Dystonia
is
the
third
most
common
movement
disorder.
It
causes
debilitating
twisting
postures
that
are
accompanied
by
repetitive
and
sometimes
intermittent
co-
or
over-contractions
of
agonist
antagonist
muscles.
Historically
diagnosed
as
a
basal
ganglia
disorder,
dystonia
increasingly
considered
network
disorder
involving
various
brain
regions
including
cerebellum.
In
certain
etiologies
dystonia,
aberrant
motor
activity
generated
in
cerebellum
abnormal
signals
then
propagate
through
“dystonia
circuit”
includes
thalamus,
ganglia,
cerebral
cortex.
Importantly,
it
has
been
reported
non-motor
defects
can
accompany
symptoms;
while
their
severity
not
always
correlated,
hypothesized
pathways
may
nevertheless
be
disrupted.
particular,
circadian
dysfunction
disordered
sleep
patient
complaints
dystonia.
Given
recent
evidence
suggesting
contains
oscillator,
displays
sleep-stage-specific
neuronal
activity,
sends
robust
long-range
projections
to
several
subcortical
involved
rhythm
regulation,
result
from
cerebellum-mediated
circuit.
Here,
we
review
linking
cerebellar
dysfunction,
involvement
sleep.
Together,
these
ideas
form
basis
for
development
improved
pharmacological
surgical
interventions
could
take
advantage
circuitry
restore
normal
function
well
(sleep)
behaviors
Nature Medicine,
Год журнала:
2024,
Номер
30(10), С. 3004 - 3014
Опубликована: Июль 12, 2024
Recent
advances
in
surgical
neuromodulation
have
enabled
chronic
and
continuous
intracranial
monitoring
during
everyday
life.
We
used
this
opportunity
to
identify
neural
predictors
of
clinical
state
12
individuals
with
treatment-resistant
obsessive-compulsive
disorder
(OCD)
receiving
deep
brain
stimulation
(DBS)
therapy
(
NCT05915741
).
developed
our
neurobehavioral
models
based
on
recordings
the
region
ventral
striatum
an
initial
cohort
five
patients
tested
validated
them
a
held-out
seven
additional
patients.
Before
DBS
activation,
most
symptomatic
state,
theta/alpha
(9
Hz)
power
evidenced
prominent
circadian
pattern
high
degree
predictability.
In
persistent
symptoms
(non-responders),
predictability
data
remained
consistently
high.
On
other
hand,
who
improved
symptomatically
(responders),
was
significantly
diminished.
This
feature
accurately
classified
status
even
limited
duration
recordings,
indicating
generalizability
that
could
facilitate
therapeutic
decision-making.
European Journal of Neuroscience,
Год журнала:
2025,
Номер
61(5)
Опубликована: Март 1, 2025
Non-motor
symptoms
can
severely
affect
the
quality
of
life
Parkinson's
disease-afflicted
patients,
with
most
common
ones
being
pain,
sleep
impairments,
and
neuropsychiatric
manifestations.
In
advanced
cases,
complex
fluctuations
motor
non-motor
occur
despite
optimal
medication.
Research
on
deep
brain
stimulation
subthalamic
nucleus
suggests
that
it
may
provide
benefits
for
treating
in
addition
to
improving
symptoms.
With
recent
advancements
technology,
simultaneous
recording
local
field
potentials
delivery
therapeutic
is
possible.
This
opens
new
possibilities
better
understanding
pathophysiology
disease
identifying
potential
electrophysiological
biomarkers
accurately
represent
these
Specifically,
this
review
aims
highlight
nucleus.
The
main
findings
indicate
activities
beta
frequency
band
are
associated
nociception
impairments
such
as
insomnia
rapid
eye
movement
behavior
disorders.
Additionally,
theta
alpha
bands
seem
reflect
neurocognitive
manifestations,
including
depression
impulse
control
A
could
improve
clinical
management
disease.
They
hold
promise
adjusting
parameters
open-loop
settings
might
eventually
be
applied
closed-loop
systems,
though
their
true
impact
remains
uncertain.
Dystonia
is
the
third
most
common
movement
disorder.
It
causes
debilitating
twisting
postures
that
are
accompanied
by
repetitive
and
sometimes
intermittent
co-
or
over-contractions
of
agonist
antagonist
muscles.
Historically
diagnosed
as
a
basal
ganglia
disorder,
dystonia
increasingly
considered
network
disorder
involving
various
brain
regions
including
cerebellum.
In
certain
etiologies
dystonia,
aberrant
motor
activity
generated
in
cerebellum
abnormal
signals
then
propagate
through
“dystonia
circuit”
includes
thalamus,
ganglia,
cerebral
cortex.
Importantly,
it
has
been
reported
non-motor
defects
can
accompany
symptoms;
while
their
severity
not
always
correlated,
hypothesized
pathways
may
nevertheless
be
disrupted.
particular,
circadian
dysfunction
disordered
sleep
patient
complaints
dystonia.
Given
recent
evidence
suggesting
contains
oscillator,
displays
sleep-stage-specific
neuronal
activity,
sends
robust
long-range
projections
to
several
subcortical
involved
rhythm
regulation,
result
from
cerebellum-mediated
circuit.
Here,
we
review
linking
cerebellar
dysfunction,
involvement
sleep.
Together,
these
ideas
form
basis
for
development
improved
pharmacological
surgical
interventions
could
take
advantage
circuitry
restore
normal
function
well
(sleep)
behaviors
