Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 226 - 226
Опубликована: Янв. 9, 2025
Background/Objectives:
Decompensated
cirrhosis
is
characterized
by
systemic
inflammation
and
innate
adaptive
immune
dysfunction.
Hepatic
encephalopathy
(HE)
a
prevalent
debilitating
condition
cognitive
disturbances
in
which
ammonia
play
synergistic
pathogenic
role.
Extraskeletal
functions
of
vitamin
D
include
immunomodulation,
its
deficiency
has
been
implicated
dysfunction
different
forms
impairment.
The
aim
was
to
assess
changes
function
decompensated
patients
with
receiving
supplementation.
Methods:
Patients
discharged
from
decompensation
two
tertiary
hospitals
Spain
(from
September
2017
January
2020)
were
assessed
before,
at
6
12
months
after
A
comprehensive
neuropsychological
battery
neuroinflammatory
markers
examined.
In
subgroup
patients,
peripheral
blood
cells
analyzed.
Results:
Thirty-nine
recruited.
Of
those,
27
completed
the
evaluation
analyzed
[age
62.4
±
11.3
years;
22
men;
Model
for
End-Stage
Liver
Disease
(MELD)
11.7
4.0;
prior
overt
HE
33%;
median
25-hydroxyvitamin
(25OHD)
plasma
level
12.7
µgr/L]
achieved
assessment.
At
baseline,
learning
memory
(R
=
0.382;
p
0.049)
working
0.503;
0.047)
subtests
correlated
25OHD
levels.
addition,
processing
speed
−0.42;
0.04),
attention
−0.48;
Tinnetti
balance
−0.656;
<
0.001)
score
−0.659;
linked
neuroinflammation
marker
IL-1β.
lower
had
greater
proportion
TH1cells
baseline
larger
amelioration
IL-1β
IL-6
following
An
improvement
found
replacement
(46.7
13
50
11;
0.047).
Conclusions:
This
study
supports
that
supplementation
modulates
low-grade
providing
benefits,
particularly
memory.
Язык: Английский
Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 20, 2025
Neuroinflammation
is
an
increasingly
important
target
for
therapeutics
in
neuropsychiatry
and
contributes
to
cognitive
dysfunction,
disability
death
across
a
range
of
illnesses.
We
previously
found
that
acute
effects
pro-inflammatory
stimulation
with
lipopolysaccharide
(LPS)
on
hippocampal
long-term
potentiation
(LTP),
form
synaptic
plasticity
involved
learning
memory,
requires
synthesis
the
oxysterol,
25-hydroxycholesterol
(25HC)
exogenous
25HC
mimics
LPS.
However,
downstream
mechanisms
engaged
by
LPS
remain
uncertain.
Here
we
use
rat
slices
vivo
behavioral
studies
provide
evidence
modulation
both
activation
NLRP3
inflammasome,
caspase-1
interleukin-1
receptor.
Furthermore,
engage
cellular
stress
responses
including
5α-reduced
neurosteroids
are
prevented
modulators
these
responses.
In
using
one-trial
inhibitory
avoidance
task,
inhibition
pre-treatment
inhibitor
NLRP3.
The
present
strong
support
role
as
mediator
importance
inflammasome
deleterious
inflammation.
Язык: Английский
A comprehensive review on neurotrophic receptors and their implications in brain health: Exploring the neuroprotective potential of berries
Journal of Berry Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
Neurotrophic
receptors
are
specialized
proteins
on
the
surface
of
neurons
that
regulate
growth,
development,
and
survival
nerve
cells,
interacting
with
specific
neurotrophic
factors
to
support
neuronal
function
overall
brain
health.
Key
examples
include
tropomyosin
receptor
kinase
(Trk)
family
p75
neurotrophin
receptor.
This
review
highlights
neuroprotective
potential
berries
such
as
blueberries,
strawberries,
raspberries,
blackberries
known
for
their
rich
content
bioactive
compounds,
including
polyphenols,
flavonoids,
anthocyanins.
These
phytochemicals
possess
antioxidant
anti-inflammatory
properties
may
play
a
critical
role
in
neuroprotection.
Emerging
evidence
from
clinical
trials
suggests
berry
consumption
can
enhance
cognitive
provide
protection
against
age-related
neurodegenerative
diseases.
Notably,
modulation
signaling
pathways
related
neurotransmission,
cell
survival,
inflammation,
neuroplasticity
underscores
significance
these
fruits
uniquely
synthesizes
recent
findings
influenced
by
berry-derived
phytochemicals,
providing
insights
into
mechanisms
action.
Furthermore,
we
explore
implications
compounds
developing
functional
foods
aimed
at
preventing
neurodegeneration
promoting
health,
thereby
contributing
growing
body
research
dietary
interventions
Язык: Английский
Exploring and Validating the Mechanism of Ulinastatin in the Treatment of Sepsis-Associated Encephalopathy Based on Transcriptome Sequencing
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 8753 - 8773
Опубликована: Ноя. 1, 2024
Sepsis
can
induce
sepsis-associated
encephalopathy
(SAE),
with
Ulinastatin
(UTI)
serving
a
critical
anti-inflammatory
role.
This
study
aimed
to
identify
the
hub
genes
in
an
SAE
mouse
model
following
UTI
intervention
and
investigate
underlying
molecular
mechanisms.
Through
differential
expression
analysis
obtain
differentially
expressed
(DEGs),
ie,
vs
CLP
(DEGs1)
Con
(DEGs2).
After
taking
intersection
of
opposite
trends
these
two
parts
immune-related
(IRGs),
DE-IRGs
were
obtained.
Hub
protein-protein
interaction
(PPI)
network
then
determined
using
six
algorithms
from
Cytohubba
plugin
Cytoscape.
Gene
set
enrichment
(GSEA)
was
employed
explore
functional
relevance
genes.
Additionally,
immune
microenvironment
across
three
groups
compared,
gene-related
drugs
predicted
online
database.
Finally,
qRT-PCR
used
validate
hippocampal
tissue
mice.
RNA
sequencing
obtained
864
(DEGs)
(CLP
Con)
279
DEGs
(UTI
CLP).
Taking
yielded
165
DEGs.
Six
key
(ICAM
-
1,
IRF7,
IL
1β,
CCL2,
6
SOCS3)
screened
by
algorithms.
Immune
infiltration
found
that
Treg
cells
reversed
after
treatment
diseased
state.
A
total
106
gene
related
predicted,
among
which
BINDARIT
CCL2
LIFITEGRAST
ICAM1
showed
particularly
high
affinities.
The
qRT
PCR
verification
results
consistent
results.
In
conclusion,
ICAM-1,
IL-1β,
IL-6,
SOCS3
identified
as
potential
therapeutic
targets
mice
treated
UTI.
offers
theoretical
support
for
option
SAE.
Язык: Английский