Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications

Nutrients, Год журнала: 2021, Номер 13(1), С. 249 - 249

Опубликована: Янв. 16, 2021

Studies suggest that the bidirectional relationship existent between gut microbiome (GM) and central nervous system (CNS), or so-called microbiome–gut–brain axis (MGBA), is involved in diverse neuropsychiatric diseases children adults. In pediatric age, most studies have focused on patients with autism. However, evidence of role played by MGBA attention deficit/hyperactivity disorder (ADHD), common neurodevelopmental childhood, still scanty heterogeneous. This review aims to provide current functioning ADHD specific omega-3 polyunsaturated fatty acids (ω-3 PUFAs) this interaction, as well potential GM a therapeutic target for ADHD. We will explore: (1) communication pathways CNS; (2) changes composition adolescents association pathophysiology; (3) influence ω-3 PUFA imbalance characteristically found ADHD; (4) interaction circadian rhythm regulation, sleep disorders are frequently comorbid (5) finally, we evaluate recent use probiotics

Язык: Английский

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Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Окт. 11, 2021

The gut–brain axis refers to the bidirectional communication between gut and brain, regulates intestinal homeostasis central nervous system via neural networks neuroendocrine, immune, inflammatory pathways. development of sequencing technology has evidenced key regulatory role microbiota in several neurological disorders, including Parkinson’s disease, Alzheimer’s multiple sclerosis. Epilepsy is a complex disease with risk factors that affect more than 50 million people worldwide; nearly 30% patients epilepsy cannot be controlled drugs. Interestingly, bowel are susceptible epilepsy, ketogenic diet an effective treatment for intractable epilepsy. Based on these clinical facts, microbiome ignored. In this review, we discuss relationship summarize possible pathogenic mechanisms from perspective axis, novel therapies targeting microbiota. A better understanding especially one, would help investigate mechanism, diagnosis, prognosis evaluation,

Язык: Английский

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Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2019, Номер 144, С. 427 - 440

Опубликована: Дек. 18, 2019

Язык: Английский

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The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials

Complementary Therapies in Medicine, Год журнала: 2020, Номер 49, С. 102361 - 102361

Опубликована: Фев. 27, 2020

Язык: Английский

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The gut microbiome in epilepsy

Microbial Pathogenesis, Год журнала: 2019, Номер 139, С. 103853 - 103853

Опубликована: Ноя. 13, 2019

Язык: Английский

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