Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 323 - 331
Опубликована: Июль 22, 2024
Abstract
Given
the
rate
at
which
AI
is
developing,
and
risks
associated
with
artificial
sentience
taking
us
by
surprise,
we
should
apply
run-ahead
principle:
any
given
time,
measures
to
regulate
development
of
sentient
run
ahead
what
would
be
proportionate
posed
current
technology,
considering
also
credible
future
trajectories.
The
principle
may
potentially
justify
strong
regulatory
action,
but
a
moratorium
go
beyond
reasonably
necessary
manage
risk.
An
alternative
proposal,
involving
regular
testing
monitor
our
creations,
currently
unfeasible,
due
absence
tests
that
can
applied
large
language
models
other
systems
high
potential
for
gaming
criteria.
A
third
approach
involves
oversight
means
sector-wide
codes
good
practice
licensing
schemes.
This
path
require
greater
level
transparency
than
have
seen
from
industry
date.
overarching
imperative
democratic
debate
about
these
questions
now.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 19, 2024
Abstract
Can
octopuses
feel
pain
and
pleasure?
What
about
crabs,
shrimps,
insects,
or
spiders?
How
do
we
tell
whether
a
person
unresponsive
after
severe
brain
injury
might
be
suffering?
When
does
fetus
in
the
womb
start
to
have
conscious
experiences?
Could
there
even
rudimentary
feelings
miniature
models
of
human
brain,
grown
from
stem
cells?
And
what
AI?
These
are
questions
edge
sentience,
they
subject
enormous,
disorienting
uncertainty.
The
stakes
immense,
neglecting
risks
can
terrible
costs.
We
need
err
on
side
caution,
yet
it’s
often
far
clear
‘erring
caution’
should
mean
practice.
going
too
far?
not
doing
enough?
Edge
Sentience
presents
comprehensive
precautionary
framework
designed
help
us
reach
ethically
sound,
evidence-based
decisions
despite
our
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Март 12, 2024
The
zebrafish
(
Danio
rerio
)
is
increasingly
used
in
neuroscience
research.
Zebrafish
are
relatively
easy
to
maintain,
and
their
high
fecundity
makes
them
suitable
for
high-throughput
experiments.
Their
small,
transparent
embryos
larvae
allow
microscopic
imaging
of
the
developing
brain.
also
share
a
degree
genetic
similarity
with
humans,
amenable
manipulation
techniques,
such
as
gene
knockdown,
knockout,
or
knock-in,
which
allows
researchers
study
role
specific
genes
relevant
human
brain
development,
function,
disease.
can
serve
model
behavioral
studies,
including
locomotion,
learning,
social
interactions.
In
this
review,
we
present
state-of-the-art
methods
function
zebrafish,
tools
labeling
single
neurons
neuronal
circuits,
live
neural
activity,
synaptic
dynamics
protein
interactions
brain,
optogenetic
manipulation,
use
virtual
reality
technology
testing.
We
highlight
potential
research,
especially
regarding
genetic-based
disorders
discuss
its
certain
limitations
model.
Journal of Comparative Physiology A,
Год журнала:
2024,
Номер
210(2), С. 325 - 346
Опубликована: Фев. 27, 2024
Abstract
For
100
years,
the
Journal
of
Comparative
Physiology-A
has
significantly
supported
research
in
field
neuroethology.
The
celebration
journal’s
centennial
is
a
great
time
point
to
appreciate
recent
progress
neuroethology
and
discuss
possible
avenues
field.
Animal
behavior
main
source
inspiration
for
neuroethologists.
This
illustrated
by
huge
diversity
investigated
behaviors
species.
To
explain
at
mechanistic
level,
neuroethologists
combine
neuroscientific
approaches
with
sophisticated
behavioral
analysis.
rapid
technological
neuroscience
makes
highly
dynamic
exciting
research.
summarize
scientific
neuroethology,
I
went
through
all
abstracts
last
six
International
Congresses
Neuroethology
(ICNs
2010–2022)
categorized
them
based
on
sensory
modalities,
experimental
model
species,
topics.
highlights
gives
us
perspective
field’s
future.
At
end,
highlight
three
topics
that
may,
among
others,
influence
future
hope
sharing
my
roots
may
inspire
other
scientists
follow
neuroethological
approaches.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июнь 20, 2024
In
the
dynamic
landscape
of
biomedical
science,
pursuit
effective
treatments
for
motor
neuron
disorders
like
hereditary
spastic
paraplegia
(HSP),
amyotrophic
lateral
sclerosis
(ALS),
and
spinal
muscular
atrophy
(SMA)
remains
a
key
priority.
Central
to
this
endeavor
is
development
robust
animal
models,
with
zebrafish
emerging
as
prime
candidate.
Exhibiting
embryonic
transparency,
swift
life
cycle,
significant
genetic
neuroanatomical
congruencies
humans,
offer
substantial
potential
research.
Despite
difference
in
locomotion-zebrafish
undulate
while
humans
use
limbs,
presents
relevant
phenotypic
parallels
human
control
disorders,
providing
valuable
insights
into
neurodegenerative
diseases.
This
review
explores
zebrafish's
inherent
traits
how
they
facilitate
profound
complex
behavioral
cellular
phenotypes
associated
these
disorders.
Furthermore,
we
examine
recent
advancements
high-throughput
drug
screening
using
model,
promising
avenue
identifying
therapeutically
potent
compounds.
Development Growth & Differentiation,
Год журнала:
2023,
Номер
65(8), С. 453 - 458
Опубликована: Авг. 25, 2023
Autism
spectrum
disorder
(ASD)
is
one
of
the
most
common,
heritable
neuropsychiatric
disorders
in
world,
affecting
almost
1%
population.
The
core
symptoms
used
to
diagnose
ASD
are
decreased
social
interaction
and
increased
repetitive
behaviors.
Despite
large
number
affected
individuals,
precise
mechanisms
that
cause
this
remain
unclear.
identification
genes
environmental
factors
associated
with
allows
study
underlying
animal
models.
Although
presents
as
a
human
disorder,
based
on
recent
advances
understanding
their
brain
anatomy,
physiology,
behavior,
evolutionary
conservation
neuronal
cell
types,
I
propose
zebrafish
may
provide
novel
insights
into
etiology.
