Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in substantia nigra pars compacta. The precise etiology PD remains unclear, but emerging evidence suggests significant role for disrupted autophagy-a crucial cellular process maintaining protein and organelle integrity.

Язык: Английский

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Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

Seminars in Cancer Biology, Год журнала: 2023, Номер 92, С. 74 - 83

Опубликована: Апрель 11, 2023

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cells indefinitely perpetuate as well differentiate. stem cell populations within a growing tumor also help evade inhibitory effects chemo- radiation-therapies, in addition playing an important role metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with stemness, thus presenting attractive targets for therapy. The interest non-coding RNAs (ncRNAs) recent years has provided further insight into mechanisms by which TFs influence characteristics. There evidence direct regulation ncRNAs, such as, microRNAs (miRNAs), (lncRNAs) circular (circRNAs), vice versa. Additionally, TF-ncRNAs regulations often indirect, involving ncRNA-target genes or sponging other ncRNA species individual ncRNAs. information rapidly evolving this review provides comprehensive interactions implications on stemness response therapies. Such knowledge will uncover many levels tight control providing novel opportunities therapy process.

Язык: Английский

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Non-Coding RNAs in Parkinson's Disease: Regulating SNCA and Alpha-Synuclein Aggregation

Pathology - Research and Practice, Год журнала: 2024, Номер 261, С. 155511 - 155511

Опубликована: Июль 30, 2024

Язык: Английский

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The mechanistic view of non-coding RNAs as a regulator of inflammatory pathogenesis of Parkinson’s disease

Pathology - Research and Practice, Год журнала: 2024, Номер 258, С. 155349 - 155349

Опубликована: Май 16, 2024

Язык: Английский

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Protein-coding circular RNAs – mechanism, detection, and their role in cancer and neurodegenerative diseases

Biochemical and Biophysical Research Communications, Год журнала: 2023, Номер 678, С. 68 - 77

Опубликована: Авг. 18, 2023

Язык: Английский

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Exploring circular RNAs as biomarkers for Parkinson’s disease and their expression changes after aerobic exercise rehabilitation

Functional & Integrative Genomics, Год журнала: 2024, Номер 24(4)

Опубликована: Июль 29, 2024

Язык: Английский

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CIRCULAR RNAS: NEW AND EXCITING BIOMARKERS IN THE PROGNOSIS OF CARDIOVASCULAR DISEASES

Studies in Medical Sciences, Год журнала: 2024, Номер 35(7), С. 586 - 603

Опубликована: Окт. 1, 2024

Язык: Английский

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