Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Nutrients, Год журнала: 2024, Номер 16(6), С. 789 - 789

Опубликована: Март 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Язык: Английский

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Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Янв. 29, 2024

Emerging evidence indicates that antibiotic-induced dysbiosis can play an etiological role in the pathogenesis of neuropsychiatric disorders. However, most this comes from rodent models. The objective study was to evaluate if gut elicit changes metabolites and behavior indicative gut-brain axis disruption common marmosets (Callithrix jacchus) – a nonhuman primate model often used sociability stress. We were able successfully induce using custom antibiotic cocktail (vancomycin, enrofloxacin neomycin) administered orally for 28 days. This altered metabolite profiles, behavior, stress reactivity. Increase Fusobacterium spp. post-antibiotic administration novel dysbiotic response has not been observed any or human studies date. There significant concentrations several which are either neurotransmitters (e.g., GABA serotonin) have found be moderators communication models short-chain fatty acids bile acids). increase affiliative antibiotic-administered marmosets, might coping mechanism dysbiosis-induced urinary cortisol levels after multiple stressors provides more definitive proof may cause disrupted between brain marmosets. is first attempt establish as impact severe on cross-talk behavior.

Язык: Английский

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ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Язык: Английский

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Agmatine modulation of gut-brain axis alleviates dysbiosis-induced depression-like behavior in rats

European Journal of Pharmacology, Год журнала: 2024, Номер 981, С. 176884 - 176884

Опубликована: Авг. 10, 2024

Язык: Английский

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The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research

Biomolecules, Год журнала: 2024, Номер 14(8), С. 1017 - 1017

Опубликована: Авг. 16, 2024

Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.

Язык: Английский

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Supplementation with Lactobacillus helveticus NS8 alleviated behavioral, neural, endocrine, and microbiota abnormalities in an endogenous rat model of depression

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

Major depressive disorder is a condition involving microbiota-gut-brain axis dysfunction. Increasing research aims to improve depression through gut microbiota regulation, including interventions such as probiotics, prebiotics, and fecal transplants. However, most focuses on exogenous induced by chronic stress or drugs, with less attention given endogenous depression. Additionally, mycobiota in significantly than that bacteria.

Язык: Английский

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Disruption of collective behaviour correlates with reduced interaction efficiency

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 292(2043)

Опубликована: Март 1, 2025

Group-living organisms commonly engage in collective behaviour to respond an ever-changing environment. As animals face environmental change, establishing the mechanisms of information used collectively behave is critical. Western honeybees ( Apis mellifera ) are highly social insects that tightly coordinate many individuals ensure optimum colony function. We fanning, a thermoregulatory depends on both and thermal contexts, as case study for behaviour. To identify potential behind coordination we oxytetracycline, antibiotic apiculture known pollutant impairs bee physiology Specifically, hypothesized interactions drive fanning response predicted oxytetracycline would disrupt which will lead reduced response. found longer exposure antibiotics decreases fanning. Using automated tracking, show treatment reduces number interactions, impeding dynamics within these small groups. Our results contribute strong evidence between may honeybees. This work emphasizes importance understanding underlie animal how effects pollutants individual can scale affect populations.

Язык: Английский

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Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract The current discovery that the gut microbiome, which contains roughly 100 trillion microbes, affects health and disease has catalyzed a boom in multidisciplinary research efforts focused on understanding this relationship. Also, it is commonly demonstrated CNS are closely related bidirectional pathway. A balanced microbiome essential for regular brain activities emotional responses. On other hand, regulates majority of GI physiology. Any disruption pathway led to progression problems both directions, neurological gastrointestinal diseases. In review, we hope shed light complicated connections microbiome-gut-brain axis critical roles early development order get deeper knowledge microbiome-mediated pathological conditions management options through rebalancing microbiome.

Язык: Английский

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The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)

Immune Network, Год журнала: 2024, Номер 24(3)

Опубликована: Янв. 1, 2024

The brain and lungs, vital organs in the body, play essential roles maintaining overall well-being survival. These interact through complex sophisticated bi-directional pathways known as 'lung-brain axis', facilitated by their close proximity neural connections. Numerous studies have underscored mediation of lung-brain axis inflammatory responses hypoxia-induced damage, which are pivotal to progression both pulmonary neurological diseases. This review aims delve into how diseases, including acute/chronic airway diseases conditions, can instigate disorders such stroke, Alzheimer's disease, Parkinson's disease. Additionally, we highlight emerging research on lung microbiome which, drawing parallels between gut lungs terms contents, may a significant role modulating health. Ultimately, this paves way for exciting avenues future therapeutics addressing respiratory

Язык: Английский

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Gut dysbiosis mediates the association between antibiotic exposure and chronic disease

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 6, 2024

Antibiotics are safe, effective drugs and continue to save millions of lives prevent long-term illness worldwide. A large body epidemiological, interventional experimental evidence shows that exposure antibiotics has negative effects on human health. We reviewed the literature data links between antibiotic exposure, gut dysbiosis, chronic disease (notably with regard “developmental origins health disease” (“DOHaD”) approach). Molecular biology studies show systemic administration infants a rapid onset but also often long-lasting impact microbial composition gut. Along other environmental factors (e.g., an unhealthy “Western” diet sedentary behavior), induce which can be defined as disruption previously stable, functionally complete microbiota. Gut dysbiosis many harmful Associations early-life have been reported for diseases, including inflammatory bowel disease, celiac some cancers, metabolic diseases (obesity type 2 diabetes), allergic autoimmune disorders, atherosclerosis, arthritis, neurodevelopmental, neurodegenerative neurological diseases. In mechanistic terms, influences through direct mucosal immune pathways, plus wide array or indirect short-chain fatty acids, enteric nervous system, peristaltic motility, production hormones neurotransmitters, loss intestinal barrier integrity leakage pro-inflammatory endotoxin lipopolysaccharide into circulation). To mitigate probiotics in patients is (but not always) associated positive clinical markers scores) biomarkers inflammation activation. Meta-analyses complicated by differences probiotic composition, dose level, treatment duration, large, randomized, controlled trials lacking areas. view critical importance deciding whether prescribe (especially children), we suggest DOHaD concept logically extended “gastrointestinal (“GOHaD”) even “microbiotic (“MOHaD”).

Язык: Английский

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