Life,
Год журнала:
2025,
Номер
15(6), С. 834 - 834
Опубликована: Май 22, 2025
Specific
gut
microorganisms
and
their
metabolic
by-products
have
been
identified
as
key
regulators
of
host
physiology,
contributing
to
the
modulation
immune
system,
inflammatory
processes,
brain
function,
behavior,
which
highlights
microbiome
a
potential
modulator
neurobiological
mechanisms
involved
in
substance
use
disorders.
This
narrative
review
provides
an
updated
overview
how
drugs
abuse
influence
composition
dynamics
human
bacterial
dysbiosis
may
be
factor
disorders
by
modulating
communication
between
brain.
Thus,
examining
commonly
abused
substances
such
alcohol,
psychostimulants,
opioids,
cannabinoids,
nicotine,
this
aimed
deepen
understanding
bidirectional
relationship
use.
There
is
evidence
indicating
that
alterations
addiction
through
changes
gut-brain
signaling.
Furthermore,
its
metabolites
not
only
result
from
disorders,
but
could
also
modulate
behavioral
responses
abuse.
Although
exact
modulates
are
fully
understood,
microbial
products
short-chain
fatty
acids,
tryptophan
metabolites,
bile
neurotransmitters
suggested
play
role
process
influencing
blood–brain
barrier
permeability,
activation,
neural
signaling,
gene
expression.
Therefore,
manipulating
or
represent
promising
approach
for
enhancing
disorder
treatments,
identifying
individuals
at
increased
risk
pathological
drug
use,
elucidating
substance-related
behaviors.
Pathogens,
Год журнала:
2024,
Номер
13(4), С. 276 - 276
Опубликована: Март 24, 2024
Staphylococcus
aureus
(S.
aureus)
is
a
common
pathogen
that
can
cause
many
human
diseases,
such
as
skin
infection,
food
poisoning,
endocarditis,
and
sepsis.
These
diseases
be
minor
infections
or
life-threatening,
requiring
complex
medical
management
resulting
in
substantial
healthcare
costs.
Meanwhile,
the
critically
ignored
“organ,”
intestinal
microbiome
greatly
impacts
physiological
health,
not
only
gastrointestinal
but
also
disorders
beyond
gut.
However,
correlation
between
S.
infection
microbial
homeostasis
largely
unknown.
Here,
we
summarized
recent
progress
understanding
their
interactions
with
intestine.
summarizations
will
help
us
understand
mechanisms
behind
these
crosstalk
challenges
are
facing
now,
which
could
contribute
to
preventing
infections,
effective
treatment
investigation,
vaccine
development.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3198 - 3198
Опубликована: Март 11, 2024
Multiple
sclerosis
(MS)
is
a
chronic
inflammatory
and
neurodegenerative
central
nervous
system
(CNS)
disorder,
characterized
by
focal
inflammation,
demyelination,
irreversible
axonal
loss
neurodegeneration.
The
proposed
mechanism
involves
auto-reactive
T
lymphocytes
crossing
the
blood–brain
barrier
(BBB),
contributing
to
inflammation
demyelination.
Pro-inflammatory
Th1
Th17
are
pivotal
in
MS
pathogenesis,
highlighting
an
imbalanced
interaction
with
regulatory
cells.
Dysbiosis
gut
microbiota,
microbial
imbalance
implicated
systemic
yet
its
exact
role
remains
elusive.
Short-chain
fatty
acids
(SCFAs),
including
valerate,
butyrate,
propionate,
acetate,
produced
through
dietary
fiber
fermentation
modulate
immune
responses.
Particularly,
butyrate
propionate
exhibit
pronounced
anti-inflammatory
effects
both
CNS.
These
SCFAs
influence
lymphocyte
expression
BBB
permeability.
This
review
discusses
potential
therapeutic
implications
of
SCFA
MS,
their
ability
gut–brain
axis
restore
balance.
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 793 - 793
Опубликована: Фев. 25, 2025
The
growing
global
focus
on
the
adverse
health
conditions
associated
with
excessive
sugar
consumption
has
prompted
and
policy
organizations
as
well
public
to
take
a
more
mindful
approach
wellness.
In
response,
food
beverage
companies
have
proactively
innovated
reformulated
their
product
portfolios
incorporate
low
no-calorie
sweeteners
(LNCSs)
viable
alternatives
sugar.
LNCSs
offer
an
effective
safe
delivering
sweetness
foods
beverages
reducing
calories
intake
while
contributing
enjoyment
of
eating.
objective
this
paper
is
enhance
understanding
segmentation
definitions,
dietary
reduction
guidance,
front-of-package
labeling,
taste
sensory
perception
physiology,
metabolic
efficacy
impact,
overall
safety
Foods,
Год журнала:
2025,
Номер
14(9), С. 1559 - 1559
Опубликована: Апрель 29, 2025
Neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
the
most
common
form
of
dementia,
represent
a
growing
global
health
crisis,
yet
current
treatment
strategies
remain
primarily
palliative.
Recent
studies
have
shown
that
neurodegeneration
through
complex
interactions
within
gut-brain
axis
largely
depends
on
gut
microbiota
and
its
metabolites.
