The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation

Toxics, Год журнала: 2025, Номер 13(3), С. 193 - 193

Опубликована: Март 8, 2025

Zinc contamination in aquatic environments has become a growing concern due to its potential bioaccumulate and induce neurotoxic effects organisms. As an essential trace element, zinc plays crucial role various physiological processes, but excessive exposure can disrupt the gut–brain axis, leading cognitive behavioral impairments. Recent studies have suggested that probiotics may offer protective against environmental neurotoxins by modulating gut microbiota associated neurological functions. The zebrafish (Danio rerio) emerged as valuable model organism for studying biological mechanisms underlying neurotoxicity therapeutic interventions. This study aimed assess of on impairments induced chloride (ZnCl2) zebrafish. Specifically, were exposed ZnCl2 at concentrations 0.5 mg/L 1.0 96 h, followed 7-day post-exposure period (Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus). these is already known neuromotor deficits resembling Alzheimer’s disease-like symptoms models, making it suitable evaluating neuroprotective probiotics. Behavioral assessments including sociability tests along with short- long-term memory evaluations conducted using EthoVision XT 16 software. Memory demonstrated impaired functions, while probiotic treatment did not significantly ameliorate deficits. In social behavior test, resulted marked decrease sociability, whereas significant changes. However, administration following intoxication exhibited anxiolytic effect These findings suggest exhibit partial neurobehavioral benefits chloride-induced toxicity, particularly mitigating anxiety-like behaviors rather than Further investigations are needed elucidate precise which interact axis context heavy metal neurotoxicity.

Язык: Английский

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The microbiome: what a neurologist needs to know

Practical Neurology, Год журнала: 2025, Номер unknown, С. pn - 004400

Опубликована: Март 12, 2025

The gastrointestinal tract is inhabited by trillions of micro-organisms that form the gut microbiome, which serves various functions can influence neurological pathways. It release metabolites could affect nervous system. bidirectional communication between intestine and central system known as gut–brain axis. This be impacted microbiota in direct indirect ways. There has been a suggested connection microbiome many disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease multiple sclerosis. explored human animal studies. While no microbial biomarkers have identified yet, alterations several taxa to associated with states. potential modulate function sparked clinical trials using gut-altering treatments, some positive preliminary results.

Язык: Английский

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In vitro colonic fermentation of clean label ham formulations: Gut microbiota modulation and metabolite production

Food Research International, Год журнала: 2025, Номер unknown, С. 116287 - 116287

Опубликована: Март 1, 2025

Consumer wishes for "clean label" products have prompted the rise of these available in market. With dietary choices directly influencing market trends, developing novel meat with natural nitrate and nitrite alternatives is a sought-after premise. Cured meats like ham been under scrutiny due to their potential harm human health, having sodium theorised trigger dysbiosis gut microbiota impair faecal short-chain fatty acids (SCFAs) production. Four formulations source coupled nitrate-reducing starter cultures were subjected an vitro gastrointestinal digestion simulation (INFOGEST) followed by colonic fermentation. The impact each formulation on fermentation metabolites, namely SCFAs, was assessed quantitative Next Generation Sequencing High-Performance Liquid Chromatography, respectively. No significant differences found SCFAs levels or microbial communities throughout Further research should provide insight into how can be associated nitrosamine formation. benefits need thoroughly demonstrated. While solutions are often considered preferable traditional nitrite-containing products, implementation approached caution. In addition antimicrobial efficacy consumer acceptance, it essential assess product cost compare performance health (positive negative) that formulations. Extensive needed ensure any move based solid evidence rather than trends.

Язык: Английский

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Multi-site investigation of gut microbiota in CDKL5 deficiency disorder mouse models: Targeting dysbiosis to improve neurological outcomes

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115546 - 115546

Опубликована: Апрель 1, 2025

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental often associated with gastrointestinal (GI) issues and subclinical immune dysregulation, suggesting link to the gut microbiota. We analyze fecal microbiota composition in two CDKL5 knockout (KO) mouse models at postnatal days (P) 25, 32 (youth), 70 (adulthood), revealing significant microbial imbalances, particularly during juvenile stages. To investigate role of intestinal CDD assess causality, we administer antibiotics, which lead improved visual cortical responses reduce hyperactivity. Additionally, microglia morphology changes, indicative altered surveillance activation states, are reversed. Strikingly, transplantation from KO wild-type (WT) recipient mice successfully transfers both response deficits hyperactive behavior. These findings show that alterations contribute severity neurological symptoms CDD, shedding light on interplay between microbiota, microglia, outcomes.

Язык: Английский

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Disruption in the human microbiome causing behavioural changes in bipolar disorder

International review of neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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