IntechOpen eBooks,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 7, 2023
Since
the
study
of
neuroplastic
processes
brain,
it
was
understood
that
these
could
be
modulated
and
used
in
neurorehabilitation
patients
with
brain
damage.
The
optimal
method
neuromodulation
plasticity
is
noninvasive
transcranial
magnetic
stimulation
(TMS),
which
can
also
to
induce
nerve
impulses
parameters
we
need.
This
technique
allows
for
measuring
functional
state
central
nervous
system
(CNS)
using
neurophysiological
methods,
effectiveness
rehabilitation,
predicting
restoration
lost
functions.
We
measured
TMS
modulating
neuroplasticity
clinical-neurophysiological
data
scores
rating
scales
rehabilitation.
main
studies
were
provided
on
rehabilitation
stroke,
but
other
injuries.
Life Sciences,
Год журнала:
2024,
Номер
356, С. 123019 - 123019
Опубликована: Авг. 28, 2024
An
increase
in
life
expectancy
comes
with
a
higher
risk
for
age-related
neurological
and
cognitive
dysfunctions.
Given
the
psycho-socioeconomic
burden
due
to
unhealthy
aging
coming
decades,
United
Nations
has
declared
2021-2030
as
decade
of
healthy
aging.
In
this
line,
multipotent
mesenchymal
stromal
cell-based
therapeutics
received
special
interest
from
research
community.
Based
on
decades
cell
therapy,
consensus
emerged
that
therapeutic
effects
therapy
are
paracrine
mechanisms
rather
than
replacement.
Exosomes,
constituent
secretome,
nano-sized
vesicles
have
been
focus
intense
recent
years
possible
agent
or
cargo
deliver
drugs
into
central
nervous
system
induce
neurogenesis,
reduce
neuroinflammation,
confer
neuroregeneration/neuroprotection,
improve
motor
functions.
review,
we
discussed
neuroprotective
properties
exosomes
derived
adult
stem
cells,
role
exosomal
miRNAs.
We
also
reviewed
various
strategies
exosome
production
their
content
better
effects.
Further,
utilization
ectomesenchymal
cells
like
dental
pulp
treating
neurodegenerative
diseases.
Brain Sciences,
Год журнала:
2024,
Номер
14(11), С. 1092 - 1092
Опубликована: Окт. 30, 2024
In
the
past
five
years,
repetitive
transcranial
magnetic
stimulation
(rTMS)
has
evolved
significantly,
driven
by
advancements
in
device
design,
treatment
protocols,
software
integration,
and
brain-computer
interfaces
(BCIs).
This
review
evaluates
how
these
innovations
enhance
safety,
efficacy,
accessibility
of
rTMS
while
identifying
key
challenges
such
as
protocol
standardization
ethical
considerations.
A
structured
peer-reviewed
studies
from
2019
to
2024
focused
on
technological
clinical
rTMS,
including
AI-driven
personalized
treatments,
portable
devices,
integrated
BCIs.
AI
algorithms
have
optimized
patient-specific
devices
expanded
access.
Enhanced
coil
designs
BCI
integration
offer
more
precise
adaptive
neuromodulation.
However,
remain
standardizing
addressing
complexity,
ensuring
equitable
While
recent
improve
rTMS's
utility,
gaps
long-term
efficacy
concerns
persist.
Future
research
must
prioritize
standardization,
accessibility,
robust
frameworks
ensure
sustainable
impact.
BMJ Open,
Год журнала:
2025,
Номер
15(1), С. e086300 - e086300
Опубликована: Янв. 1, 2025
Introduction
Spasticity
is
a
common
complication
of
stroke,
which
related
to
poor
motor
recovery
and
limitations
in
the
performance
activities.
Both
transcranial
magnetic
stimulation
(TMS)
extracorporeal
shockwave
therapy
(ESWT)
are
effective
treatment
methods
for
poststroke
spasticity
(PSS).
However,
there
no
existing
study
exploring
safety
effectiveness
TMS
combined
with
ESWT
PSS.
Methods
analysis
This
will
be
prospective,
single-centre,
randomised,
factorial,
controlled
clinical
trial.
In
this
trial,
136
patients
PSS
randomly
divided
into
4
groups:
experimental
group
1
(TMS),
2
(ESWT),
3
(ESWT+TMS)
control
group,
34
each
group;
all
received
routine
rehabilitation.
Outcome
measures
assessed
by
time
points:
baseline
(T
0
),
weeks
after
initiation
)
follow-up
(4
end
treatment,
T
).
The
primary
outcome
modified
Ashworth
scale
at
.
secondary
outcomes
include
Tardieu
degree
spasticity,
Fugl-Meyer
assessment
range
motion
(ROM)
function,
stroke-specific
quality
life
(SS-QOL)
Barthel
index
activities
life,
cortical
excitability
measured
TMS–surface
electromyography
(EMG),
cerebral
cortex
oxygen
concentrations
functional
near-infrared
spectroscopy
(fNIRS)
H
max
/M
ratio
EMG.
Ethics
dissemination
protocol
was
approved
Committee
Army
Medical
Center
PLA
(Approval
No.
2024-04)
on
24
January
2024.
disseminated
through
peer-reviewed
publications
conference
presentations.
Trial
registration
number
registered
Chinese
Clinical
Registry
(
https://www.chictr.org.cn/
;
unique
identifier:
ChiCTR2400080862;
data:
9
February
2024;
V.
