Gut Microbiome—Brain Crosstalk in the Early Life of Chicken Reveals the Circadian Regulation of Key Metabolic and Immune Signaling Processes DOI Creative Commons
Mridula Gupta,

Mustafa Cilkiz,

Mohamed M. Ibrahim

и другие.

Microorganisms, Год журнала: 2025, Номер 13(4), С. 789 - 789

Опубликована: Март 30, 2025

Circadian rhythms are innate biological systems that control everyday behavior and physiology. Furthermore, bilateral interaction between the host’s circadian rhythm gut microbes influences a variety of health ramifications, including metabolic diseases, obesity, mental GALT physiology microbiome population. Therefore, we studying correlation differential gene expression in chicken brain microbiota abundance during rhythms. To understand this, raised freshly hatched chicks under two photoperiod treatments: normal (NP = 12/12 LD) extended (EP 23/1 LD). The were randomly assigned to one treatments. After 21 days entrainment, euthanized at nine time points spaced six hours apart over 48 h characterize transcriptomes. Each sample’s RNA was extracted, 36 mRNA libraries generated sequenced using Illumina technology, followed by data processing, count generation, analysis. We an average 17.5 million reads per library for 237.9 M reads. When aligned Galgal6 reference genome, 11,867 genes had detectable levels, with common dispersion value 0.105. identify follow 24 rhythms, counts performed DiscoRhythm. discovered 577 Cosinor 417 JTK cycle algorithm exhibit substantial used weighted co-expression network analysis (WGCNA) analyze differentially expressed abundance. most enriched pathways included aldosterone-regulated sodium reabsorption, endocrine other factor-regulated calcium GABAergic synapse, oxidative phosphorylation, serotonergic dopaminergic synapse entrainment. This study builds on our previous study, adds new findings about specific interactions co-regulation transcriptome microbiota. host highlights potential benefits microbiome-modulation approaches improve performance poultry.

Язык: Английский

Circadian clocks of the kidney: function, mechanism, and regulation DOI
Hannah M. Costello, Jermaine G. Johnston, Alexandria Juffre

и другие.

Physiological Reviews, Год журнала: 2022, Номер 102(4), С. 1669 - 1701

Опубликована: Май 16, 2022

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral clocks within cells kidney contribute to regulation a variety renal processes. In this review, we summarize what currently known regarding function, mechanism, and clocks. Additionally, effect extrarenal physiological processes, such as endocrine neuronal signals, on function also reviewed. Circadian rhythms are an integral part physiology, underscoring importance considering time day key biological variable. field physiology tremendous relevance, but with limited mechanistic information area need extensive investigation.

Язык: Английский

Процитировано

46
Inputs and Outputs of the Mammalian Circadian Clock DOI Creative Commons

Ashley N. Starnes,

Jeff R. Jones

Biology, Год журнала: 2023, Номер 12(4), С. 508 - 508

Опубликована: Март 28, 2023

Circadian rhythms in mammals are coordinated by the central circadian pacemaker, suprachiasmatic nucleus (SCN). Light and other environmental inputs change timing of SCN neural network oscillator, which, turn, sends output signals that entrain daily behavioral physiological rhythms. While much is known about molecular, neuronal, properties itself, circuits linking outside world to rhythmic outputs understudied. In this article, we review our current understanding synaptic non-synaptic onto from SCN. We propose a more complete description connectivity needed better explain how nearly all behaviors processes generated determine how, mechanistically, these disrupted disease or lifestyle.

Язык: Английский

Процитировано

39
Brain circadian clocks timing the 24h rhythms of behavior DOI Creative Commons
Jorge Mendoza

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

2
Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior DOI Creative Commons
Alessandra Porcu, Anna Nilsson,

Sathwik Booreddy

и другие.

Science Advances, Год журнала: 2022, Номер 8(35)

Опубликована: Сен. 2, 2022

Seasonal changes in day length (photoperiod) affect numerous physiological functions. The suprachiasmatic nucleus (SCN)–paraventricular (PVN) axis plays a key role processing photoperiod-related information. variations SCN and PVN neurotransmitter expression have been observed humans animal models. However, the molecular mechanisms by which SCN-PVN network responds to altered photoperiod is unknown. Here, we show mice that neuromedin S (NMS) vasoactive intestinal polypeptide (VIP) neurons display photoperiod-induced plasticity. In vivo recording of calcium dynamics revealed NMS alter activity response winter-like photoperiod. Chronic manipulation sufficient induce switching affects locomotor activity. Our findings reveal previously unidentified adaptations seasonality for adjusting hypothalamic function via coordinated multisynaptic affecting behavior.

Язык: Английский

Процитировано

36
Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases DOI Creative Commons
Xin Yi Yeo, Grace Cunliffe, Roger Ho

и другие.

