World Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
16(10), С. 4055 - 4059
Опубликована: Сен. 25, 2024
In
this
editorial,
we
provide
commentary
on
six
articles
recently
published
in
the
World
Journal
of
Gastrointestinal
Oncology
.
These
collectively
present
latest
findings
field
gastric
and
colorectal
cancer
(CRC)
research.
The
global
incidence
varies
based
geographical
location,
age,
sex.
disease
predominantly
affects
middle-aged
elderly
individuals,
with
a
slightly
higher
prevalence
men
than
women.
CRC
is
characterized
by
low
5-year
survival
rate
high
mortality
rate.
It
primarily
individuals
over
age
50,
risk
increases
age.
Both
pose
significant
health
threats,
thus
requiring
more
effective
diagnostic,
therapeutic,
supportive
care
strategies
to
improve
patient
outcomes.
discussed
editorial
encompass
topics
such
as
screening,
diagnosis,
mechanisms
progression,
postoperative
recovery
CRC,
offer
valuable
insights
for
clinical
decision-making
treatment,
prognosis
gastrointestinal
cancers.
Bioelectronic Medicine,
Год журнала:
2024,
Номер
10(1)
Опубликована: Сен. 13, 2024
Abstract
The
identification
of
acute
cardioprotective
strategies
against
myocardial
ischemia/reperfusion
(I/R)
injury
that
can
be
applied
in
the
catheterization
room
is
currently
an
unmet
clinical
need
and
several
interventions
evaluated
past
at
pre-clinical
level
have
failed
translation.
Autonomic
imbalance,
sustained
by
abnormal
afferent
signalling,
a
key
component
I/R
injury.
Accordingly,
there
strong
rationale
for
neuromodulation
strategies,
aimed
reducing
sympathetic
activity
and/or
increasing
vagal
tone,
this
setting.
In
review
we
focus
on
cervical
nerve
stimulation
(cVNS)
transcutaneous
auricular
vagus
(taVNS);
latest
has
potential
to
overcome
issues
invasive
cVNS,
including
possibility
being
used
setting,
while
retaining
its
beneficial
effects.
First,
discuss
pathophysiology
injury,
mostly
consequence
overproduction
reactive
oxygen
species.
Second,
describe
functional
anatomy
parasympathetic
branch
autonomic
nervous
system
most
relevant
principles
bioelectronic
medicine
electrical
modulation,
with
particular
taVNS.
Then,
provide
detailed
comprehensive
summary
studies
non-invasive
VNS
support
effect
whenever
or
chronic
cardiac
specifically
setting
benefit
emerging
field
post
arrest
syndrome
(PCAS)
also
mentioned.
Indeed,
cVNS
anti-adrenergic,
anti-inflammatory,
antioxidants,
anti-apoptotic
pro-angiogenic
effect;
involved
molecular
pathways
were
already
directly
confirmed
take
place
Pre-clinical
data
clearly
show
sooner
applied,
better
outcome,
marked
infarct
size
reduction
almost
complete
left
ventricular
reverse
remodelling
when
immediately
before
during
reperfusion.
Finally,
detail
limited
but
very
promising
experience
taVNS
available
so
far.
Frontiers in Physiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Neuromodulation
comes
into
focus
as
a
non-pharmacological
therapy
with
the
vagus
nerve
modulation
target.
The
auricular
stimulation
(aVNS)
has
emerged
to
treat
chronic
diseases
while
re-establishing
sympathovagal
balance
and
activating
parasympathetic
anti-inflammatory
pathways.
aVNS
leads
still
over
under-stimulation
is
limited
in
therapeutic
efficiency.
A
potential
avenue
personalization
of
based
on
time-varying
cardiorespiratory
rhythms
human
body.
In
pilot
study,
we
propose
personalized
cardiac-gated
evaluate
its
effects
instantaneous
beat-to-beat
intervals
(RR
intervals).
