Scientists
are
increasingly
proposing
measures
of
retinal
neurochemistry
as
biomarkers
clinical
conditions,
including
autism,
attention-deficit/hyperactivity
disorder
and
schizophrenia.Frontiers
in
Neuroscience
Autistic
children
have
lower
blood
levels
the
protein
ADAM8
than
non-autistic
do,
according
to
a
small
study.Neuropsychiatric
Disease
Treatment
toddlers
show
altered
neural
responses
human
speech.Journal
Online
surveys
susceptible
fraudulent
responses,
but
there
ways
identify
prevent
such
fakes.Spectrum
reported
on
various
efforts
flag
online
survey
fraud
last
week.PLOS
Global
Public
Health
people
better
at
interpreting
behavior
an
autistic
person
workplace
setting.Autism
Adulthood
The
National
Association
for
Biomedical
Research
is
challenging
conservation
group's
determination
that
long-tailed
macaques,
primate
commonly
used
research,
endangered.Science
Variants
genes
-such
SCN1A
KCNA1
-that
affect
ion
channels
cause
epilepsy
appear
bring
about
metabolic
changes
contribute
seizure
activity,
review.Journal
Neurochemistry
Non-cancer
therapies
genetic
conditions
take
average
25
years
develop
-from
identification
target
government
approval
treatment.Nature
Frequency
change:
(top
row)
(bottom
different
EEG
activity
response
natural
speech.
Sensors,
Год журнала:
2023,
Номер
23(21), С. 8727 - 8727
Опубликована: Окт. 26, 2023
The
electroretinogram
(ERG)
is
a
clinical
test
that
records
the
retina's
electrical
response
to
light.
Analysis
of
ERG
signal
offers
promising
way
study
different
retinal
diseases
and
disorders.
Machine
learning-based
methods
are
expected
play
pivotal
role
in
achieving
goals
diagnostics
treatment
control.
This
aims
improve
classification
accuracy
previous
work
using
combination
three
optimal
mother
wavelet
functions.
We
apply
Continuous
Wavelet
Transform
(CWT)
on
dataset
mixed
pediatric
adult
signals
show
possibility
simultaneous
analysis
signals.
modern
Visual
Transformer-based
architectures
tested
time-frequency
representation
method
provides
88%
for
Maximum
2.0
ERG,
85%
Scotopic
2.0,
91%
Photopic
protocols,
which
average
improves
result
by
7.6%
compared
work.
BMC Research Notes,
Год журнала:
2023,
Номер
16(1)
Опубликована: Сен. 29, 2023
The
electroretinogram
is
a
clinical
test
commonly
used
in
the
diagnosis
of
retinal
disorders
with
peak
time
and
amplitude
a-
b-waves
as
main
indicators
function.
However,
subtle
changes
that
affect
shape
waveform
may
occur
early
stages
disease
or
conditions
have
neurodevelopmental
neurodegenerative
origin.
In
such
cases,
we
introduce
statistical
approach
to
mathematically
model
aid
clinicians
researchers
using
other
biological
signal
recordings
identify
morphological
features
waveforms
not
be
captured
by
time-frequency
domains
waveforms.
We
present
graphics-based
analysis
ascending
limb
b-wave
(AL-b)
children
without
autism
spectrum
disorder
(ASD)
narrative
explanation
illustrate
how
different
based
on
location
scale
derived
from
raw
registered
series
can
reveal
differences
between
groups.Analysis
trajectories
confirmed
findings
previous
studies
reduced
delayed
ASD.
when
individual
were
then
group
visible
mean
at
~
0.6
suggesting
novel
method
differentiate
groups
registration
ERG
waveform.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
164, С. 105833 - 105833
Опубликована: Июль 30, 2024
Major
Depressive
Disorder
(MDD)
is
characterized
by
at
least
one
major
depressive
episode.
It
requires
medical
attention
typically
involving
the
prescription
of
antidepressants.
