Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

JMIR Bioinformatics and Biotechnology, Год журнала: 2024, Номер 5, С. e65506 - e65506

Опубликована: Дек. 16, 2024

Background Health care students often experience high levels of stress, anxiety, and mental health issues, making it crucial to address these challenges. Variations in stress may be associated with changes dehydroepiandrosterone sulfate (DHEA-S) interleukin-6 (IL-6) gene expression. Meditative practices have demonstrated effectiveness reducing improving well-being. Objective This study aims assess the effects Heartfulness meditation on well-being, DHEA-S, IL-6, expression profile. Methods The 78 enrolled participants were randomly assigned (n=42, 54%) control (n=36, 46%) groups. completed Perceived Stress Scale (PSS) Depression Anxiety (DASS-21) at baseline after week 12. Gene messenger RNA sequencing DHEA-S IL-6 also measured completion 12 weeks. Statistical analysis included descriptive statistics, paired t test, 1-way ANOVA Bonferroni correction. Results group exhibited a significant 17.35% reduction PSS score (from mean 19.71, SD 5.09 16.29, 4.83; P<.001) compared nonsignificant 6% (P=.31). DASS-21 scores decreased significantly by 27.14% 21.15, 9.56 15.41, 7.87; while increased nonsignificantly 17% (P=.04). For subcomponents—the showed statistically 28.53% anxiety (P=.006) 27.38% (P=.002) versus an insignificant 22% increase (P=.02) (P=.47) group. Further, 20.27% 251.71, 80.98 302.74, 123.56; P=.002) 9% 285.33, 112.14 309.90, 136.90; P=.10). difference both groups 4.93, 1.35 3.67, 1.0; 28.6%; P<.001 [Heartfulness group] from 4.52, 1.40 2.72, 1.74; 40%; [control group]). Notably, comparison weeks revealed perceived its subcomponents, (all P<.05/4). profile identified 875 upregulated genes 1539 downregulated baseline, there 292 1180 intervention. Conclusions practice was depression, improved measures levels. data point toward possible mechanisms alleviation symptoms depression. Trial Registration ISRCTN Registry ISRCTN82860715; https://doi.org/10.1186/ISRCTN82860715

Язык: Английский

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Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial (Preprint)

Опубликована: Авг. 17, 2024

Health care students often experience high levels of stress, anxiety, and mental health issues, making it crucial to address these challenges. Variations in stress may be associated with changes dehydroepiandrosterone sulfate (DHEA-S) interleukin-6 (IL-6) gene expression. Meditative practices have demonstrated effectiveness reducing improving well-being. This study aims assess the effects Heartfulness meditation on well-being, DHEA-S, IL-6, expression profile. The 78 enrolled participants were randomly assigned (n=42, 54%) control (n=36, 46%) groups. completed Perceived Stress Scale (PSS) Depression Anxiety (DASS-21) at baseline after week 12. Gene messenger RNA sequencing DHEA-S IL-6 also measured completion 12 weeks. Statistical analysis included descriptive statistics, paired <i>t</i> test, 1-way ANOVA Bonferroni correction. group exhibited a significant 17.35% reduction PSS score (from mean 19.71, SD 5.09 16.29, 4.83; <i>P</i>&lt;.001) compared nonsignificant 6% (<i>P</i>=.31). DASS-21 scores decreased significantly by 27.14% 21.15, 9.56 15.41, 7.87; while increased nonsignificantly 17% (<i>P</i>=.04). For subcomponents—the showed statistically 28.53% anxiety (<i>P</i>=.006) 27.38% (<i>P</i>=.002) versus an insignificant 22% increase (<i>P</i>=.02) (<i>P</i>=.47) group. Further, 20.27% 251.71, 80.98 302.74, 123.56; <i>P</i>=.002) 9% 285.33, 112.14 309.90, 136.90; <i>P</i>=.10). difference both groups 4.93, 1.35 3.67, 1.0; 28.6%; <i>P</i>&lt;.001 [Heartfulness group] from 4.52, 1.40 2.72, 1.74; 40%; [control group]). Notably, comparison weeks revealed perceived its subcomponents, (all <i>P</i>&lt;.05/4). profile identified 875 upregulated genes 1539 downregulated baseline, there 292 1180 intervention. practice was depression, improved measures levels. data point toward possible mechanisms alleviation symptoms depression. ISRCTN Registry ISRCTN82860715; https://doi.org/10.1186/ISRCTN82860715

Язык: Английский

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Sintomas de depressão e ansiedade em estudantes de medicina de uma universidade pública de São Paulo: relação com a qualidade do sono

Revista Eletrônica Acervo Saúde, Год журнала: 2024, Номер 24(3), С. e14939 - e14939

Опубликована: Март 8, 2024

Objetivo: Identificar a proporção de estudantes medicina uma universidade pública com sintomas depressão, ansiedade, insônia, má qualidade do sono, e seus fatores determinantes. Métodos: Trata-se um estudo transversal tipo survey. Foi enviado formulário questões sociodemográficas os questionários sono Pittsburgh, sonolência Epworth ansiedade depressão Beck. A coleta dados ocorreu entre agosto 2021 janeiro 2022. feita análise estatística descritiva cálculo medidas associação. O foi aprovado pelo Comitê Ética em Pesquisa. Resultados: amostra contou 53 estudantes, predominando mulheres (52,8%), idades 18 29 anos (84,9%), raça branca (67,9%). Os foram reportados por 83% 50,9% dos participantes, respectivamente. Observou-se excessiva diurna 15% enquanto 77,4% pontuaram para sono. Demonstrou-se correlação positiva moderada saúde mental escala Pittsburgh. aumentaram probabilidade (OR 28,4; IC 95% 1,75-149). Conclusão: Na população medicina, podem comprometer negativamente

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The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review

Molecules, Год журнала: 2024, Номер 29(9), С. 1930 - 1930

Опубликована: Апрель 23, 2024

The phenyl(piperidin-4-yl)methanone fragment (here referred to as the benzoylpiperidine fragment) is a privileged structure in development of new drugs considering its presence many bioactive small molecules with both therapeutic (such anti-cancer, anti-psychotic, anti-thrombotic, anti-arrhythmic, anti-tubercular, anti-parasitic, anti-diabetic, and neuroprotective agents) diagnostic properties. metabolically stable, it also considered potential bioisostere piperazine ring, thus making feasible reliable chemical frame be exploited drug design. Herein, we discuss main agents presenting motif their structure, covering articles reported literature since 2000. A specific section focused on synthetic strategies adopted obtain this versatile portion.

Язык: Английский

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Targeting serotonin receptors with phytochemicals – an in-silico study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 5, 2024

The potential of natural phytochemicals in mitigating depression has been supported by substantial evidence. This study evaluated a total 88 with antidepressant properties targeting serotonin (5-HT) receptors (5-HT1A, 5-HT4, and 5-HT7) using molecular docking, ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) analysis, internal coordinates normal mode analysis (NMA), dynamics simulation (MDS), free energy calculation. Five compounds (Genistein, Kaempferol, Daidzein, Peonidin, glycitein) exhibited favorable pharmacokinetic improved binding scores, indicating their as effective antidepressants. Redocking superimposition 5-HT cocrystal structures validated these findings. Furthermore, NMA, MDS, calculations confirmed the stability deformability ligand-receptor complexes, suggesting that can effectively interact to modulate depressive symptoms. These powerful phytochemicals, abundantly found soybeans, fruits, vegetables, herbs, represent promising avenue for developing treatments depression. Further vitro vivo studies are warranted explore efficacy alleviating stress through interactions receptors.

Язык: Английский

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