Photobiomodulation Photomedicine and Laser Surgery,
Год журнала:
2024,
Номер
42(1), С. 54 - 65
Опубликована: Янв. 1, 2024
Background:
Drug
addiction
refers
to
a
maladaptive
pattern
of
drug
use
that
frequently
leads
substance
abuse
problems
and
accompanying
cognitive
behavioral
symptoms.
Among
the
crucial
criteria
addiction,
craving
stands
out
as
potent
factor
contributing
ongoing
relapse
following
period
abstinence.
To
date,
there
is
no
definitive
method
for
eradicating
opioid
cravings.
The
introduction
novel
neurocognitive
interventions,
such
rehabilitation
photobiomodulation
(PBM),
into
realm
psychiatric
treatments
holds
promise
due
parallels
between
other
disorders.
These
innovative
techniques
offer
potential
value
in
addressing
addiction.
Objective:
This
study
aimed
assess
compare
efficacy
PBM
alleviating
cravings
among
individuals
undergoing
treatment
clinical
settings.
Methods:
research
used
randomized
trial
chosen
method.
statistical
population
encompassed
all
clients
receiving
at
clinics,
selected
through
convenience
sampling
method,
with
α
=
0.05
significance
level
an
effect
size
85%.
Gpower
software
was
utilized
determine
three
equal
groups.
Sixty-three
participants,
each
having
mean
total
score
higher
than
3
5
on
Desire
Questionnaire
(DDQ),
were
randomly
assigned
two
experimental
groups
(n
21
each)
control
group
21).
For
assessment
immediate
periodic
craving,
DDQ
Obsessive
Compulsive
Use
Scale
used.
In
low-level
laser
group,
810
nm
wavelength
continuous
irradiation
applied
twice
week
distance
1
cm
by
prefrontal
part
brain
duration
6
weeks
(12
sessions).
stop
signal
n-back
tasks
(comprising
12
sessions,
lasting
30
min).
Results:
results
demonstrated
intervention
significantly
reduced
both
post-test
follow-up
phases
compared
group.
Bonferroni
post
hoc
test
indicated
more
effective
terms
working
memory
(WM)
inhibitory
reducing
(p
<
0.05).
Conclusions:
While
targeting
WM
effectively
therapy
proved
be
this
regard.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10977 - 10977
Опубликована: Июль 1, 2023
Increasing
evidence
indicates
that
photobiomodulation,
based
on
tissue
irradiation
with
photons
in
the
red
to
near-infrared
spectrum,
may
be
an
effective
therapeutic
approach
central
nervous
system
disorders.
Although
functionality
has
been
shown
affected
by
animal
models,
as
well
preliminary
healthy
subjects
or
patients
neuropsychiatric
disorders,
mechanisms
involved
photobiomodulation
effects
have
not
yet
clarified.
We
previously
observed
could
stimulate
glutamate
release.
Here,
we
investigate
potentially
glutamate-releasing
effect
of
from
adult
mouse
cerebrocortical
nerve
terminals.
report
photon
ability
induce
exocytotic
vesicular
release
terminals
glutamatergic
neurons
a
power-dependent
way.
It
can
hypothesized
depending
potency,
neurotoxic
physiological
range.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 31, 2024
Depression
is
a
common
mental
illness
that
widely
recognized
by
its
lack
of
pleasure,
fatigue,
low
mood,
and,
in
severe
cases,
even
suicidal
tendencies.
Photobiomodulation
(PBM)
non-invasive
neuromodulation
technique
could
treat
patients
with
mood
disorders
such
as
depression.
A
systematic
search
ten
databases,
including
randomized
controlled
trials
(RCTs)
for
depression,
was
conducted
from
the
time
library
construction
to
September
25,
2023.
The
primary
outcome
secondary
sleep.
Meta-analysis
performed
using
RevMan
(version
5.4)
and
Stata
14.0).
Subgroup
analyses
were
identify
sources
heterogeneity.
certainty
evidence
assessed
Grading
Recommendations
Assessment,
Development,
Evaluation
(GRADE).
Three
thousand
two
hundred
sixty-five
studies
retrieved
database
screened
inclusion
eleven
trials.
forest
plot
results
demonstrated
PBM
alleviated
depression
(SMD
=
-0.55,
95%
CI
[-0.75,
-0.35],
I2
46%).
