The role of Foxo3a in neuron-mediated cognitive impairment DOI Creative Commons
Qinqin Liu, Guihua Wu,

Xiaochun Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Июнь 19, 2024

Cognitive impairment (COI) is a prevalent complication across spectrum of brain disorders, underpinned by intricate mechanisms yet to be fully elucidated. Neurons, the principal cell population nervous system, orchestrate cognitive processes and govern balance. Extensive inquiry has spotlighted involvement Foxo3a in COI. The regulatory cascade transactivation implicates multiple downstream signaling pathways encompassing mitochondrial function, oxidative stress, autophagy, apoptosis, collectively affecting neuronal activity. Notably, expression activity profile are subject modulation via various modalities, including methylation promoter, phosphorylation acetylation protein. Furthermore, upstream such as PI3K/AKT, SIRT family, diverse micro-RNAs intricately interface with Foxo3a, engendering alterations function. Through several routes, regulates dynamics, thereby modulating onset or amelioration COI Alzheimer’s disease, stroke, ischemic injury, Parkinson’s traumatic injury. potential therapeutic target, clinical drugs small molecules have been preliminarily shown cognitive-enhancing effects that indirectly affect Foxo3a. Particularly noteworthy randomized, controlled, placebo trials illustrating significant enhancement achievable through autophagy modulation. Here, we discussed role neuron-mediated common cognitively impaired diseases.

Язык: Английский

The role of Foxo3a in neuron-mediated cognitive impairment DOI Creative Commons
Qinqin Liu, Guihua Wu,

Xiaochun Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Июнь 19, 2024

Cognitive impairment (COI) is a prevalent complication across spectrum of brain disorders, underpinned by intricate mechanisms yet to be fully elucidated. Neurons, the principal cell population nervous system, orchestrate cognitive processes and govern balance. Extensive inquiry has spotlighted involvement Foxo3a in COI. The regulatory cascade transactivation implicates multiple downstream signaling pathways encompassing mitochondrial function, oxidative stress, autophagy, apoptosis, collectively affecting neuronal activity. Notably, expression activity profile are subject modulation via various modalities, including methylation promoter, phosphorylation acetylation protein. Furthermore, upstream such as PI3K/AKT, SIRT family, diverse micro-RNAs intricately interface with Foxo3a, engendering alterations function. Through several routes, regulates dynamics, thereby modulating onset or amelioration COI Alzheimer’s disease, stroke, ischemic injury, Parkinson’s traumatic injury. potential therapeutic target, clinical drugs small molecules have been preliminarily shown cognitive-enhancing effects that indirectly affect Foxo3a. Particularly noteworthy randomized, controlled, placebo trials illustrating significant enhancement achievable through autophagy modulation. Here, we discussed role neuron-mediated common cognitively impaired diseases.

Язык: Английский

Процитировано

6