Trends in Cell Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Май 27, 2025
Background Cognitive impairment is a decline in people’s ability to think, learn, and remember, which has some impact on an individual’s daily activities or social functioning. Microbial toxins metabolites from dysregulated gut microbiota directly interact with the intestinal epithelium. This interaction triggers neuroinflammation neurodegeneration central nervous system, ultimately impairing cognitive function. It been found that modulation of flora can be effective intervention improve dysfunction. study first summarize outline global research status trends this field bibliometric perspective, providing reference guidance for future field. Methods Based Web Science Core Collection (WoSCC) database, Literature published between 1999–2025 was searched. Bibliometric analysis performed using VOSviewer CiteSpace software analyze data countries, institutions, authors, journals, keywords, citations, generate visual maps. Results A total 1,702 pieces related literature were retrieved. The overall trend publication increasing. China largest number papers, Huazhong University & Technology Kim, Dong-Hyun institutions individuals more publications. most frequently cited journal SCI REP-UK . frequent keywords are microbiota, followed by Alzheimer’s disease, impairment, Brain, oxidative stress Inflammation. Conclusion In recent years, application treatment made remarkable progress. Oxidative inflammatory response have become main hotspots patients. gut-brain axis plays important role mechanism action. Short-chain fatty acids focus microbial metabolism. Fecal transplantation technology increasingly being used as emerging method flora. Modifying modifying diet exercise may strategy prevent dysfunction future. Future studies gender differences
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2023, Номер 94, С. 102171 - 102171
Опубликована: Дек. 21, 2023
Язык: Английский
Процитировано
7
Food Bioscience, Год журнала: 2024, Номер 61, С. 104550 - 104550
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
2
Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107561 - 107561
Опубликована: Дек. 1, 2024
Gut microbial dysbiosis or altered gut consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating profound effects on architecture disruption of bacterial phyla ratios, diminished taxonomic diversity, attenuated short-chain fatty acid synthesis. To address these challenges, novel therapeutic strategies targeting microbiome, encompassing probiotic supplementation, prebiotic compounds, faecal microbiota transplantation, rationalised co-pharmacotherapy, show promise attenuating antipsychotic-induced metabolic disruptions while enhancing efficacy. Harnessing such insights, precision medicine approaches transform antipsychotic prescribing practices by identifying patients at risk side based their profiles. This IUPHAR review collates current literature landscape axis its intricate relationship advocating for integrating microbiome assessments management. Such fundamental shift proposing microbiome-informed prescriptions optimise efficacy reduce adverse impacts would align treatments safety, prioritising 'gut-neutral' gut-favourable drugs safeguard long-term patient outcomes therapy.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12125 - 12125
Опубликована: Ноя. 12, 2024
The gut–brain axis (GBA) plays a pivotal role in human health and wellness by orchestrating complex bidirectional regulation influencing numerous critical processes within the body. Over past decade, research has increasingly focused on GBA context of inflammatory bowel disease (IBD). Beyond its well-documented effects GBA–enteric nervous system vagus nerve dysregulation, gut microbiota misbalance—IBD also leads to impairments metabolic cellular functions: mitochondrial dysfunction, cationic transport, cytoskeleton dysregulation. These systemic are currently underexplored relation GBA; however, they crucial for cells’ functioning. This review summarizes studies particular mechanisms IBD. Understanding involvement these may help find new therapeutic targets develop approaches improve quality life IBD patients.
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Shijie huaren xiaohua zazhi, Год журнала: 2024, Номер 32(7), С. 468 - 483
Опубликована: Июль 28, 2024
Язык: Английский
Процитировано
0
Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 13, С. 115 - 122
Опубликована: Сен. 2, 2024
Introduction . Drugs from the group of glucagon-like peptide-1 receptor agonists were originally intended to be used treat patients with type 2 diabetes mellitus. However, their use, a noticeable weight loss effect was noted, which expanded list indications and currently these drugs are prescribed obese individuals, regardless presence On Russian market, semavic (semaglutide) has established itself as an effective treatment for obesity. Aim To assess semaglutide on eating behavior in process loss. Materials methods The literature search carried out using PubMed Google Scholar databases. selection publications according principle open free access, analysis abstracts assessment relevance. Results A total 35 articles selected review: 7 Russian-language 28 foreign sources. Data vast majority show that semavik is at dose 0.5-2.4 mg per week subcutaneously course up 68 weeks. In alternative cases, drug taken orally. maximum 9,6-17,4% initial body weight. most common manifestation complications gastrointestinal disorders, but only small number did they become reason refuse continue therapy. trials drug, reduction calorie intake noted absence external dietary restrictions. Conclusion prescription accompanied by increased self-control when eating. Self-control extends not food, also drinking alcohol. Approximately half indicate improved quality life. Activation metabolism appears associated decrease insulin resistance, increase concentrations, effects cortisol, hypothalamic-pituitary-adrenal axis.
Язык: Английский
Процитировано
0
Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1051 - 1051
Опубликована: Окт. 23, 2024
Emerging research into the human microbiome, an intricate ecosystem of microorganisms residing in and on our bodies, reveals that it plays a pivotal role maintaining health, highlighting potential for microbiome-based interventions to prevent, diagnose, treat, manage myriad diseases. The objective this review is highlight importance microbiome studies enhancing understanding rare genetic epilepsy related neurological disorders. Studies suggest gut acting through gut-brain axis, impacts development severity epileptic conditions children. Disruptions microbial composition can affect neurotransmitter systems, inflammatory responses, immune regulation, which are all critical factors pathogenesis epilepsy. This growing body evidence points microbiome-targeted therapies, such as probiotics or dietary modifications, innovative approaches managing By harnessing power we stand develop more effective personalized treatment strategies children affected by disease other
Язык: Английский
Процитировано
0
Trends in Cell Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0