Remission
in
MDD
patients
often
difficult
to
achieve
because
limited
effectiveness
these
drugs.
Nowadays,
numerous
undergo
various
antidepressant
treatments,
with
subjective
changes
their
personal
experiences
being
regularly
monitored.
Therefore,
it
essential
find
clinical
and
objective
tools
that
offer
a
more
tailored
approach
selection.
The
neurochemistry
retina
similar
brain,
promising
would
be
use
ElectroRetinoGraphy
(ERG)
measurements
on
requiring
treatment.
Thus,
aim
this
scoping
review
highlight
effects
different
classes
antidepressants
retinal
function
evaluated
full-field
ERG
(ffERG),
Pattern
(PERG)
multifocal
(mfERG)
waveforms
patients.
These
could
serve
as
pivotal
indicators
defining
patient
profiles,
facilitating
personalized
therapeutic
interventions,
thereby
advancing
precision
psychiatry.
Biomarkers in Neuropsychiatry,
Год журнала:
2024,
Номер
10, С. 100095 - 100095
Опубликована: Апрель 30, 2024
Exposure
to
childhood
trauma
may
cause
several
alterations
in
brain
structure
and
connectivity
adult
patients
having
a
major
psychiatric
disorder.
Recent
reports
have
shown
that
young
healthy
offspring
of
carry
similar
abnormal
retinal
response.
Because
the
retina
same
embryonic
origin,
gives
access
living
neuronal
tissue
capture
early
neurobiological
effect
trauma.
Evaluate
association
between
exposure
anomalies
cone
(photopic)
rod
(scotopic)
responses
assessed
by
electroretinography
(ERG)
children
adolescents
at
familial
risk
(FHRs)
psychosis
or
mood
disorders.
ERG
recordings
(n=194)
undertaken
on
134
(Mage
1st
recording=15.7,
49%
females)
enrolled
our
longitudinal
study
born
parent
DSM-IV
schizophrenia,
bipolar
disorder
depressive
were
analyzed
using
repeated
measures
linear
mixed
models
applying
multiple
comparisons.
The
scotopic
photopic
a-
b-wave
latencies
amplitudes
recorded.
Five
types
prospectively
retrospectively
FHRs:
physical
abuse,
sexual
emotional
neglect
witnessing
domestic
violence.
None
parameters
associated
with
global
measure
However,
when
analyzing
specific
each
type
trauma,
data
suggested
abuse
girls
would
be
significantly
prolonged
a-wave
latency
(p=0.024,
ES=0.28)
trend
was
observed
(p=0.099,
ES=0.27).
Our
did
not
suggest
substantial
previously
reported
response
youth
Only
one
i.e.,
violence
toward
child,
could
girls.
Methodological
limitations
are
discussed
for
consideration
interpreting
findings.
Autism Research,
Год журнала:
2024,
Номер
17(8), С. 1520 - 1533
Опубликована: Июль 29, 2024
Abstract
Autism
spectrum
disorder
(ASD)
is
a
widely
recognized
neurodevelopmental
disorder,
yet
the
identification
of
reliable
imaging
biomarkers
for
its
early
diagnosis
remains
challenge.
Considering
specific
manifestations
ASD
in
eyes
and
interconnectivity
between
brain
eyes,
this
study
investigates
through
lens
retinal
analysis.
We
specifically
examined
differences
macular
region
retina
using
optical
coherence
tomography
(OCT)/optical
angiography
(OCTA)
images
children
diagnosed
with
those
typical
development
(TD).
Our
findings
present
potential
novel
characteristics
ASD:
thickness
ellipsoid
zone
(EZ)
cone
photoreceptors
was
significantly
increased
ASD;
large‐caliber
arteriovenous
inner
reduced
these
changes
EZ
were
more
significant
left
eye
than
right
eye.
These
observations
photoreceptor
alterations,
vascular
function
changes,
lateralization
phenomena
warrant
further
investigation,
we
hope
that
work
can
advance
interdisciplinary
understanding
ASD.
