Frontiers in Physiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 22, 2024
Light-sensitive
neurons
are
located
in
the
ventral
and
central
core
of
suprachiasmatic
nucleus
(SCN),
whereas
stably
oscillating
clock
found
mainly
dorsal
shell.
Signals
between
SCN
shell
believed
to
play
an
important
role
light
entrainment.
Core
express
vasoactive
intestinal
polypeptide
(VIP),
gastrin-releasing
peptide
(GRP),
Neuroglobin
(Ngb),
vasopressin
(AVP),
prokineticin
2,
VIP
type
2
(VPAC2)
receptor.
In
rodents,
has
a
phase-shifting
capacity
at
night,
which
induces
rapid
transient
expression
EGR1
FOS
SCN.
Methods:
The
present
study
used
immunohistochemical
staining
FOS,
EGR1,
phenotypical
markers
(VIP,
AVP,
Ngb)
identify
subtypes/populations
light-responsive
early
night.
Results:
Double
immunohistochemistry
cell
counting
were
evaluate
number
expressing
either
or
was
higher
than
total
co-storing
FOS.
Of
cells,
42%
expressed
only
43%
15%
both
Light-responsive
represented
31%
all
neurons,
represents
largest
group
(18%).
1%
neurons.
81%
Ngb
mouse
light-responsive,
these
after
stimulation
44%,
24%
Although
most
SCN,
29%
AVP
8%
10%
11%
co-expressed
stimulation.
Discussion:
Our
analysis
revealed
cell-specific
differences
responsiveness
different
peptidergic
Ngb-expressing
compartments
indicating
that
activates
diverse
neuronal
networks
some
participate
photoentrainment.
Physiological Reviews,
Год журнала:
2022,
Номер
102(4), С. 1669 - 1701
Опубликована: Май 16, 2022
An
intrinsic
cellular
circadian
clock
is
located
in
nearly
every
cell
of
the
body.
The
peripheral
clocks
within
cells
kidney
contribute
to
regulation
a
variety
renal
processes.
In
this
review,
we
summarize
what
currently
known
regarding
function,
mechanism,
and
clocks.
Additionally,
effect
extrarenal
physiological
processes,
such
as
endocrine
neuronal
signals,
on
function
also
reviewed.
Circadian
rhythms
are
an
integral
part
physiology,
underscoring
importance
considering
time
day
key
biological
variable.
field
physiology
tremendous
relevance,
but
with
limited
mechanistic
information
area
need
extensive
investigation.
Biology,
Год журнала:
2023,
Номер
12(4), С. 508 - 508
Опубликована: Март 28, 2023
Circadian
rhythms
in
mammals
are
coordinated
by
the
central
circadian
pacemaker,
suprachiasmatic
nucleus
(SCN).
Light
and
other
environmental
inputs
change
timing
of
SCN
neural
network
oscillator,
which,
turn,
sends
output
signals
that
entrain
daily
behavioral
physiological
rhythms.
While
much
is
known
about
molecular,
neuronal,
properties
itself,
circuits
linking
outside
world
to
rhythmic
outputs
understudied.
In
this
article,
we
review
our
current
understanding
synaptic
non-synaptic
onto
from
SCN.
We
propose
a
more
complete
description
connectivity
needed
better
explain
how
nearly
all
behaviors
processes
generated
determine
how,
mechanistically,
these
disrupted
disease
or
lifestyle.
Biomedicines,
Год журнала:
2022,
Номер
10(2), С. 343 - 343
Опубликована: Фев. 1, 2022
Despite
recent
leaps
in
modern
medicine,
progress
the
treatment
of
neurological
diseases
remains
slow.
The
near
impermeable
blood-brain
barrier
(BBB)
that
prevents
entry
therapeutics
into
brain,
and
complexity
processes,
limits
specificity
potential
therapeutics.
Moreover,
a
lack
etiological
understanding
irreversible
nature
conditions
have
resulted
low
tolerability
high
failure
rates
towards
existing
small
molecule-based
treatments.
Neuropeptides,
which
are
proteinaceous
molecules
produced
by
body,
either
nervous
system
or
peripheral
organs,
modulate
function.
Although
peptide-based
originated
from
metabolic
1920s,
adoption
development
peptide
drugs
for
relatively
recent.
In
this
review,
we
examine
natural
roles
neuropeptides
modulation
function
disorders.
Furthermore,
highlight
these
filling
gaps
current
Seasonal
changes
in
day
length
(photoperiod)
affect
numerous
physiological
functions.
The
suprachiasmatic
nucleus
(SCN)–paraventricular
(PVN)
axis
plays
a
key
role
processing
photoperiod-related
information.
variations
SCN
and
PVN
neurotransmitter
expression
have
been
observed
humans
animal
models.
However,
the
molecular
mechanisms
by
which
SCN-PVN
network
responds
to
altered
photoperiod
is
unknown.
Here,
we
show
mice
that
neuromedin
S
(NMS)
vasoactive
intestinal
polypeptide
(VIP)
neurons
display
photoperiod-induced
plasticity.