Modulation
RR
expected
reveal
efficiency
since
efferent
cardiac
branch
stimulated
afferent
governs
RR.
Five
healthy
subjects
were
subjected
aVNS.
Each
subject
underwent
two
25-min
sessions.
first
session
started
non-gated
open-loop
aVNS,
followed
by
systole-gated
closed-loop
then
non-gated,
diastole-gated,
each
for
5min.
second
session,
systole
diastole
gated
interchanged.
Changes
are
analysed
comparing
prolongation
respect
proceeding
interval
where
took
place.
These
changes
considered
function
onset,
angle
starting
R
peak.
influence
respiration
phases
cardiovagal
modulation.
results
show
that
tends
prolong
shorten
when
after
before
peak,
respectively.
later
time
onset
within
diastole-gated
longer
be
subsequent
interval.
tendency
raises
increasing
gradually
levels
off
delay
from
one
slope
this
rise
larger
than
When
considering
individual
phases,
inspiratory
seems
largest
values
thus
modulatory
capacity
time-gated
This
study
indicates
modulate
heartbeat
activity
which
attenuated
diseases.
highest
during
inspiration.
Disaster Medicine and Public Health Preparedness,
Год журнала:
2025,
Номер
19
Опубликована: Янв. 1, 2025
Abstract
The
convergence
of
medical
and
technological
developments
has
continued
to
transform
the
delivery
care
in
disaster
environments,
incorporating
advances
from
telecommunications
physiologic
monitoring,
artificial
intelligence,
computer
vision.
However,
unless
interconnected
nature
these
is
conceptualized
with
a
proper
framework,
there
risk
overlooking
applications,
developing
silos,
limiting
interoperability
between
innovations.
To
develop
such
this
piece
integrated
review
current
literature,
expert
insights,
global
market
trends
propose
4
categories
innovations:
(1)
Enabling
Technologies,
(2)
Signal
Acquisition,
(3)
Data
Utilization,
(4)
Applications.
Applications
can
be
further
subdivided
into
use
cases:
Disease
Injury
Surveillance
Detection,
Population
Protection,
Responder
Management.
Practitioners,
policymakers,
private
sector
counterparts
utilize
framework
change
their
clinical
practices,
allocate
funds
stepwise
fashion,
or
prioritize
development
projects,
respectively.
Frontiers in Behavioral Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Март 19, 2025
Neurotransmission
is
a
complex
process
with
multiple
levels
of
regulation
that,
when
altered,
can
significantly
impact
mental
health.
Neurons
in
the
adult
brain
release
more
than
one
transmitter
and
environmental
stimuli
change
type
neurons
express.
Changes
express
generate
changes
animal
behavior.
The
ability
to
transmitters
and/or
switch
them
response
likely
evolved
provide
flexibility
complexity
neuronal
circuit
function
an
ever-changing
environment.
However,
this
adaptability
become
maladaptive
generating
behavioral
alterations
that
are
unfit
for
environment
which
lives
or
tasks
it
needs
perform.
Repeated
exposure
addictive
substances
induces
long-lasting
molecular
synaptic
changes,
driving
appearance
behaviors
result
drug
misuse
addiction.
Recent
findings
have
shown
way
drugs
abuse
alter
by
inducing
Here,
we
review
evidence
prolonged
number
expressing
neuropeptide
orexin,
neuromodulator
dopamine,
inhibitory
GABA.
These
show
drug-induced
plasticity
conserved
across
species,
belonging
different
classes
chemicals
induce
same
plasticity,
only
cause
types
they
Importantly,
contributes
long-term
negative
effects
consumption,
can,
some
cases,
be
either
prevented
reversed
alleviate
these
outcomes.
Regional
hyperactivity
appears
modulate
stabilization
expression,
no
longer
observed
activity
normalized.
Overall,
underscore
importance
continuing
investigate
extent
significance
neurotransmitter
exploring
whether
non-invasive
strategies
used
reverse
as
means
mitigate
use.
