Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury DOI Creative Commons
Mariusz Siemiński,

Michalina Reimus,

Maria Kałas

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 25 - 25

Опубликована: Дек. 28, 2024

Traumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage tissue. Primary an immediate and, therefore, rather irreversible effect of trauma, while secondary results complex cascade pathological processes, among which oxidative stress and neuroinflammation are most prominent. As TBI significant cause mortality disability, with high social costs all over world, any form therapy that may mitigate trauma-evoked desirable. Melatonin, sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant anti-inflammatory effects well tolerated when used as drug. Due these properties, it very reasonable consider melatonin potential therapeutic molecule for treatment. This review summarizes data in vitro studies, animal models, clinical trials focus on usage TBI.

Язык: Английский

In Situ Sprayed Self‐Gelling Powder Self‐Assembled by a Pure Molecular Drug from Herbal Extract for Rapid Hemostasis and Neuroprotection in Traumatic Brain Injury DOI Open Access
Teng Li, Jun Zheng,

Mingyue Xia

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Immediate hemostasis and effective treatment are foremost for acute intervention in traumatic brain injury (TBI), but the therapeutic tools professional methods often lacking at scene. Self‐gelling powders formed by self‐assembly of pure molecular drugs can quickly deliver hemostatic effects without complications from chemical modifications or additional carriers. However, no clinical have been reported as a self‐gelling powder this purpose. Here, is self‐assembled sodium aescinate (SA), drug already approved treating trauma. To generate SA (SA self‐gel‐P), heated cooled an alkaline solution to form hydrogel, then freeze‐dried ground. The obtained self‐gel‐P has good hydrophilicity. When sprayed onto bleeding site after TBI, it rapidly absorbed blood gel through intermolecular hydrogen bonding, facilitating situ sealing rapid hemostasis. Furthermore, hydrogel released over long period, which helped reduce neuronal death, improve integrity blood‐brain barrier, edema, alleviate neuroinflammation, ultimately promote recovery neurofunction significant toxic side effects. This may serve powerful auxiliary tool pre‐hospital TBI.

Язык: Английский

Процитировано

0
Counteracting immunodepression by extracellular matrix hydrogel to promote brain tissue remodeling and neurological function recovery after traumatic brain injury DOI Creative Commons
Bixue Wang,

qiaoping zhang,

Changsheng Liu

и другие.

Biomaterials, Год журнала: 2025, Номер 318, С. 123181 - 123181

Опубликована: Фев. 8, 2025

Язык: Английский

Процитировано

0
From Microsphere Synthesis to Neural Tissue Regeneration: Unraveling the Potentials and Progress DOI
Yaqiong Liu,

Yuqing Shang,

Zhen Wang

и другие.

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112363 - 112363

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
An innovative and mass-sensitive Quartz Tuning Fork (QTF) biosensor for GFAP detection: A novel approach for Traumatic Brain Injury diagnosis DOI Creative Commons
Burcu Özcan,

İnci Uludağ Anıl,

Mehmet Altay Ünal

и другие.

Biosensors and Bioelectronics X, Год журнала: 2025, Номер unknown, С. 100614 - 100614

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
A novel and mass-sensitive quartz tuning fork platform for glial fibrillary acidic protein determination DOI
Burcu Özcan, İnci Uludağ, Mehmet Altay Ünal

и другие.

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113408 - 113408

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway DOI
Dan Wang, Hongyu Sun,

Kerong Hai

и другие.

Toxicology Mechanisms and Methods, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Апрель 2, 2025

Traumatic brain injury (TBI), a prevalent neurological disorder in clinical practice, is primarily induced by external trauma. Propofol has been reported to alleviate the symptoms associated with TBI. In this study, TBI model was established mice using controlled cortical impact (CCI) method. After treatment propofol and BML-275, neuronal damage assessed through modified Neurological Severity Score (mNSS), Hematoxylin Eosin (HE) staining, Nissl staining. To investigate role of AMPK/SIRT1 pathway propofol-regulated TBI, AMPKα-silenced vectors overexpressed SIRT1 were transfected. Western blot performed evaluate expression proteins involved pyroptosis markers. The regulatory Th17/Treg balance examined detecting key transcription factors RORγt FOXP3 immunofluorescent staining RT-qPCR. Enzyme-linked immunosorbent assay (ELISA) used measure IL-17 IL-10 concentrations. Results showed that significantly reduced model, an effect reversed BML-275. Moreover, mitigated downregulating Caspase-1 GSDMD-N post-TBI. inhibited Th17 differentiation while promoting Treg modulating RORγt/FOXP3 IL-17/IL-10 levels. Silencing AMPKα markedly diminished propofol's effects on differentiation, these being upon overexpression. suppressed regulation via activation pathway. These findings suggest exerts protective against following potentially modulation signaling