Biomedicines, Год журнала: 2022, Номер 10(2), С. 343 - 343

Опубликована: Фев. 1, 2022

Despite recent leaps in modern medicine, progress the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents entry therapeutics into brain, and complexity processes, limits specificity potential therapeutics. Moreover, a lack etiological understanding irreversible nature conditions have resulted low tolerability high failure rates towards existing small molecule-based treatments. Neuropeptides, which are proteinaceous molecules produced by body, either nervous system or peripheral organs, modulate function. Although peptide-based originated from metabolic 1920s, adoption development peptide drugs for relatively recent. In this review, we examine natural roles neuropeptides modulation function disorders. Furthermore, highlight these filling gaps current

Язык: Английский

Процитировано

34
Disturbances of Hormonal Circadian Rhythms by Light Pollution DOI Open Access
Michal Zeman, Monika Okuliarová, Valentina Sophia Rumanova

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7255 - 7255

Опубликована: Апрель 14, 2023

The circadian rhythms evolved to anticipate and cope with cyclic changes in environmental conditions. This adaptive function is currently compromised by increasing levels of artificial light at night (ALAN), which can represent a risk for the development diseases civilisation. causal links are not completely understood, this featured review focuses on chronodisruption neuroendocrine control physiology behaviour dim ALAN. published data indicate that low ALAN (2–5 lux) attenuate molecular mechanisms generating central oscillator, eliminate rhythmic dominant hormonal signals, such as melatonin, testosterone vasopressin, interfere rhythm glucocorticoid corticosterone rodents. These associated disturbed daily pattern metabolic behavioural activity food water intake. require identification pathways mediating possible negative consequences health design effective mitigation strategies or minimise effects pollution.

Язык: Английский

Процитировано

19
Disruption of circadian rhythm as a potential pathogenesis of nocturia DOI
Qixiang Song, Sylvia O. Suadicani, Hiromitsu Negoro

и другие.

Nature Reviews Urology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Язык: Английский

Процитировано

7
Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep DOI Creative Commons
Matthias Schlichting, Shlesha Richhariya, Nicholas Herndon

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(34)

Опубликована: Авг. 15, 2022

The metronome-like circadian regulation of sleep timing must still adapt to an uncertain environment. Recent studies in Drosophila indicate that neuromodulation not only plays a key role clock neuron synchronization but also affects interactions between the network and brain centers. We show here targets neuromodulators, G Protein Coupled Receptors (GPCRs), are highly enriched fly network. Single-cell sequencing indicates they differentially expressed contribute identity. generated comprehensive guide library mutagenize individual GPCRs specific neurons verified strategy by introducing targeted approach. Combined with behavioral screen, mutagenesis revealed dopamine identifying two receptors subpopulation gate sleep.

Язык: Английский

Процитировано

29
Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis DOI Creative Commons
Andy Pérez‐Villa, Gabriela Echeverría‐Garcés,

María José Ramos-Medina

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 30, 2023

Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field chronobiology has increased our understanding how rhythm disturbances contribute to cancer pathogenesis, circadian timing influences the efficacy treatments. As clock steadily gains recognition as an emerging factor in tumorigenesis, a thorough comprehensive multi-omics analysis CR genes/proteins never been performed. To shed light on this, we performed, for first time, integrated data encompassing genomic/transcriptomic alterations across 32 types (n = 10,918 tumors) taken from PanCancer Atlas, unfavorable prognostic protein analysis, protein-protein interactomics, shortest distance score pathways hallmark phenotypes. This mining strategy allowed us unravel 31 essential CR-related proteins involved signaling crossroad between In context drugging clock, identified pharmacogenomic clinical annotations drugs currently late phase trials could be considered potential therapeutic strategies. These findings highlight diverse roles realm research therapy.

Язык: Английский

Процитировано

15
SIK3–HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice DOI Creative Commons
Fuyuki Asano, Staci Jakyong Kim, Tomoyuki Fujiyama

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(11)

Опубликована: Март 6, 2023

Mammals exhibit circadian cycles of sleep and wakefulness under the control suprachiasmatic nucleus (SCN), such as strong arousal phase-locked to beginning dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing delayed peak lengthened behavioral cycle both 12-h light:12-h condition (LD) constant (DD) without changing daily amounts. In contrast, induction a gain-of-function mutant allele Sik3 GABAergic exhibited advanced activity onset shorter period. Loss SIK3 arginine vasopressin (AVP)-producing cycle, but was similar Heterozygous histone deacetylase (HDAC) 4, substrate, shortened whereas mice with HDAC4 S245A, which is resistant phosphorylation by SIK3, phase. Phase-delayed core clock gene expressions were detected liver lacking neurons. These results suggest SIK3-HDAC4 pathway regulates period length timing through NMS-positive SCN.

Язык: Английский

Процитировано

14