Cerebral Amyloid Angiopathy Related Inflammation: A Single-Center Case Series Analysis
Brain Sciences,
Год журнала:
2025,
Номер
15(5), С. 472 - 472
Опубликована: Апрель 29, 2025
Cerebral
amyloid
angiopathy-related
inflammation
(CAA-RI)
is
a
rare
subtype
of
cerebral
angiopathy
(CAA),
which
presents
mostly
as
subacute
and
reversible
encephalopathy.
Primary
symptoms
include
behavioral
changes
cognitive
decline
in
the
form
rapidly
progressive
dementia,
headache,
seizures,
focal
neurological
deficits.
It
can
also
manifest
varied
range
typical
atypical
presentations.
Misdiagnosis
common
because
it
shares
with
other
infectious,
ischemic
autoimmune
pathologies
there
significant
overlap
MRI
findings.
Gold
standard
diagnosis
requires
brain
biopsy
appropriate
clinical
setting,
but
diagnostic
criteria
established
for
probable
possible
CAA-RI
using
findings
absence
inflammatory,
infectious
or
processes.
Immunomodulatory
therapy
mainstay
treatment,
variable
response.
We
present
case
series
three
patients
highlighting
disease
course,
neuroradiological
manifestation,
treatment
response,
outcomes.
provide
literature
review
to
increase
insight
into
this
pathology.
Early
prompt
initiation
immunosuppressive
beneficial
most
cases.
Язык: Английский
CSF and Plasma Biomarkers in Patients With Iatrogenic Cerebral Amyloid Angiopathy
Neurology,
Год журнала:
2024,
Номер
103(8)
Опубликована: Сен. 16, 2024
Recently,
a
subset
of
patients
affected
by
cerebral
amyloid
angiopathy
(CAA)
distinguished
atypical
juvenile
onset
and
hypothesized
iatrogenic
origin
(iatrogenic
CAA,
iCAA)
has
emerged.
β-Amyloid
(Aβ)
accumulation
evidenced
PET
positivity
or
CSF
Aβ
decrease
was
included
in
the
iCAA
diagnostic
criteria.
Conversely,
criteria
for
sporadic
CAA
(sCAA)
do
not
involve
biomarker
analysis.
The
aim
this
study
to
assess
plasma
levels
tau
sCAA
cohorts.
Язык: Английский