
and
brain
activity.
tACS
is
a
relatively
new
neuromodulation
intervention
that
now
widely
used
in
clinical
practice.
Many
papers
related
have
been
published
various
journals.
However,
there
are
no
articles
objectively
directly
introduce
development
trend
research
hotspots
tACS.
Therefore,
aim
this
study
use
CiteSpace
visually
analyze
recent
tACS-related
publications,
systematically
detail
summarize
trends
field,
provide
valuable
information
for
future
research.
Язык: Английский