This
review
explores
intricate
molecular
mechanisms
linking
dysbiosis
to
cognitive
decline,
emphasizing
impact
microbial
metabolites,
including
short-chain
fatty
acids
(SCFAs),
bile
acids,
tryptophan
neuroinflammation,
blood-brain
barrier
(BBB)
integrity,
amyloid-β
tau
pathology.
The
paper
highlights
major
microbiome
signatures
associated
with
disease,
detailing
their
metabolic
pathways
inflammatory
crosstalk.
Dietary
interventions
promise
in
modulating
composition,
potentially
mitigating
neurodegenerative
processes.
critically
examines
influence
dietary
patterns,
Mediterranean
Western
diets,
microbiota-mediated
neuroprotection.
Bioactive
compounds
like
prebiotics,
omega-3
polyphenols
exhibit
neuroprotective
effects
by
reducing
neuroinflammation.
Furthermore,
it
discusses
emerging
microbiome-based
therapeutic
strategies,
probiotics,
postbiotics,
fecal
transplantation
(FMT),
potential
for
slowing
progression.
Despite
these
advances,
several
knowledge
gaps
remain,
interindividual
variability
responses
need
large-scale,
longitudinal
studies.
study
proposes
an
integrative,
precision
medicine
approach,
incorporating
science
into
paradigms.
Ultimately,
cognizance
at
mechanistic
level
could
unlock
novel
avenues,
offering
non-invasive,
diet-based
strategy
managing
improving
health.
Deleted Journal,
Год журнала:
2025,
Номер
70(1), С. 5 - 5
Опубликована: Фев. 5, 2025
The
rising
global
prevalence
of
obesity
and
its
associated
metabolic
disorders
highlights
the
urgent
need
for
innovative,
sustainable
interventions.
Probiotics,
as
modulators
gut
microbiota,
have
emerged
promising
agents
in
weight
management
by
influencing
health.
This
mini-review
explores
role
probiotics
modulating
microbiota
to
support
energy
metabolism,
appetite
regulation,
fat
storage.
Evidence
underscores
strain-specific
benefits
probiotics,
such
Lactobacillus
gasseri
SBT2055,
Bifidobacterium
breve
B-3,
Akkermansia
muciniphila,
reducing
visceral
fat,
improving
glucose
mitigating
obesity-related
inflammation.
mechanisms
underlying
these
effects
include
short-chain
fatty
acid
(SCFA)
production,
modulation
appetite-regulating
hormones,
improvements
barrier
integrity.
While
findings
are
promising,
variability
outcomes
importance
tailored
probiotic
interventions
standardized
methodologies
future
research.
By
addressing
challenges,
can
serve
integral
components
personalized
nutrition
strategies,
advancing
both
health
public
objectives.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
The
infant
gut
microbiota
undergoes
significant
changes
during
early
life,
which
are
essential
for
immune
system
maturation,
nutrient
absorption,
and
metabolic
programming.
Among
the
various
microbial
metabolites,
short-chain
fatty
acids
(SCFAs),
primarily
acetate,
propionate,
butyrate,
produced
through
fermentation
of
dietary
fibers
by
bacteria,
have
emerged
as
critical
modulators
host-microbiota
interactions.
SCFAs
serve
energy
sources
colonic
cells
play
pivotal
roles
in
regulating
responses,
maintaining
barrier
integrity,
influencing
systemic
pathways.
Recent
research
highlights
potential
neuroprotective
effects
pediatric
populations.
Disruptions
composition
SCFA
production
increasingly
associated
with
a
range
health
issues,
including
obesity,
allergic
disorders,
inflammatory
bowel
disease
(IBD),
neurodevelopmental
disorders.
This
review
synthesizes
current
knowledge
on
role
microbiota-derived
health,
emphasizing
their
contributions
from
development
to
neuroprotection.
It
also
underscores
need
further
unravel
precise
mechanisms
influence
develop
targeted
interventions
that
leverage
therapeutic
benefits.
Journal of Food Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Abstract
Sleep
disturbances
are
increasingly
prevalent,
significantly
impacting
physical
and
mental
health.
Recent
research
reveals
a
bidirectional
relationship
between
gut
microbiota
sleep,
mediated
through
the
microbiota–gut–brain
axis.
This
review
examines
role
of
in
sleep
physiology
explores
how
biotics,
including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fermented
foods,
can
enhance
quality.
Drawing
from
animal
human
studies,
we
discuss
neurobiological
mechanisms
by
which
biotics
may
influence
modulation
neurotransmitters,
immune
responses,
hormonal
regulation.
Key
microbial
metabolites,
such
as
short‐chain
fatty
acids,
highlighted
for
their
supporting
sleep‐related
neurochemical
processes.
Additionally,
this
presents
dietary
strategies
food
processing
technologies,
like
fermentation,
innovative
approaches
enhancement.
Although
promising,
available
has
limitations,
small
sample
sizes,
variability
biotic
strains
dosages,
reliance
on
subjective
assessments.
underscores
need
standardized
protocols,
objective
assessments
polysomnography,
personalized
interventions.
Emerging
findings
highlight
therapeutic
potential
improvement,
though
further
large‐scale
trials
essential
to
refine
strain
selection,
dosage,
formulation.
interdisciplinary
exploration
seeks
advance
food‐based
interventions
holistic
managing
disorders
improving
quality
life.
