Journal of Visualized Experiments,
Год журнала:
2022,
Номер
190
Опубликована: Дек. 9, 2022
Many
reports
in
the
last
15
years
have
assessed
changes
auditory
brainstem
response
(ABR)
waveform
after
insults
such
as
noise
exposure.
Common
include
reductions
peak
1
amplitude
and
relative
latencies
of
later
peaks,
well
increased
central
gain,
which
is
reflected
by
a
increase
amplitudes
peaks
compared
to
1.
experimenters
identify
troughs
visually
assess
their
heights
latencies,
laborious
process
when
waveforms
are
collected
5
dB
increments
throughout
hearing
range
for
each
frequency
condition.
This
paper
describes
free
routines
that
may
be
executed
open-source
platform
R
with
RStudio
interface
semi-automate
measurements
waveforms.
The
troughs,
display
these
on
generated
inspection,
collate
annotate
results
into
spreadsheet
statistical
analysis,
generate
averaged
figures.
In
cases
automated
misidentifies
ABR
waveform,
there
an
additional
tool
assist
correction.
goal
reduce
time
effort
needed
analyze
so
more
researchers
will
analyses
future.
Brain and Behavior,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Introduction
Previous
studies
have
investigated
listening
effort
in
tinnitus
patients
compared
to
healthy
individuals.
These
reported
similar
pure
tone
hearing
thresholds
between
groups
but
did
not
investigate
possible
peripheral
auditory
dysfunction,
which
could
affect
the
central
system
and
increase
even
when
are
within
normal
range.
This
study
aimed
presence
of
by
controlling
for
function
(PAF).
Methods
included
16
chronic
23
matched
controls,
both
with
thresholds.
The
subjects
were
assessed
using
0.125–20
kHz
pure‐tone
audiometry,
a
visual
analogue
scale
(VAS),
Montreal
Cognitive
Assessment
(MoCA),
Tinnitus
Handicap
Inventory
(THI),
matrix
test,
brainstem
response
(ABR),
electroencephalography
(EEG).
EEG
alpha
band
activity
was
recorded
from
parietal
electrodes
(P3,
P4,
P
z
).
Results
power
during
encoding
phase
sentence
presentation
less
than
that
control
group.
We
found
higher
VAS
scores
participants.
find
significant
differences
test
scores,
ABR
amplitude,
or
absolute
latency
values
groups.
change
THI
show
correlation.
Conclusion
To
best
our
knowledge,
this
is
first
controls
while
PAF.
may
expend
more
listening‐related
despite
having
PAF
Frontiers in Neurology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 12, 2023
This
study
was
performed
to
assess
identifiable
abnormalities
in
tinnitus
patients
with
normal
hearing.The
medical
records
of
subjective
non-pulsatile
hearing
confirmed
by
conventional
pure-tone
audiometry
who
visited
our
clinic
between
March
2020
and
May
2022
were
reviewed.
The
loudness
discomfort
level
(LDL),
extended
high-frequency
loss
(EHFHL),
summating
potential
(SP)/action
(AP)
ratio,
distortion
product
otoacoustic
emission
(DPOAE),
thresholds
auditory
brainstem
response
(ABR)
wave
V,
somatic
modulation,
psychiatric
symptoms,
such
as
anxiety,
depression,
stress
evaluated
questionnaires.Decreased
LDL
(n
=
48,
59.8%)
the
most
frequent
finding,
followed
EHFHL
29,
35.4%),
increased
SP/AP
ratio
27,
32.9%),
symptoms
24,
29.3%),
decreased
DPOAE
17,
20.7%),
modulation
8,
9.8%),
ABR
threshold
3,
3.7%);
75.6%
had
one
or
more
these
findings.
presence
independently
associated
Tinnitus
Handicap
Inventory
(THI)
score.Tinnitus
may
be
accompanied
a
combination
various
subclinical
abnormal
audiological
However,
alone
distress.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Март 8, 2022
Abstract
We
performed
magnetic
resonance
spectroscopy
(MRS)
on
healthy
individuals
with
tinnitus
and
no
hearing
loss
(
n
=
16)
vs.
a
matched
control
group
17)
to
further
elucidate
the
role
of
excitatory
inhibitory
neurotransmitters
in
tinnitus.
Two-dimensional
J-resolved
(2D-JPRESS)
was
applied
disentangle
Glutamate
(Glu)
from
Glutamine
estimate
GABA
levels
two
bilateral
voxels
primary
auditory
cortex.
Results
indicated
lower
Glu
concentration
(large
effect)
right
cortex
(medium
left
group.
Within
group,
positively
correlated
loudness
measures.
While
difference
between
groups
is
line
former
findings
theories
about
dysfunctional
inhibition
system
tinnitus,
novel
finding
reduced
came
as
surprise
discussed
context
putative
framework
mechanisms
related
throughout
pathway.
Longitudinal
or
interventional
studies
could
shed
more
light
interactions
causality
neurochemistry.
Current Opinion in Otolaryngology & Head & Neck Surgery,
Год журнала:
2022,
Номер
30(5), С. 321 - 325
Опубликована: Июль 5, 2022
Purpose
of
review
The
purpose
this
is
to
offer
a
concise
summary
current
knowledge
regarding
hidden
hearing
loss
(HHL)
and
describe
the
variety
mechanisms
that
contribute
its
development.
