Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat DOI Creative Commons
Seyed Mohammadali Rahmati, Alexander N. Klishko,

Ramaldo S. Martin

и другие.

The Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract Previous studies established strong links between morphological characteristics of mammalian hindlimb muscles and their sensorimotor functions during locomotion. Less is known about the role forelimb morphology in motor outputs generation sensory signals. Here, we measured 46 from six cats. These included muscle attachments, physiological cross‐sectional area (PCSA) fascicle length. We also recorded full‐body mechanics EMG activity level overground treadmill locomotion seven 16 adult cats either sex, respectively. computed forces along with force‐ length‐dependent signals mapped onto corresponding cervical spinal segments. found that patterns afferent activities were strongly affected by muscle's moment arm, PCSA Morphology shoulder suggests distinct roles forelimbs lateral force production movements. Patterns long fibres (brachioradialis, extensor carpi radialis) closely matched overall length, whereas pattern biceps brachii length afferents orientation. conclude cat contributes substantially to locomotor function, particularly control stability turning, rather than propulsion. image Key points Little producing generating somatosensory This information needed understand contributions control. forelimbs, walking electromyographic activity, arms, velocity, activation, muscles, as well length‐ force‐dependent walking. demonstrated contribute proprioceptive regulation cycle phase transitions stability. The obtained can guide development biologically accurate neuromechanical models quadrupedal for exploring testing novel methods treatments central nervous system pathologies modulating neural pathways controlling forelimbs/arms.

Язык: Английский

Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats DOI Creative Commons

Stephen Mari,

Charly G. Lecomte,

Angèle N. Merlet

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 15, 2023

Abstract When the foot dorsum contacts an obstacle during locomotion, cutaneous afferents signal central circuits to coordinate muscle activity in four limbs. Spinal cord injury disrupts these interactions, impairing balance and interlimb coordination. We evoked reflexes by electrically stimulating left right superficial peroneal nerves before after two thoracic lateral hemisections placed on opposite sides of at 9-13 weeks interval seven adult cats (4 males 3 females). recorded reflex responses ten hindlimb five forelimb muscles bilaterally. After first (right T5-T6) second (left T10-T11) hemisections, coordination fore- hindlimbs was altered and/or became less consistent. hemisection, required assistance perform quadrupedal locomotion. Short-latency homonymous crossed largely remained unaffected staggered hemisections. However, mid- long-latency both occurred frequently In muscles, homolateral diagonal response occurrence significantly decreased all limbs, however, when present, short-, maintained their phase-dependent modulation. also observed reduced durations short-latency inhibitory extensors early hemisection delayed ipsilesional hemisection. Therefore, changes correlated with impaired balance/stability locomotion spinal injury. Restoring transmission could be used as a biomarker facilitate locomotor recovery. Key points Cutaneous afferent inputs limbs obstacle. Thoracic communication between centers located cervical lumbar levels, limb investigated nerve bilaterally, cats. showed loss/reduction which balance. Targeting pathways projecting help develop therapeutic approaches aimed restoring ascending descending pathways.

Язык: Английский

Процитировано

1
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection DOI Open Access
Ilya A. Rybak, Natalia A. Shevtsova, Johannie Audet

и другие.

Опубликована: Дек. 9, 2024

Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following cord injury. The thoracic lateral hemisection represents an experimental model of incomplete injury, where connections between brain abolished on one side cord. To investigate effects such injury operation locomotor network, we used our computational cat locomotion recently published in eLife (Rybak et al., 2024) to predict changes cycle phase durations a during treadmill tied-belt (equal left-right speeds) split-belt (unequal conditions. In simulations, “hemisection” was always applied right side. Based model, hypothesized hemisection, contralesional (“intact”, left) network mostly drives, whereas ipsilesional (“hemisected”, right) somatosensory feedback. We then compared simulated results those obtained experiments adult cats before after mid-thoracic same Our confirmed many predicted simulations. show having hindlimb step slow belt, but not fast substantially reduces hemisection. provides explanations for temporal characteristics based altered circuits,

Язык: Английский

Процитировано

0
ROLE OF FORELIMB MORPHOLOGY IN MUSCLE SENSORIMOTOR FUNCTIONS DURING LOCOMOTION IN THE CAT DOI
Seyed Mohammadali Rahmati, Alexander N. Klishko,

Ramaldo S. Martin

и другие.

