Life,
Год журнала:
2025,
Номер
15(6), С. 834 - 834
Опубликована: Май 22, 2025
Specific
gut
microorganisms
and
their
metabolic
by-products
have
been
identified
as
key
regulators
of
host
physiology,
contributing
to
the
modulation
immune
system,
inflammatory
processes,
brain
function,
behavior,
which
highlights
microbiome
a
potential
modulator
neurobiological
mechanisms
involved
in
substance
use
disorders.
This
narrative
review
provides
an
updated
overview
how
drugs
abuse
influence
composition
dynamics
human
bacterial
dysbiosis
may
be
factor
disorders
by
modulating
communication
between
brain.
Thus,
examining
commonly
abused
substances
such
alcohol,
psychostimulants,
opioids,
cannabinoids,
nicotine,
this
aimed
deepen
understanding
bidirectional
relationship
use.
There
is
evidence
indicating
that
alterations
addiction
through
changes
gut-brain
signaling.
Furthermore,
its
metabolites
not
only
result
from
disorders,
but
could
also
modulate
behavioral
responses
abuse.
Although
exact
modulates
are
fully
understood,
microbial
products
short-chain
fatty
acids,
tryptophan
metabolites,
bile
neurotransmitters
suggested
play
role
process
influencing
blood–brain
barrier
permeability,
activation,
neural
signaling,
gene
expression.
Therefore,
manipulating
or
represent
promising
approach
for
enhancing
disorder
treatments,
identifying
individuals
at
increased
risk
pathological
drug
use,
elucidating
substance-related
behaviors.
Veterinary Sciences,
Год журнала:
2025,
Номер
12(5), С. 412 - 412
Опубликована: Апрель 27, 2025
Stress
in
dog
breeding
leads
to
significant
physiological
and
psychological
burdens,
including
anxiety,
reduced
appetite,
weakened
immune
function,
gut
microbiota
imbalance,
even
death.
Currently,
there
are
various
pharmacological
interventions
for
stress
management,
but
few
focus
on
health.
This
study
evaluates
the
potential
of
a
novel
strain,
Enterococcus
faecium
Kimate-X,
alleviating
transport
improving
health
dogs,
providing
an
alternative
traditional
treatments.
In
vitro
experiments
showed
that
Kimate-X
significantly
enhanced
activities
superoxide
dismutase
(SOD)
catalase
(CAT)
while
reducing
levels
malondialdehyde
(MDA)
tumor
necrosis
factor-α
(TNF-α)
RAW
264.7
macrophage
cells.
vivo,
dogs
supplemented
with
exhibited
lower
cortisol
after
transport,
indicating
stress.
Metagenomic
analysis
revealed
increased
diversity
higher
concentrations
short-chain
fatty
acids
(acetate,
propionate,
butyrate)
fecal
samples.
systematically
uncovers
mechanism
by
which
alleviates
through
modulation
microbiota.
These
findings
provide
new
scientific
evidence
supporting
use
probiotics
as
approach
management
animals.
Life,
Год журнала:
2025,
Номер
15(6), С. 834 - 834
Опубликована: Май 22, 2025
Specific
gut
microorganisms
and
their
metabolic
by-products
have
been
identified
as
key
regulators
of
host
physiology,
contributing
to
the
modulation
immune
system,
inflammatory
processes,
brain
function,
behavior,
which
highlights
microbiome
a
potential
modulator
neurobiological
mechanisms
involved
in
substance
use
disorders.
This
narrative
review
provides
an
updated
overview
how
drugs
abuse
influence
composition
dynamics
human
bacterial
dysbiosis
may
be
factor
disorders
by
modulating
communication
between
brain.
Thus,
examining
commonly
abused
substances
such
alcohol,
psychostimulants,
opioids,
cannabinoids,
nicotine,
this
aimed
deepen
understanding
bidirectional
relationship
use.
There
is
evidence
indicating
that
alterations
addiction
through
changes
gut-brain
signaling.
Furthermore,
its
metabolites
not
only
result
from
disorders,
but
could
also
modulate
behavioral
responses
abuse.
Although
exact
modulates
are
fully
understood,
microbial
products
short-chain
fatty
acids,
tryptophan
metabolites,
bile
neurotransmitters
suggested
play
role
process
influencing
blood–brain
barrier
permeability,
activation,
neural
signaling,
gene
expression.
Therefore,
manipulating
or
represent
promising
approach
for
enhancing
disorder
treatments,
identifying
individuals
at
increased
risk
pathological
drug
use,
elucidating
substance-related
behaviors.