Язык: Английский

Процитировано

0
A review of bigels for neurotrauma therapeutics: Structural insights for tissue microenvironment alignment DOI

Botle Moswatsi,

Gillian Dumsile Mahumane, Pradeep Kumar

и другие.

Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214315 - 214315

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two‐Sample Mendelian Randomization Study DOI Creative Commons
Huan Wang, Yibin Huang,

Ziwen Zhu

и другие.

Health Science Reports, Год журнала: 2025, Номер 8(5)

Опубликована: Апрель 28, 2025

ABSTRACT Background The incidence of Parkinson's disease (PD) is significantly increased in older people who have experienced traumatic brain injury (TBI), suggesting that TBI may be a potential risk factor for PD. However, the causal relationship remains ambiguous. Objective To investigate association between and PD using Mendelian randomization (MR) analyses. Methods Four genome‐wide databases were reviewed detail, including GWAS Catalog, FinnGen, IEU OpenGWAS, UK Biobank. Genetic data obtained from FinnGen set, 7430 clinically diagnosed cases 404,751 controls, was meta‐analysis 42,792 568,693 controls. bidirectional two‐sample MR analyses used to Results There no evidence an (IVW; OR = 1.11; 95% CI, 0.91–1.36; p 0.308). Similarly, genetically predisposed not associated with high 0.96; 0.91–1.02; 0.209). MR‐Egger regression, weighted mode, median consistent those IVW analysis. Additional sensitivity further supported robustness our conclusions. Conclusions No found

Язык: Английский

Процитировано

0
Survival Outcomes and Predictive Factors of Mortality in Feline Epilepsy: A Comprehensive Retrospective Study DOI Creative Commons
Kreevith Prompinichpong, Nirut Suwanna, Vachira Hunprasit

и другие.

Animals, Год журнала: 2025, Номер 15(11), С. 1504 - 1504

Опубликована: Май 22, 2025

Epilepsy is the most common neurological disorder in cats. However, information on long-term outcomes and predictive survival factors based clinicopathological findings limited. We aimed to evaluate clinical manifestations, rates, hazard influencing cats with epilepsy by analyzing medical records of 90 diagnosed via brain magnetic resonance imaging (MRI). The were divided into non-survival groups. Univariate multivariable logistic regression analyses conducted identify significant factors. mortality rates at one two years 33.2% 37.8%, respectively. median age group 3 1 years, Age over 7 (p = 0.002), paresis 0.001), structural lesions 0.015), leukocytosis neutrophilia hyperproteinemia 0.037), hypoalbuminemia hyperglobulinemia 0.003), an elevated neutrophil-to-lymphocyte ratio 0.041), associated increased rate. A analysis identified several predictors early epilepsy, including 0.045), presence 0.012), 0.042), 0.005), 0.030). Older shown be key important for prognosis prediction management.

Язык: Английский

Процитировано

0
Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis DOI
Najmeh Motaghi, Amin Saberinia,

Hamideh Arvan

и другие.

Applied Neuropsychology Adult, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Июнь 2, 2025

Traumatic brain injury (TBI) is particularly common in low- and middle-income countries, disproportionately affecting youth. While around 80% of TBI cases are classified as mild, even these can lead to disabling symptoms. This study involved a comprehensive search for relevant articles published between 1934 2024 across multiple databases, utilizing specific keywords data collection. Bibliometric analyses were conducted using R VOSviewer tools evaluate the literature. The analysis included scientific machine learning evaluations TBI's pathophysiology, prognosis, consequences, such cognitive, behavioral, physical outcomes, well therapeutic interventions rehabilitation strategies. findings underscore need increased attention psychosocial consequences TBI. Evidence-based research guide efforts enhance quality life both patients caregivers. To improve options patients, collaborative essential support ongoing this area. By focusing on multidimensional effects TBI, we better address needs individuals living with long-term condition.

Язык: Английский

Процитировано

0