Preclinical Retinal Disease Models: Applications in Drug Development and Translational Research DOI Creative Commons
Sudha Priya Soundara Pandi, Hanagh R. Winter, Madeleine Smith

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 293 - 293

Опубликована: Фев. 21, 2025

Retinal models play a pivotal role in translational drug development, bridging preclinical research and therapeutic applications for both ocular systemic diseases. This review highlights the retina as an ideal organ studying advanced therapies, thanks to its immune privilege, vascular neuronal networks, accessibility, imaging capabilities. Preclinical retinal disease offer unparalleled insights into inflammation, angiogenesis, fibrosis, hypoxia, utilizing clinically translatable bioimaging tools like fundoscopy, optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein angiography, optokinetic tracking, electroretinography. These have driven innovations anti-inflammatory, anti-angiogenic, neuroprotective strategies, with broader implications diseases such rheumatoid arthritis, Alzheimer’s, fibrosis-related conditions. By emphasizing integration of 3Rs principles novel modalities, this how not only enhances precision but also minimizes ethical concerns, paving way more predictive human-relevant approaches development.

Язык: Английский

Preclinical Retinal Disease Models: Applications in Drug Development and Translational Research DOI Creative Commons
Sudha Priya Soundara Pandi, Hanagh R. Winter, Madeleine Smith

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 293 - 293

Опубликована: Фев. 21, 2025

Retinal models play a pivotal role in translational drug development, bridging preclinical research and therapeutic applications for both ocular systemic diseases. This review highlights the retina as an ideal organ studying advanced therapies, thanks to its immune privilege, vascular neuronal networks, accessibility, imaging capabilities. Preclinical retinal disease offer unparalleled insights into inflammation, angiogenesis, fibrosis, hypoxia, utilizing clinically translatable bioimaging tools like fundoscopy, optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein angiography, optokinetic tracking, electroretinography. These have driven innovations anti-inflammatory, anti-angiogenic, neuroprotective strategies, with broader implications diseases such rheumatoid arthritis, Alzheimer’s, fibrosis-related conditions. By emphasizing integration of 3Rs principles novel modalities, this how not only enhances precision but also minimizes ethical concerns, paving way more predictive human-relevant approaches development.

Язык: Английский

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