Role of ginsenosides in bone remodelling: A narrative review on molecular mechanism DOI Open Access
Ankur Joshi, Soni Priyanka,

Verma Poojashree

и другие.

International Journal of Pharmaceutical Chemistry and Analysis, Год журнала: 2024, Номер 11(3)

Опубликована: Сен. 15, 2024

Osteoporosis (OP) is a metabolic bone disease that impacts large number of humanity. Degeneration the microstructure, loss mass, and heightened fragility are symptoms. The primary reason because rates formation resorption different. Extensive research on effects ginsenoside, component ginseng used in traditional Indian medicine, osteoporosis has shown promising results. There were forty-four articles written about ginsenosides, osteoblasts, osteoclasts, osteoporosis, mesenchymal cells. ginsenosides osteoblast, osteoclast, stem cell activity remodelling their potential role preventing focus these studies. This in-depth study sheds light several to treat from different perspectives, paving way for therapeutic applications future.

Язык: Английский

Spinal cord injury: molecular mechanisms and therapeutic interventions DOI Creative Commons
Xiao Hu, Wei Xu, Yilong Ren

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 26, 2023

Abstract Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties neural regeneration in central nervous system. In past few decades, researchers have attempted to completely elucidate mechanism identify effective strategies promote axon circuit remodeling, but results not been ideal. Recently, new SCI, especially interactions between immune cell responses, revealed by single-cell sequencing spatial transcriptome analysis. With development bioactive materials stem cells, more attention has focused on forming intermediate networks reconstruction than promoting axonal corticospinal tract. Furthermore, technologies control physical parameters such as electricity, magnetism ultrasound constantly innovated applied fate regulation. Among these advanced novel technologies, therapy, biomaterial transplantation, electromagnetic stimulation entered into stage clinical trials, some them already treatment. this review, we outline overall epidemiology pathophysiology expound latest research progress related detail, propose future directions for applications.

Язык: Английский

Процитировано

309
Advances in molecular therapies for targeting pathophysiology in spinal cord injury DOI Creative Commons

Ha Neui Kim,

Madeline Rose McCrea,

Shuxin Li

и другие.

Expert Opinion on Therapeutic Targets, Год журнала: 2023, Номер 27(3), С. 171 - 187

Опубликована: Март 4, 2023

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each year and there is no cure for SCI patients currently. The primary damages spinal tissues secondary mechanisms, including ischemia, apoptosis, inflammation, astrogliosis, further exacerbate lesions to cord. Recently, researchers have designed various therapeutic approaches by targeting its major cellular or molecular pathophysiology.Areas covered Some strategies shown promise in repairing injured functional recoveries, such as administering neuroprotective reagents, specific genes promote robust axon regeneration of disconnected fiber tracts, epigenetic factors enhance cell survival neural repair, facilitating neuronal relay pathways neuroplasticity restoration function after SCI. This review focuses on advances preclinical therapies reported recent years.Expert opinion Recent progress developing novel effective encouraging, but many challenges remain future design treatments, highly neuroprotectants early interventions, stimulating with synaptic reconnections among neurons, maximizing recovery lost functions combination strategies, translating most promising into human use.

Язык: Английский

Процитировано

13
Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway DOI Creative Commons

Shiyuan Yin,

Feiyun Xia, Wenjun Zou

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 334, С. 118531 - 118531

Опубликована: Июль 5, 2024

Ginseng (Panax ginseng C. A. Mey) is a common traditional Chinese medicine used for anti-inflammation, anti-apoptosis, anti-oxidative stress, and neuroprotection. Ginsenosides Rg1, the main active components isolated from ginseng, may be feasible therapy spinal cord injury (SCI).

Язык: Английский

Процитировано

5
Ginsenoside in the treatment of type 2 diabetes and its complications: a promising traditional chinese medicine DOI Creative Commons

Yingying Liu,

Yang Ju, Yanjun Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 13, 2025

Type 2 diabetes mellitus (T2DM), a chronic condition commonly observed in adults, particularly among the elderly, is characterized by dysfunctional insulin response that impairs blood glucose regulation, resulting persistent hyperglycemia. Ginseng, medicinal plant with significant economic value and longstanding history of therapeutic use Asia, has shown efficacy against various diseases. Extensive clinical experimental studies highlight ginsenosides, its primary bioactive compounds, for their multiple effects across range conditions, including endocrine, cardiovascular, central nervous system disorders. Various ginsenoside types have demonstrated potential lowering levels, reducing resistance, alleviating complications through modulation key protein targets signaling pathways. This review consolidates pharmacological actions mechanisms distinct ginsenosides managing complications, offering theoretical foundation further research novel drug development T2DM treatment, while also providing robust support future applications.