We
will
also
discuss
various
diagnostic
tools
are
available
as
well
future
directions.
Recent
findings
Hidden
often
called
cochlear
synaptopathy
affects
afferent
synapses
inner
hair
cells.
This
description
in
contrast
traditional
models
loss,
which
predominantly
auditory
In
HHL,
nerve
fibres
with
slow
spontaneous
firing
rate,
crucial
for
locating
sound
background
noise,
severely
impaired.
addition,
recent
research
suggests
HHL
may
be
related
demyelination.
Noise
exposure
causes
myelin
sheath
thickness.
Auditory
brainstem
response,
envelope-following
response
middle-ear
muscle
reflex
promising
tests,
but
they
have
yet
validated
humans.
Summary
Establishing
humans
important
better
understand
patient
population,
predict
long-term
outcomes
allow
patients
take
necessary
protective
precautions.
The Journal of the Acoustical Society of America,
Год журнала:
2023,
Номер
153(1), С. 711 - 722
Опубликована: Янв. 1, 2023
A
series
of
articles
discussing
advanced
diagnostics
that
can
be
used
to
assess
noise
injury
and
associated
noise-induced
hearing
disorders
(NIHD)
was
developed
under
the
umbrella
United
States
Department
Defense
Hearing
Center
Excellence
Pharmaceutical
Interventions
for
Loss
working
group.
The
overarching
goals
current
were
provide
insight
into
(1)
well-established
more
recently
metrics
are
sensitive
detection
cochlear
pathology
or
diagnosis
NIHD,
(2)
tools
available
characterizing
individual
hazard
as
personal
exposure
will
vary
based
on
distance
sound
source
placement
protection
devices.
In
addition
utility
in
patient
care
settings,
discuss
selection
outcomes
end
points
considered
use
clinical
trials
investigating
loss
prevention
rehabilitation.
Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 7, 2025
More
than
5%
of
the
global
population
suffers
from
disabling
hearing
loss,
primarily
sensorineural
loss
(SNHL).
SNHL
is
often
caused
by
factors
such
as
vascular
disorders,
viral
infections,
ototoxic
drugs,
systemic
inflammation,
age-related
labyrinthine
membrane
degeneration,
and
noise-induced
(NIHL).
NIHL,
in
particular,
leads
to
changes
blood-labyrinth-barrier
(BLB)
physiology,
increased
permeability,
various
health
issues,
including
cardiovascular
disease,
hypertension,
diabetes,
neurological
adverse
reproductive
outcomes.
Recent
advances
neuromodulation
vector-based
approaches
offer
hope
for
overcoming
biological
barriers
BLB
development
innovative
treatments.
Computational
methods,
molecular
docking,
dynamics
simulations,
QSAR/QSPR
analysis
with
machine/deep
learning
algorithms,
network
pharmacology,
hold
potential
identifying
drug
candidates
optimizing
their
interactions
transporters,
glutamate
transporter.
This
paper
provides
an
overview
focusing
on
its
pathophysiology;
impact
ion
channels,
structures;
associated
symptoms,
comorbidities,
emerging
therapeutic
approaches.
advancements
strategies
show
great
promise
BLB,
facilitating
treatment
options.
The
primary
aim
this
review
examine
NIHL
detail
explore
underlying
mechanisms,
physiological
effects,
cutting-edge
effective
management
prevention.
Frontiers in Neurology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 22, 2022
Accumulating
evidence
suggests
a
role
of
the
brainstem
in
tinnitus
generation
and
modulation.
Several
studies
chronic
patients
have
reported
latency
amplitude
changes
different
peaks
auditory
response,
possibly
reflecting
neural
or
altered
activity.
The
aim
systematic
review
was
to
assess
if
alterations
within
are
reflected
short-
middle-latency
evoked
potentials
(AEPs).
The Journal of the Acoustical Society of America,
Год журнала:
2023,
Номер
153(1), С. 436 - 445
Опубликована: Янв. 1, 2023
The
middle
ear
muscle
reflex
(MEMR)
in
humans
is
a
bilateral
contraction
of
the
stapedial
response
to
moderate-to-high
intensity
acoustic
stimuli.
Clinically,
MEMR
thresholds
have
been
used
for
differential
diagnosis
otopathologies
decades.
More
recently,
changes
amplitude
or
threshold
proposed
as
an
assessment
noise-induced
synaptopathy,
subclinical
form
cochlear
damage
characterized
by
suprathreshold
hearing
problems
that
occur
function
inner
hair
cell
(IHC)
synaptic
loss,
including
hearing-in-noise
deficits,
tinnitus,
and
hyperacusis.
In
animal
models,
wideband
immittance
correlated
with
synaptopathy;
however,
studies
shown
more
varied
results.
discrepancies
observed
across
could
reflect
heterogeneity
synaptopathy
than
effects
parametric
differences
relative
sensitivity
measurement.
Whereas
etiology
degree
can
be
carefully
controlled
likely
stems
from
multiple
etiologies
thus
vary
greatly
population.
Here,
we
explore
evolving
research
evidence
relation
early
correlate
deficits.
