Synergizing Artificial Intelligence and Probiotics: A Comprehensive Review of Emerging Applications in Health Promotion and Industrial Innovation

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104938 - 104938

Опубликована: Фев. 1, 2025

Язык: Английский

---

Neuro-immune-cancer interactions: Mechanisms and therapeutic implications for tumor modulation

Brain Behavior and Immunity Integrative, Год журнала: 2025, Номер 10, С. 100119 - 100119

Опубликована: Апрель 1, 2025

Язык: Английский

---

Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Neuroscience, Год журнала: 2024, Номер 565, С. 63 - 79

Опубликована: Ноя. 26, 2024

Язык: Английский

---

Leveraging artificial intelligence (AI) and machine learning (ML) for enhanced drug discovery and development from microbes

Methods in microbiology, Год журнала: 2024, Номер unknown, С. 125 - 140

Опубликована: Янв. 1, 2024

Язык: Английский

---

Personalized auricular vagus nerve stimulation: beat-to-beat deceleration dominates in systole-gated stimulation during inspiration - a pilot study

Frontiers in Physiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve modulation target. The auricular stimulation (aVNS) has emerged to treat chronic diseases while re-establishing sympathovagal balance and activating parasympathetic anti-inflammatory pathways. aVNS leads still over under-stimulation is limited in therapeutic efficiency. A potential avenue personalization of based on time-varying cardiorespiratory rhythms human body. In pilot study, we propose personalized cardiac-gated evaluate its effects instantaneous beat-to-beat intervals (RR intervals). Modulation RR expected reveal efficiency since efferent cardiac branch stimulated afferent governs RR. Five healthy subjects were subjected aVNS. Each subject underwent two 25-min sessions. first session started non-gated open-loop aVNS, followed by systole-gated closed-loop then non-gated, diastole-gated, each for 5min. second session, systole diastole gated interchanged. Changes are analysed comparing prolongation respect proceeding interval where took place. These changes considered function onset, angle starting R peak. influence respiration phases cardiovagal modulation. results show that tends prolong shorten when after before peak, respectively. later time onset within diastole-gated longer be subsequent interval. tendency raises increasing gradually levels off delay from one slope this rise larger than When considering individual phases, inspiratory seems largest values thus modulatory capacity time-gated This study indicates modulate heartbeat activity which attenuated diseases. highest during inspiration.

Язык: Английский

---

Biochemical strategies for opioid-sparing pain management in the operating room

Biochemistry and Biophysics Reports, Год журнала: 2025, Номер 41, С. 101927 - 101927

Опубликована: Янв. 25, 2025

Язык: Английский

---

Adopting Technological Innovations to Enhance Disaster Event Response

Disaster Medicine and Public Health Preparedness, Год журнала: 2025, Номер 19

Опубликована: Янв. 1, 2025

Abstract The convergence of medical and technological developments has continued to transform the delivery care in disaster environments, incorporating advances from telecommunications physiologic monitoring, artificial intelligence, computer vision. However, unless interconnected nature these is conceptualized with a proper framework, there risk overlooking applications, developing silos, limiting interoperability between innovations. To develop such this piece integrated review current literature, expert insights, global market trends propose 4 categories innovations: (1) Enabling Technologies, (2) Signal Acquisition, (3) Data Utilization, (4) Applications. Applications can be further subdivided into use cases: Disease Injury Surveillance Detection, Population Protection, Responder Management. Practitioners, policymakers, private sector counterparts utilize framework change their clinical practices, allocate funds stepwise fashion, or prioritize development projects, respectively.

Язык: Английский

---

Drugs of abuse drive neurotransmitter plasticity that alters behavior: implications for mental health

Frontiers in Behavioral Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 19, 2025

Neurotransmission is a complex process with multiple levels of regulation that, when altered, can significantly impact mental health. Neurons in the adult brain release more than one transmitter and environmental stimuli change type neurons express. Changes express generate changes animal behavior. The ability to transmitters and/or switch them response likely evolved provide flexibility complexity neuronal circuit function an ever-changing environment. However, this adaptability become maladaptive generating behavioral alterations that are unfit for environment which lives or tasks it needs perform. Repeated exposure addictive substances induces long-lasting molecular synaptic changes, driving appearance behaviors result drug misuse addiction. Recent findings have shown way drugs abuse alter by inducing Here, we review evidence prolonged number expressing neuropeptide orexin, neuromodulator dopamine, inhibitory GABA. These show drug-induced plasticity conserved across species, belonging different classes chemicals induce same plasticity, only cause types they Importantly, contributes long-term negative effects consumption, can, some cases, be either prevented reversed alleviate these outcomes. Regional hyperactivity appears modulate stabilization expression, no longer observed activity normalized. Overall, underscore importance continuing investigate extent significance neurotransmitter exploring whether non-invasive strategies used reverse as means mitigate use.

Язык: Английский

---

Bioelectronic Hydrogels: Exemplifying the Synergy Between Biopolymers and Conjugated Polymers

Macromolecular Materials and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Conductive hydrogels are a potential platform for 3D cell culture, especially in bioelectronic interfaces, enabling the integration of electronic and mechanical signals as biological cues. Biopolymer‐based conductive offer significant advantages thanks to their inherent flexibility renewable biocompatible properties, combination with conductivity hydrogel network. However, hydrogels' vulnerability failure limits durability applications. To address this, self‐healing reversible dynamic networks have emerged. These materials capable repairing themselves after damage closely mimic healing characteristics living tissues. This capability thus promotes reliable long‐lasting use devices. review first examines individual hydrogels, namely electrical from conjugated polymer cues biopolymer, terms influence on cellular activities. Subsequently, recent advancements biopolymer‐based discussed, focus fabrication method ability modulate specific functions. Finally, bioelectronics summarized, focusing variety mechanisms corollaries enhanced longevity.

Язык: Английский

---

Remote‐Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model

Advanced Materials Technologies, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract Wound healing is a significant opportunity in biomedical science, requiring precise therapeutic delivery and real‐time monitoring. Bioelectronic devices address this need require further validation large animal models that reflect human dynamics. This work introduces wireless, remotely controlled bioelectronic platform with an iontophoretic pump to deliver fluoxetine, selective serotonin reuptake inhibitor modulates inflammation promotes wound repair. Treatment over 3 days porcine model increased re‐epithelialization by 37% reduced inflammation, as shown 33% decrease the ratio of pro‐inflammatory M1 macrophages pro‐reparative M2 compared controls. The accelerated early stimulated neuronal growth at site.

Язык: Английский

---