Язык: Английский

Процитировано

0
Therapeutic effects of ginsenosides on osteoporosis for novel drug applications DOI Creative Commons
Rui Liu,

Lixia Xu,

Lin-Jian Tong

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер 974, С. 176604 - 176604

Опубликована: Апрель 20, 2024

Osteoporosis (OP) is a metabolic bone disease with high incidence rate worldwide. Its main features are decreased mass, increased fragility and deterioration of microstructure. It caused by an imbalance between formation resorption. Ginsenoside safe effective traditional Chinese medicine (TCM) usually extracted from ginseng plants, having various therapeutic effects, which the effect against osteoporosis has been extensively studied. We searched total 44 relevant articles using keywords including osteoporosis, ginsenosides, mesenchymal cells, osteoblasts, osteoclasts remodeling, all investigated cellular mechanisms different types ginsenosides affecting activity remodeling stem osteoblasts to counteract osteoporosis. This review describes used treat perspectives, providing solid theoretical basis for future clinical applications.

Язык: Английский

Процитировано

2
Mechanism of Valeriana Jatamansi Jones for the treatment of spinal cord injury based on network pharmacology and molecular docking DOI Creative Commons
Yunyun Wang, Jiachun Lü, Hua Xiao

и другие.

Medicine, Год журнала: 2023, Номер 102(50), С. e36434 - e36434

Опубликована: Дек. 15, 2023

Spinal cord injury (SCI) is characterized by high rates of disability and death. Valeriana jatamansi Jones (VJJ), a Chinese herbal medicine, has been identified to improve motor function recovery in rats with SCI. The study aimed analyze the potential molecular mechanisms action VJJ treatment main ingredients were obtained from literature SwissADME platform was used screen active ingredients. Swiss TargetPrediction predict targets VJJ, SCI GeneCards OMIM databases. intersecting genes considered protein-protein interaction network constructed using STRING database hub for screened according their degree values. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes enrichment analyses performed Metascape database. Cytoscape software construct "herb-ingredient-target-pathway" network. Preliminary validation docking via Auto Dock Vina software. A total 56 mainly iridoids, identified. There 1493 GO items (P < .01) 173 signaling pathways enrichment, including phosphoinositide-3-kinase (PI3K)-protein kinase B (Akt) pathway, hypoxia-inducible factor 1 tumor necrosis pathway. Molecular revealed that 12 enriched PI3K/Akt pathway had binding affinity ingredient VJJ. may exert its therapeutic effects on through iridoid fraction, acting signal transducer activator transcription 3, CASP3, AKT1, factor, mammalian target rapamycin, interleukin 6, other genes, which be related

Язык: Английский

Процитировано

5
Investigating the protective properties of Panax ginseng and its constituents against biotoxins and metal toxicity: a mechanistic review DOI
Maryam Rameshrad, Zahra Memariani, Karim Naraki

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

1
Falcarindiol Improves Functional Recovery and Alleviates Neuroinflammation after Spinal Cord Injury by Inhibiting STAT/MAPK Signaling Pathways DOI Creative Commons
Lin Cao, Xiaoli Huang,

Jian Zhu

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 736, С. 150860 - 150860

Опубликована: Окт. 20, 2024

Язык: Английский

Процитировано

1
Role of ginsenosides in bone remodelling: A narrative review on molecular mechanism DOI Open Access
Ankur Joshi, Soni Priyanka,

Verma Poojashree

и другие.

International Journal of Pharmaceutical Chemistry and Analysis, Год журнала: 2024, Номер 11(3)

Опубликована: Сен. 15, 2024

Osteoporosis (OP) is a metabolic bone disease that impacts large number of humanity. Degeneration the microstructure, loss mass, and heightened fragility are symptoms. The primary reason because rates formation resorption different. Extensive research on effects ginsenoside, component ginseng used in traditional Indian medicine, osteoporosis has shown promising results. There were forty-four articles written about ginsenosides, osteoblasts, osteoclasts, osteoporosis, mesenchymal cells. ginsenosides osteoblast, osteoclast, stem cell activity remodelling their potential role preventing focus these studies. This in-depth study sheds light several to treat from different perspectives, paving way for therapeutic applications future.

Язык: Английский

Процитировано

0