Transcranial direct current stimulation over the motor and premotor cortex with mirror therapy improves motor control, muscle function, and brain activity in chronic stroke: a double-blind randomized sham-controlled trial
Journal of NeuroEngineering and Rehabilitation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Апрель 26, 2025
Transcranial
direct
current
stimulation
(tDCS)
is
a
popular
approach
to
augment
the
effects
of
neurorehabilitation.
Most
studies
stimulated
ipsilesional
primary
motor
cortex
(iM1);
nonetheless,
success
iM1
was
variable,
suggesting
that
it
may
not
be
optimal
for
improving
recovery.
Ipsilesional
premotor
(iPMC)
an
alternative
candidate
based
on
its
likelihood
survival
post-stroke
and
contribution
functions.
This
study
aimed
determine
tDCS
iPMC
with
mirror
therapy
(MT)
control,
muscle
function,
brain
activity
in
chronic
stroke.
Thirty-six
participants
were
randomly
distributed
into
(1)
iPMC-tDCS
MT
(PMC)
(2),
iM1-tDCS
(M1),
(3)
sham
(sham).
Motor
control
assessed
using
kinematics.
Muscle
function
modified
Ashworth
Medical
Research
Council
Scales.
The
M1
PMC
recorded
electroencephalography
(EEG),
event-related
desynchronization
laterality
index
(LI)
examined.
Significant
within-group
differences
identified
kinematic
outcomes.
After
interventions,
group
showed
reduced
paretic
upper
limb
spasticity
improved
greater
movement
smoothness
peak
velocity.
trunk
compensation
fewer
displacement
flexion.
However,
relied
more
compensation,
demonstrating
increased
velocity
smoothness.
between-group
also
found
displacement.
Post-hoc
analysis
revealed
than
group.
within-and
EEG
contralesional
(cPMC)
from
pre-to-post
intervention
In
contrast,
decreased,
LI
declined
pre-
post-intervention
activity,
having
activation
Differential
treatment
benefits
between
iPMC-
MT.
uniquely
while
mitigated
during
reaching.
These
findings
suggest
both
could
stroke
neurorehabilitation
considered
clinical
applications.
ClinicalTrials.gov
Identifier:
NCT04655209.
Registered
15th
November
2020.
https://clinicaltrials.gov/study/NCT04655209
.
Язык: Английский
Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 23, 2025
Abstract
Neural
stem
cell
therapies
hold
great
promise
for
improving
stroke
recovery,
but
the
hostile
microenvironment
can
hinder
initial
graft
survival.
It
has
long
been
well
documented
that
evolves
over
time,
making
it
crucial
to
identify
optimal
transplantation
window
maximize
therapeutic
efficacy.
However,
remains
uncertain
whether
acute
or
delayed
local
transplantations
better
supports
viability
after
stroke.
Here,
is
shown
intracerebral
of
neural
progenitor
cells
(NPCs)
derived
from
human
induced
pluripotent
(iPSCs)
at
7
days
post
significantly
enhances
proliferation
and
survival,
promotes
axonal
sprouting,
compared
1
day
stroke,
in
a
mouse
model
large
cortical
Using
vivo
bioluminescence
imaging
6‐week
period
post‐transplantation,
more
than
fivefold
increase
observed
signal
mice
received
NPC
therapy,
those
underwent
transplantation.
The
increased
number
grafts
receiving
driven
by
rates
early
transplantation,
which
subsequently
declines
similarly
low
levels
both
groups.
Notably,
found
majority
transplanted
NPCs
differentiate
into
neurons
6
weeks,
with
no
significant
differences
neuron‐to‐glia
ratio
between
These
findings
suggest
improves
survival
proliferation,
could
help
maximizing
effectiveness
NPC‐based
Язык: Английский
fMRI in Cerebrovascular Disorders
Neuromethods,
Год журнала:
2025,
Номер
unknown, С. 711 - 729
Опубликована: Янв. 1, 2025
Noninvasive brain stimulation to improve motor outcomes after stroke
Current Opinion in Neurology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 2, 2024
Purpose
of
review
This
highlights
recent
developments
in
noninvasive
brain
stimulation
(NIBS)
techniques
and
applications
for
improving
motor
outcomes
after
stroke.
Two
promising
areas
development
relate
to
deep
neuromodulation
the
use
single-pulse
transcranial
magnetic
(TMS)
within
a
prediction
tool
predicting
upper
limb
outcome
individual
patients.
Recent
findings
Systematic
reviews
highlight
inconsistent
effect
sizes
interventional
NIBS
stroke,
as
well
limited
evidence
supporting
interhemispheric
competition
model.
To
improve
therapeutic
efficacy
NIBS,
studies
have
leveraged
metaplasticity
priming
approaches.
Transcranial
temporal
interference
(tTIS)
low-intensity
focused
ultrasound
(LIFUS)
are
emerging
with
potential
modulating
deeper
structures,
which
may
hold
promise
stroke
neurorehabilitation.
Additionally,
evoked
(MEP)
status
obtained
TMS
is
prognostic
biomarker
that
could
be
used
tailor
Summary
Trials
improved
by
applying
more
targeted
manner.
achieved
taking
advantage
can
using
biomarkers
structural
functional
reserve
stratify
patients,
recruiting
patients
homogeneous
time
windows.
Язык: Английский