Опубликована: Июль 16, 2024

Previous studies established strong links between morphological characteristics of mammalian hindlimb muscles and their sensorimotor functions during locomotion. Less is known about the role forelimb morphology in motor outputs generation sensory signals. Here, we measured 46 from 6 cats. These included muscle attachments, physiological cross-sectional area (PCSA), fascicle length, etc. We also recorded full-body mechanics EMG activity level overground treadmill locomotion 7 16 adult cats either sex, respectively. computed forces along with force- length-dependent signals mapped onto corresponding cervical spinal segments. found that patterns afferent activities were strongly affected by muscle's moment arm, PCSA, length. Morphology shoulder suggests distinct roles forelimbs lateral force production movements. Patterns long fibers (brachioradialis, extensor carpi radialis) closely matched overall whereas pattern biceps brachii orientation. conclude cat contributes substantially to locomotor function, particularly control stability turning, rather than propulsion.

Язык: Английский

Процитировано

0
EFFECTS OF SPINAL TRANSECTION AND LOCOMOTOR SPEED ON MUSCLE SYNERGIES OF THE CAT HINDLIMB DOI Creative Commons
Alexander N. Klishko,

Jonathan Harnie,

Claire E. Hanson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 20, 2024

Abstract It was suggested that during locomotion, the nervous system controls movement by activating groups of muscles, or muscle synergies. Analysis synergies can reveal organization spinal locomotor networks and how it depends on state system, such as before after cord injury, different conditions, including a change in speed. The goal this study to investigate effects transection speed hindlimb their time-dependent activity patterns adult cats. EMG activities 15 muscles were recorded 9 cats either sex tied-belt treadmill locomotion at speeds 0.4, 0.7, 1.0 m/s recovery from low thoracic transection. We determined burst using cluster analysis onset offset times non-negative matrix factorization. found five major each six experimental conditions (2 states x 3 speeds). In case, accounted for least 90% variance. Both modified subgroups composition activation selected However, these changes did not modify general Based obtained results, we propose an pattern formation network two-level central generator be tested neuromechanical simulations circuits controlling cat locomotion.

Язык: Английский

Процитировано

0
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection DOI Creative Commons
Ilya A. Rybak, Natalia A. Shevtsova, Johannie Audet

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 14, 2024

Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following cord injury. The thoracic lateral hemisection represents an experimental model of incomplete injury, where connections between brain abolished on one side cord. To investigate effects such injury operation locomotor network, we used our computational cat locomotion recently published in

Язык: Английский

Процитировано

0
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection DOI Open Access
Ilya A. Rybak, Natalia A. Shevtsova, Johannie Audet

и другие.

eLife, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following cord injury. The thoracic lateral hemisection represents an experimental model of incomplete injury, where connections between brain abolished on one side cord. To investigate effects such injury operation locomotor network, we used our computational cat locomotion recently published in eLife (Rybak et al., 2024) to predict changes cycle phase durations a during treadmill tied-belt (equal left-right speeds) split-belt (unequal conditions. In simulations, “hemisection” was always applied right side. Based model, hypothesized hemisection, contralesional (“intact”, left) network mostly drives, whereas ipsilesional (“hemisected”, right) somatosensory feedback. We then compared simulated results those obtained experiments adult cats before after mid-thoracic same Our confirmed many predicted simulations. show having hindlimb step slow belt, but not fast substantially reduces hemisection. provides explanations for temporal characteristics based altered circuits,

Язык: Английский

Процитировано

0
Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat DOI Creative Commons
Seyed Mohammadali Rahmati, Alexander N. Klishko,

Ramaldo S. Martin

и другие.

The Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract Previous studies established strong links between morphological characteristics of mammalian hindlimb muscles and their sensorimotor functions during locomotion. Less is known about the role forelimb morphology in motor outputs generation sensory signals. Here, we measured 46 from six cats. These included muscle attachments, physiological cross‐sectional area (PCSA) fascicle length. We also recorded full‐body mechanics EMG activity level overground treadmill locomotion seven 16 adult cats either sex, respectively. computed forces along with force‐ length‐dependent signals mapped onto corresponding cervical spinal segments. found that patterns afferent activities were strongly affected by muscle's moment arm, PCSA Morphology shoulder suggests distinct roles forelimbs lateral force production movements. Patterns long fibres (brachioradialis, extensor carpi radialis) closely matched overall length, whereas pattern biceps brachii length afferents orientation. conclude cat contributes substantially to locomotor function, particularly control stability turning, rather than propulsion. image Key points Little producing generating somatosensory This information needed understand contributions control. forelimbs, walking electromyographic activity, arms, velocity, activation, muscles, as well length‐ force‐dependent walking. demonstrated contribute proprioceptive regulation cycle phase transitions stability. The obtained can guide development biologically accurate neuromechanical models quadrupedal for exploring testing novel methods treatments central nervous system pathologies modulating neural pathways controlling forelimbs/arms.

Язык: Английский

Процитировано

0