Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(12)
Опубликована: Дек. 24, 2024
Postoperative
cognitive
dysfunction
(POCD)
represents
a
significant
clinical
concern,
particularly
among
elderly
surgical
patients.
It
is
characterized
by
decline
in
performance,
affecting
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
abilities
leads
to
longer
hospital
stays
increased
mortality.
review
provides
comprehensive
overview
of
the
current
progress
understanding
relevant
pathogenic
factors,
possible
mechanisms,
diagnosing,
prevention
treatment
POCD,
as
well
suggesting
future
research
directions.
discusses
neuronal
damage,
susceptible
genes,
central
cholinergic
system,
nervous
system
(CNS)
inflammation,
stress
response
glucocorticoids,
oxidative
development
aiming
uncover
pathological
mechanism
develop
effective
strategies
for
POCD.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 6, 2024
Antibiotics
are
safe,
effective
drugs
and
continue
to
save
millions
of
lives
prevent
long-term
illness
worldwide.
A
large
body
epidemiological,
interventional
experimental
evidence
shows
that
exposure
antibiotics
has
negative
effects
on
human
health.
We
reviewed
the
literature
data
links
between
antibiotic
exposure,
gut
dysbiosis,
chronic
disease
(notably
with
regard
“developmental
origins
health
disease”
(“DOHaD”)
approach).
Molecular
biology
studies
show
systemic
administration
infants
a
rapid
onset
but
also
often
long-lasting
impact
microbial
composition
gut.
Along
other
environmental
factors
(e.g.,
an
unhealthy
“Western”
diet
sedentary
behavior),
induce
which
can
be
defined
as
disruption
previously
stable,
functionally
complete
microbiota.
Gut
dysbiosis
many
harmful
Associations
early-life
have
been
reported
for
diseases,
including
inflammatory
bowel
disease,
celiac
some
cancers,
metabolic
diseases
(obesity
type
2
diabetes),
allergic
autoimmune
disorders,
atherosclerosis,
arthritis,
neurodevelopmental,
neurodegenerative
neurological
diseases.
In
mechanistic
terms,
influences
through
direct
mucosal
immune
pathways,
plus
wide
array
or
indirect
short-chain
fatty
acids,
enteric
nervous
system,
peristaltic
motility,
production
hormones
neurotransmitters,
loss
intestinal
barrier
integrity
leakage
pro-inflammatory
endotoxin
lipopolysaccharide
into
circulation).
To
mitigate
probiotics
in
patients
is
(but
not
always)
associated
positive
clinical
markers
scores)
biomarkers
inflammation
activation.
Meta-analyses
complicated
by
differences
probiotic
composition,
dose
level,
treatment
duration,
large,
randomized,
controlled
trials
lacking
areas.
view
critical
importance
deciding
whether
prescribe
(especially
children),
we
suggest
DOHaD
concept
logically
extended
“gastrointestinal
(“GOHaD”)
even
“microbiotic
(“MOHaD”).
Abstract
The
latest
Yakult
Science
Study
Day
was
held
virtually
on
2
November
2023.
Aimed
at
healthcare
professionals,
researchers,
and
students,
a
variety
of
experts
explored
the
gut
microbiome
research
what
it
means
in
practice.
morning
sessions
discussed
role
health
disease,
rapid
advancements
DNA
sequencing
implications
for
personalised
nutrition,
current
state
evidence
benefits
associated
with
fermented
foods,
prebiotics
probiotics
challenges
involved
interpreting
this
area.
afternoon
session
considered
emerging
microbiota–gut–brain
axis
mediating
effects
food
mood,
bidirectional
impact
menopause
microbiota,
interplay
between
skin
treatment
rare
common
disorders.
ended
an
update
use
faecal
microbiota
transplant
both
clinical
Undoubtedly,
is
as
key
conductor
human
health,
relation
to
gastrointestinal
non-gastrointestinal
outcomes.
As
continues
elucidate
mechanisms
action
confirm
their
trials,
should
be
consideration
within
holistic
approach
moving
forward.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(12)
Опубликована: Дек. 24, 2024
Postoperative
cognitive
dysfunction
(POCD)
represents
a
significant
clinical
concern,
particularly
among
elderly
surgical
patients.
It
is
characterized
by
decline
in
performance,
affecting
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
abilities
leads
to
longer
hospital
stays
increased
mortality.
review
provides
comprehensive
overview
of
the
current
progress
understanding
relevant
pathogenic
factors,
possible
mechanisms,
diagnosing,
prevention
treatment
POCD,
as
well
suggesting
future
research
directions.
discusses
neuronal
damage,
susceptible
genes,
central
cholinergic
system,
nervous
system
(CNS)
inflammation,
stress
response
glucocorticoids,
oxidative
development
aiming
uncover
pathological
mechanism
develop
effective
strategies
for
POCD.