2.0).
The Egyptian Journal of Neurology Psychiatry and Neurosurgery,
Год журнала:
2025,
Номер
61(1)
Опубликована: Май 19, 2025
Abstract
Stroke
is
the
second
leading
cause
of
death
and
disability
globally.
However,
quality
life
rehabilitation
outcomes
stroke
survivors
are
greatly
impacted
by
non-motor
sequelae,
such
as
cognitive
impairment,
emotional
problems,
exhaustion,
sleep
abnormalities,
post-stroke
depression.
Post-stroke
therapy
often
neglects
common
problems
that
overlooked
in
treatment
process.
This
overview
provides
a
comprehensive
summary
current
therapeutic
therapies
for
focusing
on
both
pharmacological
non-pharmacological
approaches.
Pharmacological
interventions
symptoms,
cholinesterase
inhibitors,
psychostimulants,
antidepressants,
have
shown
varying
effectiveness.
In
addition
to
paralysis
motor
disability,
many
symptoms
related
involve
wide
range
manifestations
aphasia,
visual
hemineglect,
disorders,
depression,
all
which
significantly
impact
survivors.
Effective
management
these
crucial
promoting
successful
recovery
rehabilitation.
review
latest
evidence-based
addressing
optimize
recovery,
minimize
improve
patients.
Non-pharmacological
like
rehabilitation,
psychotherapy,
physical
exercise,
mindfulness-based
therapy,
neuromodulation
methods
transcranial
magnetic
stimulation
increasingly
recognized
their
complementary
benefits.
New
research
indicates
interdisciplinary
plans
most
effective
diverse
post-effects.
underscores
necessity
more
clinical
trials,
personalized
intervention
strategies,
standardized
evaluation
instruments
enhance
survivors'
overall
well-being.
Brain Sciences,
Год журнала:
2023,
Номер
13(12), С. 1662 - 1662
Опубликована: Ноя. 30, 2023
To
find
out
the
optimal
treatment
sessions
of
repetitive
transcranial
magnetic
stimulation
(TMS)
over
primary
motor
cortex
(M1)
for
upper
extremity
dysfunction
after
stroke
during
6-week
and
to
explore
its
mechanism
using
motor-evoked
potentials
(MEPs)
resting-state
functional
resonance
imaging
(rs-fMRI),
72
participants
with
ischemic
were
randomly
divided
into
control
group,
10-session,
20-session,
30-session
rTMS
groups.
Low-frequency
(1
Hz)
contralesional
M1
was
applied
in
all
The
function
assessed
before
treatment.
In
addition,
MEPs
rs-fMRI
data
analyzed
detect
effect
on
brain
reorganization.
After
6
weeks
treatment,
there
significant
differences
Fugl-Meyer
Assessment
Wolf
Motor
Function
Test
scores
between
10-session
group
20-
groups
while
no
difference
20-session
group.
Meanwhile,
found
decreased
excitability
corticospinal
tract
represented
by
amplitudes
enhanced
connectivity
ipsilesional
or
premotor
precentral
gyrus,
postcentral
cingulate
etc.
conclusion,
protocol
is
TMS
potential
related
influence
remodeling
corticomotor
networks.
Life,
Год журнала:
2024,
Номер
14(3), С. 329 - 329
Опубликована: Фев. 29, 2024
This
review
explores
the
pivotal
role
of
attention
in
everyday
life,
emphasizing
significance
studying
attention-related
brain
functions.
We
delve
into
development
methodologies
for
investigating
and
highlight
crucial
neuroimaging
transcranial
magnetic
stimulation
(TMS)
advancing
research.
Attention
optimization
theory
is
introduced
to
elucidate
neural
basis
attention,
identifying
key
regions
circuits
involved
processes.
The
further
neuroplasticity,
shedding
light
on
how
dynamically
adapts
changes
optimize
attention.
A
comprehensive
overview
TMS
provided,
elucidating
principles
applications
this
technique
affecting
activity
through
field
stimulation.
application
research
discussed,
outlining
it
can
be
employed
regulate
networks.
clinical
are
explored
attention-deficit/hyperactivity
disorder
(ADHD)
depression.
emerges
as
an
effective
treatment
ADHD,
showcasing
its
potential
addressing
disorders.
Additionally,
paper
emphasizes
efficacy
technology
a
method
regulating
depression,
underlining
versatility
therapeutic
settings.
In
conclusion,
underscores
interdisciplinary
approach
research,
integrating
neuroimaging,
TMS.
presented
findings
contribute
our
understanding
mechanisms
promising
synthesis
theoretical
practical
insights
aims
propel
advancements
applications.
Journal of Neurophysiology,
Год журнала:
2024,
Номер
132(4), С. 1211 - 1222
Опубликована: Авг. 28, 2024
Spinal
cord
injury
is
a
serious
disabling
central
nervous
system
disease.
Recently,
research
on
magnetic
stimulation
therapy
for
spinal
has
been
increasing,
and
its
potential
gradually
attracted
the
attention
of
experts.
This
study
found
that
repetitive
(rMS)
can
improve
motor
function
reduce
neuronal
apoptosis
in
rats.
The
mechanism
may
be
related
to
increasing
expression
phosphatidylinositol-3
kinase
(PI3K)/Akt
protein,
thereby
inhibiting
cell
promoting
survival.
