Navigating the Neurobiology of Migraine: From Pathways to Potential Therapies
Cells,
Год журнала:
2024,
Номер
13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine
is
a
debilitating
neurological
disorder
characterized
by
recurring
episodes
of
throbbing
headaches
that
are
frequently
accompanied
sensory
disturbances,
nausea,
and
sensitivity
to
light
sound
[...]
Язык: Английский
Fibromyalgia: one year in review 2024
Clinical and Experimental Rheumatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 26, 2024
Язык: Английский
Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach
Experimental & Molecular Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Chronic
neuropathic
pain
is
a
debilitating
neuroplastic
disorder
that
notably
impacts
the
quality
of
life
millions
people
worldwide.
This
complex
condition,
encompassing
various
manifestations,
such
as
sciatica,
diabetic
neuropathy
and
postherpetic
neuralgia,
arises
from
nerve
damage
or
malfunctions
in
processing
pathways
involves
biological,
physiological
psychological
processes.
Maladaptive
neuroplasticity,
known
central
sensitization,
plays
critical
role
persistence
chronic
pain.
Current
treatments
for
include
pharmacological
interventions
(for
example,
antidepressants
anticonvulsants),
invasive
procedures
deep
brain
stimulation)
physical
therapies.
However,
these
approaches
often
have
limitations
potential
side
effects.
In
light
challenges,
interest
noninvasive
neuromodulation
techniques
alternatives
complementary
increasing.
These
methods
aim
to
induce
analgesia
while
reversing
maladaptive
plastic
changes,
offering
advantages
over
conventional
practices
methods.
Recent
technological
advancements
spurred
exploration
therapies,
repetitive
transcranial
magnetic
stimulation,
direct
current
stimulation
ultrasound
well
innovative
transformations
into
at
both
preclinical
clinical
levels.
Here
this
review
aims
critically
examine
mechanisms
neuroplasticity
evaluate
efficacy
relief.
By
focusing
on
optimizing
techniques,
we
can
better
assess
their
short-term
long-term
effects,
refine
treatment
variables
ultimately
improve
management.
Язык: Английский
Evaluating the efficacy of transcranial direct current stimulation (tDCS) in managing neuropathic pain-induced emotional consequences: Insights from animal models
Neurophysiologie Clinique,
Год журнала:
2025,
Номер
55(2), С. 103055 - 103055
Опубликована: Янв. 29, 2025
Neuropathic
pain
is
a
global
health
concern
due
to
its
severity
and
detrimental
impact
on
patients'
quality
of
life.
It
primarily
characterized
by
sensory
alterations,
most
commonly
hyperalgesia
allodynia.
As
the
disease
progresses,
patients
with
neuropathic
develop
co-occurring
emotional
disorders,
such
as
anxiety
depression,
which
further
complicate
therapeutic
management.
While
pharmacotherapy
remains
first-line
treatment,
limitations
in
efficacy
prevalence
side
effects
often
leave
insufficient
relief.
Transcranial
direct
current
stimulation
(tDCS),
non-invasive
brain
technique,
has
recently
emerged
promising
alternative
for
chronic
This
review
provides
an
overview
preclinical
studies
examining
tDCS
rodent
models
pain.
specifically
highlights
potential
modulate
emotional-affective
component
pain,
focus
identifying
optimal
cortical
targets
enhance
translational
application
managing
pain-related
disorders.
Язык: Английский
Repetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding
Current Addiction Reports,
Год журнала:
2025,
Номер
12(1)
Опубликована: Фев. 7, 2025
Язык: Английский
Modulation of neural networks and symptom correlated in fibromyalgia: A randomized double-blind multi-group explanatory clinical trial of home-based transcranial direct current stimulation
PLoS ONE,
Год журнала:
2024,
Номер
19(11), С. e0288830 - e0288830
Опубликована: Ноя. 13, 2024
Background
Transcranial
direct
current
stimulation
(tDCS)
might
modulate
neural
activity
and
promote
plasticity
in
patients
with
fibromyalgia
(FM).
This
multi-group
randomized
clinical
trial
compared
home-based
active
tDCS
(HB-a-tDCS)
on
the
left
dorsolateral
prefrontal
cortex
(l-DLPFC)
or
sham
(HB-s-tDCS),
HB-a-tDCS
HB-s-tDCS
primary
motor
(M1)
connectivity
analyses
eight
regions
of
interest
(ROIs)
across
resting-state
electroencephalography
(EEG)
frequencies.
Methods
We
included
48
women
FM,
aged
30
to
65,
randomly
assigned
2:1:2:1
receive
20
sessions
during
minutes
2mA
HB-s-tDCS,
over
l-DLPFC
M1,
respectively.
EEG
recordings
were
obtained
before
after
treatment
eyes
open
(EO)
closed
(EC).
Results
In
EC
condition,
comparing
pre
post-treatment,
decreased
lagged
coherence
delta
frequency
band
between
right
insula
anterior
cingulate
(ACC)
(t
=
-3.542,
p
.048).
The
ACC
-4.000,
.017).
EO
M1
increased
theta
-4.059,
Regression
analysis
demonstrated
that
effect
was
positively
correlated
sleep
quality.
On
other
hand,
pain
catastrophizing.
Conclusions
These
results
show
affects
parts
brain
control
pain’s
emotional
attentional
aspects,
which
are
most
noticeable
at
lower
frequencies
a
rest
state.
oscillations
could
serve
as
marker
associated
its
efficacy
alleviating
symptoms.
Clinical
registration
identifier
[
NCT03843203
].
Язык: Английский