Auricular neuromodulation may act through interoception modulation
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149736 - 149736
Опубликована: Май 1, 2025
Язык: Английский
Transcutaneous auricular vagus nerve stimulation to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial
Trials,
Год журнала:
2024,
Номер
25(1)
Опубликована: Июнь 19, 2024
Abstract
Background
Borderline
personality
disorder
(BPD)
is
considered
a
of
emotion
regulation
resulting
from
the
expression
biologically
determined
emotional
vulnerability
(that
is,
heightened
sensitivity
to
emotion,
increased
intensity/reactivity,
and
slow
return
baseline)
combined
with
exposure
invalidating
environments.
Vagal
tone
has
been
associated
activity
in
cortical
regions
involved
lower
resting
state
vagal
observed
BPD
patients
relative
healthy
controls.
Non-invasive
transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
shown
reduce
temper
outbursts
adults
Prader-Willi
Syndrome,
enhance
recognition
emotions
students,
improve
depressive
anxiety
symptoms.
Furthermore,
single
session
taVNS
acutely
alter
facial
expressions
negative
valence
adolescents
MDD
increase
However,
effect
on
individuals
diagnosed
not
investigated.
Our
aims
are
determine
if
effective
reducing
patients.
Methods
Forty-two
will
be
randomized
or
sham-taVNS
while
going
through
an
affect
induction
procedure.
It
consist
presentation
one
neutral
three
affect-evoking
4-min-long
videos
sequence,
each
which
followed
by
4-min
post-induction
period
during
participants
rate
quality
intensity
their
current
self-reported
(post-induction
ratings)
perceived
effectiveness
managing
video
presentation.
The
rating
repeated
after
every
(recovery
ratings).
Mixed
models
as
random
used
investigate
ratings
at
stage
study,
taking
into
account
measures
same
baseline,
pre-induction,
post-induction,
recovery.
Discussion
study
potential
yield
new
insights
role
dysregulation
offer
preliminary
data
possible
non-invasive
brain
treat
core
symptom
BPD.
Trial
registration
ClinicalTrials.gov
NCT05892900.
Retrospectively
registered
Jun
07,
2023.
Язык: Английский
Clinical application of respiratory-gated auricular vagal afferent nerve stimulation
Neuroscience,
Год журнала:
2024,
Номер
565, С. 117 - 123
Опубликована: Ноя. 28, 2024
Язык: Английский
Investigating the effects of transcutaneous Vagus Nerve Stimulation on motor cortex excitability and inhibition through paired-pulse Transcranial Magnetic Stimulation
Boscarol Sara,
Turchi Letizia,
Oldrati Viola
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
Abstract
Transcutaneous
Vagus
Nerve
stimulation
(tVNS)
has
been
proposed
as
a
prospective
treatment
for
clinical
conditions
with
altered
GABAergic
transmission.
While
possible
effects
of
tVNS
on
behavioral
performance
in
inhibitory
control
tasks
have
previously
reported,
neurophysiological
evidence
showing
its
GABA-mediated
inhibition
the
motor
cortex
is
limited.
Concurrently,
influence
participant’s
gender
and
state
remains
unexplored.
Here,
we
applied,
single-
paired-pulse
TMS
to
right
or
left
primary
two
different
groups
participants.
We
measured
corticospinal
excitability
(CSE),
short
long
intracortical
(SICI
LICI),
cortical
silent
period
(cSP)
facilitation
(ICF)
indexes.
The
measures
were
taken,
separated
sessions
within-subject
design,
at
baseline
prior
after
delivering
active
sham
Cymba
conchae
ear.
To
exploit
dependent
assess
role
learning,
was
during
execution
computerized
visuomotor
task.
In
group,
observed
better
than
tVNS,
regardless
gender.
Interestingly,
both
groups,
found
specific
increase
SICI,
which
mediated
by
GABAa
activity,
compared
sham-tVNS
evaluations,
specifically
limited
female
No
CSE,
ICF
GABAb-mediated
indexes
observed.
results
show
learning
GABAa-mediated
inhibition,
providing
supportive
application
an
alternative
coadjuvant
disorders
featured
mechanisms.
Язык: Английский