Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Background
Recent
studies
have
explored
optical
coherence
tomography
(OCT)
and
OCT-angiography
(OCT-A)
as
biomarkers
for
Alzheimer's
disease
(AD).
However,
correlations
between
OCT/OCT-A
neurodegeneration
metrics
remain
underexplored.
Objective
We
performed
a
systematic
review
of
structural
brain
imaging
using
MRI
across
various
neurodegenerative
disorders.
Methods
searched
Medline,
Embase,
other
databases
from
January
to
June
2023
keywords
regarding
conditions
OCT/OCT-A.
Out
2962
citations.
93
articles
were
reviewed,
28
met
our
inclusion
criteria.
Results
Layer-or-region-specific
retinal
the
most
promising
non-vascular
neurodegeneration,
while
vascular
parameters
had
unique
capacity
reflect
lesions.
Both
types
correlated
with
global
atrophy.
Microstructural
alterations
best
layer-specific
thinning
retina.
Conclusions
A
better
understanding
associations
lesions
could
eventually
lead
clinical
application
early
diagnosis
conditions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15834 - 15834
Опубликована: Окт. 31, 2023
Alzheimer’s
disease
(AD)
represents
a
major
diagnostic
challenge,
as
early
detection
is
crucial
for
effective
intervention.
This
review
examines
the
challenges
facing
current
AD
evaluations
and
explores
emerging
field
of
retinal
alterations
indicators.
Recognizing
potential
retina
noninvasive
window
to
brain,
we
emphasize
importance
identifying
biomarkers
in
stages
AD.
However,
examination
not
without
its
challenges,
similarities
shared
with
other
diseases
introduce
complexity
search
AD-specific
markers.
In
this
review,
address
relevance
using
diagnosis
complex
associated
biomarkers.
We
provide
comprehensive
overview
landscape
highlight
avenues
progress
by
examination.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Autosomal
dominant
Alzheimer’s
disease
(ADAD)
is
a
rare
form
of
(AD)
in
which
the
biology
can
be
explored
during
presymptomatic
phase
illness.
The
retina
an
outgrowth
central
nervous
system
and
therefore
provides
opportunity
for
direct
observation
neural
tissue
its
vasculature
life.
Retinal
thinning
measured
vivo
has
been
previously
described
persons
carrying
ADAD
mutations
through
fundoscopy
but
pathologic
correlates
have
not
reported.
We
describe
retinal
lesions
detected
using
patient
homozygous
A431E
mutation
PSEN1
pathological
correlates.
seen
with
life
corresponded
to
intraretinal
prelaminar
optic
nerve
head
amyloid
β
42
-protein
that
were
surrounded
by
perivascular
anti-11A50-B10-Aβ
40
gliosis.
then
performed
cross-sectional,
observational
study
forty-one
Latinos
three
cohorts
consisting
(1)
causing
mutations,
(2)
at
50%
risk
for,
testing
negative
(3)
elderly
subjects
at-risk
ADAD.
Clinical
exam
demonstrated
novel,
yellow,
Cohort
1
absence
drusen.
Fifty-six
percent
had
>10
compared
0%
25%
Cohorts
2
3,
respectively
(
P
<
0.04).
There
some
controversy
as
detectability
Aβ
AD
our
findings
verify
presence
intraretinal,
prelaminar,
amyloidosis
detectable
subset
patients.
Frontiers in Aging Neuroscience,
Год журнала:
2022,
Номер
14
Опубликована: Ноя. 16, 2022
Retinal
structural
and
microvascular
changes
can
be
visualized
have
been
linked
with
cognitive
decline
brain
in
cerebral
age-related
disorders.
We
investigated
the
association
between
retinal
performance
volumes
elderly
adults.All
participants
underwent
magnetic
resonance
imaging
(MRI),
a
battery
of
neuropsychological
examinations.