In
vivo
recording
of
calcium
dynamics
revealed
NMS
alter
activity
response
winter-like
photoperiod.
Chronic
manipulation
sufficient
induce
switching
affects
locomotor
activity.
Our
findings
reveal
previously
unidentified
adaptations
seasonality
for
adjusting
hypothalamic
function
via
coordinated
multisynaptic
affecting
behavior.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7255 - 7255
Опубликована: Апрель 14, 2023
The
circadian
rhythms
evolved
to
anticipate
and
cope
with
cyclic
changes
in
environmental
conditions.
This
adaptive
function
is
currently
compromised
by
increasing
levels
of
artificial
light
at
night
(ALAN),
which
can
represent
a
risk
for
the
development
diseases
civilisation.
causal
links
are
not
completely
understood,
this
featured
review
focuses
on
chronodisruption
neuroendocrine
control
physiology
behaviour
dim
ALAN.
published
data
indicate
that
low
ALAN
(2–5
lux)
attenuate
molecular
mechanisms
generating
central
oscillator,
eliminate
rhythmic
dominant
hormonal
signals,
such
as
melatonin,
testosterone
vasopressin,
interfere
rhythm
glucocorticoid
corticosterone
rodents.
These
associated
disturbed
daily
pattern
metabolic
behavioural
activity
food
water
intake.
require
identification
pathways
mediating
possible
negative
consequences
health
design
effective
mitigation
strategies
or
minimise
effects
pollution.
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(34)
Опубликована: Авг. 15, 2022
The
metronome-like
circadian
regulation
of
sleep
timing
must
still
adapt
to
an
uncertain
environment.
Recent
studies
in
Drosophila
indicate
that
neuromodulation
not
only
plays
a
key
role
clock
neuron
synchronization
but
also
affects
interactions
between
the
network
and
brain
centers.
We
show
here
targets
neuromodulators,
G
Protein
Coupled
Receptors
(GPCRs),
are
highly
enriched
fly
network.
Single-cell
sequencing
indicates
they
differentially
expressed
contribute
identity.
generated
comprehensive
guide
library
mutagenize
individual
GPCRs
specific
neurons
verified
strategy
by
introducing
targeted
approach.
Combined
with
behavioral
screen,
mutagenesis
revealed
dopamine
identifying
two
receptors
subpopulation
gate
sleep.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 31, 2023
The
circadian
system
in
mammals
ensures
adaptation
to
the
light-dark
cycle
on
Earth
and
imposes
24-h
rhythmicity
metabolic,
physiological
behavioral
processes.
central
pacemaker
is
located
brain
entrained
by
environmental
signals
called
Zeitgebers.
From
here,
neural,
humoral
systemic
drive
rhythms
peripheral
clocks
nearly
every
mammalian
tissue.
During
pregnancy,
disruption
of
complex
interplay
between
mother’s
rhythmic
fetal
developing
can
lead
long-term
health
consequences
offspring.
When
an
infant
born
very
preterm,
it
loses
temporal
received
from
mother
prematurely
becomes
totally
dependent
24/7
care
Neonatal
Intensive
Care
Unit
(NICU),
where
day/night
usually
blurred.
In
this
literature
review,
we
provide
overview
neonatal
development
system,
short-term
process
as
occurs
NICU
environment.
Moreover,
a
theoretical
molecular
framework
how
could
later-life
disease.
Finally,
discuss
studies
that
aim
improve
outcomes
after
preterm
birth
studying
effects
enhancing
light
noise
exposure.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Авг. 30, 2023
Circadian
rhythms
(CRs)
are
fundamental
biological
processes
that
significantly
impact
human
well-being.
Disruption
of
these
can
trigger
insufficient
neurocognitive
development,
insomnia,
mental
disorders,
cardiovascular
diseases,
metabolic
dysfunctions,
and
cancer.
The
field
chronobiology
has
increased
our
understanding
how
rhythm
disturbances
contribute
to
cancer
pathogenesis,
circadian
timing
influences
the
efficacy
treatments.
As
clock
steadily
gains
recognition
as
an
emerging
factor
in
tumorigenesis,
a
thorough
comprehensive
multi-omics
analysis
CR
genes/proteins
never
been
performed.
To
shed
light
on
this,
we
performed,
for
first
time,
integrated
data
encompassing
genomic/transcriptomic
alterations
across
32
types
(n
=
10,918
tumors)
taken
from
PanCancer
Atlas,
unfavorable
prognostic
protein
analysis,
protein-protein
interactomics,
shortest
distance
score
pathways
hallmark
phenotypes.
This
mining
strategy
allowed
us
unravel
31
essential
CR-related
proteins
involved
signaling
crossroad
between
In
context
drugging
clock,
identified
pharmacogenomic
clinical
annotations
drugs
currently
late
phase
trials
could
be
considered
potential
therapeutic
strategies.
These
findings
highlight
diverse
roles
realm
research
therapy.