But
it
not
statistically
significant
patients'
sleep
outcomes
-0.82,
[-2.41,
0.77],
0%,
p
>
0.05).
analysis
showed
s-PBM
superior
t-PBM
relieving
symptoms
best
improvement
achieved
wavelength
823
nm,
fluence
10-100
J/cm2,
irradiance
50-100
mW/cm2,
30
min,
treatment
frequency
<
3/week,
number
treatments
>15
times.
808
≤1
≤
5
≥
All
had
quality
either
moderate
or
very
low,
there
no
bias
publication.
We
conclude
effective
reducing
patients.
However,
current
small,
further
are
needed
extend
results.
https://www.crd.york.ac.uk/PROSPERO/,
CRD42023444677.
Journal of lasers in medical sciences,
Год журнала:
2023,
Номер
14, С. e55 - e55
Опубликована: Ноя. 11, 2023
Introduction:
Low-level
laser
therapy
(LLLT),
also
called
Photobiomodulation,
has
gained
widespread
acceptance
as
a
mainstream
modality,
particularly
in
the
form
of
photobiostimulation
(PBM).
Here
our
review,
we
aim
to
present
application
LLLT
help
with
depression,
explore
potential
action
mechanisms
and
pathways,
discuss
existing
limitations,
address
challenges
associated
its
clinical
implementation.
Methods:
In
biological
systems,
visible
light
wavelength
range
400-700
nm
activates
photoreceptors
involved
vision
circadian
rhythm
regulation.
The
near-infrared
(NIR)
800-1100
exhibits
superior
tissue
penetration
capabilities
compared
light,
which
enables
non-invasive
various
tissues.
Results:
By
enhancing
adenosine
triphosphate
(ATP)
production
using
respiratory
chain,
is
able
enhance
blood
flow,
reduce
inflammation,
support
repair
healing,
stem
cell
growth
proliferation.
Preclinical
studies
animal
models
have
shown
promising
neuroprotective
effects
method
on
central
nervous
system
(CNS)
diseases,
suggesting
improvements
brain
function
for
patients
suffering
from
Alzheimer's
disease.
addition,
it
helps
Parkinson's
their
movement
problems
ameliorates
mental
disorders
individuals
depression.
Conclusion:
patients'
quality
life
can
be
significantly
enhanced.
A
comprehensive
understanding
protective
underlying
will
facilitate
therapeutic
future.
Photobiomodulation Photomedicine and Laser Surgery,
Год журнала:
2024,
Номер
42(1), С. 54 - 65
Опубликована: Янв. 1, 2024
Background:
Drug
addiction
refers
to
a
maladaptive
pattern
of
drug
use
that
frequently
leads
substance
abuse
problems
and
accompanying
cognitive
behavioral
symptoms.
Among
the
crucial
criteria
addiction,
craving
stands
out
as
potent
factor
contributing
ongoing
relapse
following
period
abstinence.
To
date,
there
is
no
definitive
method
for
eradicating
opioid
cravings.
The
introduction
novel
neurocognitive
interventions,
such
rehabilitation
photobiomodulation
(PBM),
into
realm
psychiatric
treatments
holds
promise
due
parallels
between
other
disorders.
These
innovative
techniques
offer
potential
value
in
addressing
addiction.
Objective:
This
study
aimed
assess
compare
efficacy
PBM
alleviating
cravings
among
individuals
undergoing
treatment
clinical
settings.
Methods:
research
used
randomized
trial
chosen
method.
statistical
population
encompassed
all
clients
receiving
at
clinics,
selected
through
convenience
sampling
method,
with
α
=
0.05
significance
level
an
effect
size
85%.
Gpower
software
was
utilized
determine
three
equal
groups.
Sixty-three
participants,
each
having
mean
total
score
higher
than
3
5
on
Desire
Questionnaire
(DDQ),
were
randomly
assigned
two
experimental
groups
(n
21
each)
control
group
21).
For
assessment
immediate
periodic
craving,
DDQ
Obsessive
Compulsive
Use
Scale
used.
In
low-level
laser
group,
810
nm
wavelength
continuous
irradiation
applied
twice
week
distance
1
cm
by
prefrontal
part
brain
duration
6
weeks
(12
sessions).
stop
signal
n-back
tasks
(comprising
12
sessions,
lasting
30
min).
Results:
results
demonstrated
intervention
significantly
reduced
both
post-test
follow-up
phases
compared
group.
Bonferroni
post
hoc
test
indicated
more
effective
terms
working
memory
(WM)
inhibitory
reducing
(p
<
0.05).
Conclusions:
While
targeting
WM
effectively
therapy
proved
be
this
regard.