Macula
thicknesses
(retinal
nerve
fiber
layer,
mRNFL,
ganglion
cell-inner
plexiform
GCIPL)
were
imaged
measured
swept-source
optical
coherence
tomography
(SS-OCT)
while
Optical
Coherence
Tomography
Angiography
(OCTA)
superficial
vascular
complex
(SVC)
deep
(DVC)
retina.Out
135
participants,
91
(67.41%)
females
none
had
dementia.
After
adjusting
for
risk
factors,
Shape
Trail
Test
(STT)-A
correlated
SVC
(P
<
0.001),
DVC
=
0.015)
mRNFL
0.013)
STT-B
0.020)
GCIPL
0.015).
thickness
Montreal
Cognitive
Assessment
(MoCA)
0.007)
Stroop
A
0.030).
factors
total
intracranial
volume,
hippocampal
volume
0.001).
Hippocampal
0.05)
most
measures.
B
0.001)
C
white
matter
measures
STT-A
gray
0.05).Our
findings
suggest
that
structure
microvasculature
useful
pointers
performance,
giving
choice
early
discovery
cognition
potential
treatment.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 3, 2024
Background
Digital
neuropsychological
tests
reliably
capture
real-time,
process-based
behavior
that
traditional
paper/pencil
cannot
detect,
enabling
earlier
detection
of
neurodegenerative
illness.
We
assessed
relations
between
informant-based
subtle
and
mild
functional
decline
features
extracted
from
the
digital
Trail
Making
Test-Part
B
(dTMT-B).
Methods
A
total
321
community-dwelling
participants
(56.0%
female)
were
with
Functional
Activities
Questionnaire
(FAQ)
dTMT-B.
Three
FAQ
groups
constructed:
=
0
(unimpaired);
1–4
(subtle
impairment);
5–8
(mild
impairment).
Results
Compared
to
FAQ-unimpaired
group,
other
required
longer
pauses
inside
target
circles
(
p
<
0.050)
produced
more
pen
strokes
complete
test
0.016).
FAQ-subtle
time
entire
0.002)
drew
individual
lines
connecting
successive
slower
0.001)
than
participants.
Lines
circle
targets
less
straight
among
FAQ-mild,
compared
0.044).
Using
stepwise
nominal
regression
(reference
group
FAQ-unimpaired),
classified
into
their
respective
0.015,
respectively).
Factor
analysis
using
six
dTMT-B
variables
(oblique
rotation)
yielded
a
two-factor
solution
related
impaired
motor/cognitive
operations
(48.96%
variance
explained)
faster
efficient
(28.88%
explained).
Conclusion
assessment
technology
elegantly
quantifies
occult,
nuanced
not
previously
appreciated,
operationally
defines
critical
underlying
neurocognitive
constructs
abilities,
yields
selected
scores
outperform
for
participant
classification.
When
brought
scale,
could
be
sensitive
tool
detect
subtle-to-mild
deficits
in
emergent
illnesses.
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Background
Recent
studies
have
explored
optical
coherence
tomography
(OCT)
and
OCT-angiography
(OCT-A)
as
biomarkers
for
Alzheimer's
disease
(AD).
However,
correlations
between
OCT/OCT-A
neurodegeneration
metrics
remain
underexplored.
Objective
We
performed
a
systematic
review
of
structural
brain
imaging
using
MRI
across
various
neurodegenerative
disorders.
Methods
searched
Medline,
Embase,
other
databases
from
January
to
June
2023
keywords
regarding
conditions
OCT/OCT-A.
Out
2962
citations.
93
articles
were
reviewed,
28
met
our
inclusion
criteria.
Results
Layer-or-region-specific
retinal
the
most
promising
non-vascular
neurodegeneration,
while
vascular
parameters
had
unique
capacity
reflect
lesions.
Both
types
correlated
with
global
atrophy.
Microstructural
alterations
best
layer-specific
thinning
retina.
Conclusions
A
better
understanding
associations
lesions
could
eventually
lead
clinical
application
early
diagnosis
conditions.
