Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome DOI Open Access

K. Wirth,

Matthias Löhn

Опубликована: Дек. 13, 2023

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There broad overlap in the symptomatology of ME/CFS Post-COVID (PCS). A fraction PCS patients develops full clinical picture ME/CFS. New observations microvessels blood from suffering have appeared include microclots malformed pathological cells. Capillary flow impaired not only by components but also prothrombotic changes vascular wall, endothelial dysfunction, expression adhesion molecules capillaries. These disturbances can finally cause low capillary even stasis. cardiac stroke volume due to hypovolemia inability capacitance vessels adequately constrict deliver necessary preload generate an unfavorable precapillary perfusion pressure. Furthermore, predominance vasoconstrictor over vasodilator influences exists, which sympathetic hyperactivity dysfunction play strong role, causing constriction resistance sphincters leads fall pressure behind sphincters. The interaction these two cardiovascular mechanisms hemodynamically highly presence primary stasis already caused their with severely impair organ perfusion. detrimental coincidence microcirculatory may constitute key disturbance Post-COVID-19 syndrome lead pre-disposed because causes particular kind - ischemia-reperfusion has high potential mitochondrial inducing sodium- calcium-overload skeletal muscles. latter turns worsens situation generation reactive oxygen species close vicious cycle patient hardly escape.

Язык: Английский

Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study DOI Creative Commons
Suzanne D. Vernon, Tianyu Zheng, Hyungrok Do

и другие.

Journal of General Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS SARS-CoV-2 infection is unknown. Objective To determine the incidence and prevalence of post-COVID-19 among adults enrolled in Researching COVID to Enhance Recovery (RECOVER-Adult) study. Design, Setting, Participants RECOVER-Adult a longitudinal observational cohort study conducted across U.S. We included participants who had visit at least 6 months no pre-existing ME/CFS, grouped as (1) acute infected, within 30 days or uninfected became infected ( n =4515); (2) post-acute greater than =7270); (3) (1439). Measurements Incidence rate based on 2015 Institute Medicine clinical diagnostic criteria. Results The followed from time was 2.66 (95% CI 2.63–2.70) per 100 person-years while matched 0.93 0.91–10.95) person-years: hazard ratio 4.93 3.62–6.71). proportion all that met criteria for following 4.5% (531 11,785) compared 0.6% (9 1439) participants. Post-exertional malaise most common symptom (24.0%, 2830 11,785). Most with also RECOVER long (88.7%, 471 531). Limitations uses self-reported symptoms. Symptoms can wax wane. Conclusion diagnosable sequela develops an increased provides unprecedented opportunity ME/CFS.

Язык: Английский

Процитировано

4
Cardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study DOI Creative Commons
Lauren E. Oberlin, Lu Wan, Chaeryon Kang

и другие.

British Journal of Sports Medicine, Год журнала: 2024, Номер unknown, С. bjsports - 108257

Опубликована: Дек. 10, 2024

To evaluate the association between cardiorespiratory fitness (CRF) and cognition in a large sample of older adults, to examine clinical demographic factors that might moderate these associations.

Язык: Английский

Процитировано

6
Cognitive Impairments in Two Samples of Individuals with ME/CFS and Long COVID: A Comparative Analysis DOI

Zoe Sirotiak,

Jenna L. Adamowicz, Emily B.K. Thomas

и другие.

Journal of Clinical Psychology in Medical Settings, Год журнала: 2025, Номер unknown

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

0
Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evolving from the Post COVID-19 Syndrome DOI Creative Commons

K. Wirth,

Matthias Löhn

Medicina, Год журнала: 2024, Номер 60(2), С. 194 - 194

Опубликована: Янв. 23, 2024

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There broad overlap in the symptomatology of ME/CFS Post-COVID-19 (PCS). A fraction PCS patients develop full clinical picture ME/CFS. New observations microvessels blood from suffering have appeared include microclots malformed pathological cells. Capillary flow impaired not only by components but also prothrombotic changes vascular wall, endothelial dysfunction, expression adhesion molecules capillaries. These disturbances can finally cause low capillary even stasis. cardiac stroke volume due to hypovolemia inability capacitance vessels adequately constrict deliver necessary preload generate an unfavorable precapillary perfusion pressure. Furthermore, predominance vasoconstrictor over vasodilator influences exists, which sympathetic hyperactivity dysfunction play strong role, causing constriction resistance sphincters, leads fall pressure behind sphincters. The interaction these two cardiovascular mechanisms hemodynamically highly presence primary stasis, already caused their with severely impair organ perfusion. detrimental coincidence microcirculatory may constitute key disturbance syndrome lead predisposed because causes particular kind disturbance—capillary ischemia/reperfusion—which has high potential mitochondrial inducing sodium- calcium-overload skeletal muscles. latter, turn, worsens situation through generation reactive oxygen species close vicious cycle patient hardly escape.

Язык: Английский

Процитировано

2
More than “Brain Fog”: Cognitive Dysfunction and the Role of Occupational Therapy in Long COVID DOI

Helen Skiffington,

Ciara Breen

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер 36(1), С. 39 - 49

Опубликована: Дек. 30, 2024

Long COVID is a disabling condition which affects occupational performance and quality of life. It interferes with activities daily living, work, many meaningful life roles. Cognitive dysfunction frequently reported symptom, yet it commonly overlooked. important that cognitive activity considered when working people long COVID, particularly identifying triggers post exertional symptom exacerbation. There are potential mechanisms could be driving in including neuroinflammation, viral persistence, vascular damage, orthostatic intolerance. to consider these help guide intervention. The purpose this clinical perspective highlight the debilitating impact those share key role therapists area. may missed on standardized assessments as they not sensitive enough due episodic nature symptoms. Occupational can play area experts assessing providing safe assessment rehabilitation.

Язык: Английский

Процитировано

2
Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome DOI Open Access

K. Wirth,

Matthias Löhn

Опубликована: Дек. 13, 2023

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There broad overlap in the symptomatology of ME/CFS Post-COVID (PCS). A fraction PCS patients develops full clinical picture ME/CFS. New observations microvessels blood from suffering have appeared include microclots malformed pathological cells. Capillary flow impaired not only by components but also prothrombotic changes vascular wall, endothelial dysfunction, expression adhesion molecules capillaries. These disturbances can finally cause low capillary even stasis. cardiac stroke volume due to hypovolemia inability capacitance vessels adequately constrict deliver necessary preload generate an unfavorable precapillary perfusion pressure. Furthermore, predominance vasoconstrictor over vasodilator influences exists, which sympathetic hyperactivity dysfunction play strong role, causing constriction resistance sphincters leads fall pressure behind sphincters. The interaction these two cardiovascular mechanisms hemodynamically highly presence primary stasis already caused their with severely impair organ perfusion. detrimental coincidence microcirculatory may constitute key disturbance Post-COVID-19 syndrome lead pre-disposed because causes particular kind - ischemia-reperfusion has high potential mitochondrial inducing sodium- calcium-overload skeletal muscles. latter turns worsens situation generation reactive oxygen species close vicious cycle patient hardly escape.

Язык: Английский

Процитировано

1