Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 12841 - 12841

Опубликована: Окт. 25, 2022

Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are major pathological features an brain. These proteins highly expressed nerve cells found most tissues. Tau primarily provides stabilization to microtubules part axons dendrites. However, tau a state becomes hyperphosphorylated, causing dysfunction synaptic impairment degeneration neurons. This article presents summary role tau, phosphorylated (p-tau) AD, other tauopathies. Tauopathies, including Pick’s disease, frontotemporal dementia, corticobasal degeneration, argyrophilic grain progressive supranuclear palsy, Huntington’s result misprocessing accumulation within neuronal glial cells. also focuses on current research post-translational modifications genetics pathology, tauopathies development new drugs targeting p-tau, therapeutics for treating possibly preventing

Язык: Английский

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Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches

Neuroscience, Год журнала: 2025, Номер 572, С. 1 - 10

Опубликована: Март 5, 2025

Язык: Английский

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Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117277 - 117277

Опубликована: Авг. 9, 2024

Язык: Английский

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The pathophysiological signaling and efficacy of medicinal herbal compounds in Alzheimer’s disease

Deleted Journal, Год журнала: 2025, Номер 29(1), С. 3 - 24

Опубликована: Март 1, 2025

Язык: Английский

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Nature's toolbox against tau aggregation: An updated review of current research

Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101924 - 101924

Опубликована: Март 31, 2023

Язык: Английский

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Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2023, Номер 2(3), С. 22 - 40

Опубликована: Июнь 11, 2023

Neuroinflammation is a characteristic sign of wide variety neurodegenerative diseases, including Alzheimer's and Parkinson's, amongst others. Microglia, which are native immune cells found in the brain, become activated very quickly response to brain infection or injury. When microglia overactivated, their production pro-inflammatory cytotoxic chemicals can unregulated uncontrolled, primary cause neuroinflammation. Microglia principally responsible for As result, investigation novel approaches reduce neuroinflammatory reactions an essential component disease treatment. In research inflammation, bacterial lipopolysaccharide frequently used. This compound initiation number significant cellular processes that significantly contribute pathophysiology

Язык: Английский

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Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 1, 2023

Delphinium roylei Munz is an indigenous medicinal plant to India where its activity against cancer has not been previously investigated, and specific interactions of bioactive compounds with vulnerable breast drug targets remain largely unknown. Therefore, in the current study, we aimed evaluate anti-breast different extracts D. deciphering molecular mechanism by Network Pharmacology combined Molecular Docking vitro verification. The experimental was extracted various organic solvents according their polarity index. Phytocompounds were identified High resolution-liquid chromatography-mass spectrometry (HR-LC/MS) technique, SwissADME programme evaluated physicochemical properties. Next, target(s) associated obtained bioactives or cancer-related retrieved public databases, Venn diagram selected overlapping targets. networks between visualized, constructed, analyzed STRING Cytoscape software. Finally, implemented a docking test (MDT) using AutoDock Vina explore key compound(s). HR-LC/MS detected hundreds phytocompounds, few accepted Lipinski’s rules after virtual screening therefore classified as drug-like (DLCs). A total 464 potential target genes attained for nine quantitative phytocompounds Gene Cards, OMIM DisGeNET platforms, 12063 disease linked retrieved. With Kyoto Encyclopaedia Genes Genomes (KEGG) pathway enrichment, 20 signalling pathways manifested, hub (PI3K-Akt pathway), (Akt1), compound (8-Hydroxycoumarin) among via studies. investigation revealed that phytoconstituents, 8-hydroxycoumarin showed best binding energy (−9.2 kcal/mol) Akt1 target. followed all ADME property prediction SwissADME, 100 nanoseconds (ns) MD simulations complexes found be stable. Furthermore, also significant antioxidant anticancer through Our findings indicated first time could used treatment BC.

Язык: Английский

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The Bioactivity and Phytochemicals of Muscari comosum (Leopoldia comosa), a Plant of Multiple Pharmacological Activities

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2592 - 2592

Опубликована: Фев. 23, 2024

Leopoldia comosa (LC), popularly known as Muscari comosum, spontaneously grows in the Mediterranean region and its bulbs are used a vegetable. Traditionally, they also to treat various diseases conditions, which has inspired study of pharmacological activities different parts LC. These studies revealed numerous biological properties LC including antioxidant, anti-inflammatory, anti-diabetes, anti-obesity, anti-cancer, anti-Alzheimer's disease, antibacterial, immune stimulant. High antioxidant activity compared other non-cultivated plants, potential role reported make an excellent candidate be developed plant against important associated diseases. The presence diverse class phytochemicals (n = 85), especially flavonoids homoisoflavones, LC, imparts significance nutraceutical candidature plant. However, limited animal lack directional approach have further design effective clinical for development current is first attempt comprehensively compile information regarding emphasize targets/markers targeted by activities, highlight gaps propose possible bridges therapeutic and/or supplement

Язык: Английский

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Natural products targeting amyloid-β oligomer neurotoxicity in Alzheimer's disease

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 276, С. 116684 - 116684

Опубликована: Июль 14, 2024

Язык: Английский

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Neuroprotective Potential of Biflavone Ginkgetin: A Review

Life, Год журнала: 2023, Номер 13(2), С. 562 - 562

Опубликована: Фев. 16, 2023

Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin first known biflavonoid, a dimer isolated ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in than 20 different plant species, most of which their use traditional medicine. Herein we summarized data on neuroprotective potential ginkgetin. There evidence protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), Parkinson’s (PD). Beneficial effects strokes been demonstrated animal studies injection ginkgetin before or after onset stoke showed damage. AD has studied to date. Possible mechanisms include inhibition reactive oxygen β-secretase, Aβ fibril formation, amelioration inflammation, antimicrobial activity. also positive relief PD symptoms studies. Most available vitro vivo studies, where results, further clinical should be conducted.

Язык: Английский

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