Antiviral Activity of Water–Alcoholic Extract of Cistus incanus L.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 947 - 947
Опубликована: Янв. 23, 2025
Recently,
previously
known
viruses
have
changed
their
pathogenicity
and
encompassed
new
types
of
host
populations.
An
example
such
an
infection
is
that
caused
by
SARS-CoV,
belonging
to
the
“well-known”
coronavirus
family.
Another
group
are
great
importance
human
population
herpes
viruses.
Due
increasing
viral
resistance
existing
antiviral
drugs,
plant
extracts
attracting
interest
due
complex
composition
simultaneous
attack
different
targets.
Based
on
above,
we
tested
potential
water–alcoholic
extract
obtained
from
a
commercial
sample
Cistus
incanus
L.
against
enveloped
SvHA1,
SvHA2
(ACV
resistant)
HCoV
229E.
The
results
showed
both
complete
inhibition
intracellular
stages
replication
strong
effect
extracellular
virions
in
three
models.
In
study
SvHA
2,
calculated
selectivity
index
was
over
10.
From
experiments
virucidal
effects
two
viruses,
it
found
titer
samples
decreased
about
4
lg
compared
control
sample.
for
introduction
into
practice.
Язык: Английский
Phytomedical Properties of Carica papaya for Boosting Human Immunity Against Viral Infections
Viruses,
Год журнала:
2025,
Номер
17(2), С. 271 - 271
Опубликована: Фев. 16, 2025
Carica
papaya,
a
tropical
fruit-bearing
plant,
has
attracted
significant
attention
for
its
diverse
phytomedical
properties
and
ability
to
regulate
both
innate
adaptive
immunity,
making
it
promising
natural
therapeutic
agent.
C.
papaya
is
rich
in
bioactive
compounds
that
play
multifaceted
role
immunomodulation.
These
constituents
have
demonstrated
efficacy
not
only
against
the
dengue
virus
but
also
other
viral
infections,
including
COVID-19
(Corona
Virus
Disease
2019),
Human
Immunodeficiency
(HIV),
Zika
virus,
others.
The
antiviral
effects
of
are
achieved
through
enhance
host
mitigate
inflammation,
reduce
oxidative
stress,
inhibit
replication,
modulate
immune
responses.
mechanisms
highlight
potential
as
candidate
therapies,
paving
way
further
exploration
pharmacological
applications
promoting
eco-friendly,
accessible
healthcare
solutions
combating
diseases.
This
review
highlights
extracts
inhibiting
replication
modulating
responses,
emphasizing
need
studies
clinical
trials
validate
their
medically
viruses
causing
human
Язык: Английский
Potential Benefits of In Silico Methods: A Promising Alternative in Natural Compound’s Drug Discovery and Repurposing for HBV Therapy
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 419 - 419
Опубликована: Март 16, 2025
Hepatitis
B
virus
(HBV)
is
an
important
global
public
health
issue.
The
World
Health
Organization
(WHO)
2024
Global
Report
estimated
that
the
prevalence
of
people
living
with
HBV
infection
254
million,
incidence
1.2
million
new
infections
yearly.
Previous
studies
have
shown
natural
compounds
antiviral
inhibition
potentials.
In
silico
methods
such
as
molecular
docking,
virtual
screening,
pharmacophore
modeling,
quantitative
structure–activity
relationship
(QSAR),
and
dynamic
simulations
been
successfully
applied
in
identifying
bioactive
strong
binding
energies
treatment
targets.
COVID-19
pandemic
necessitated
importance
repurposing
already
approved
drugs
using
methods.
This
study
aimed
at
unveiling
benefits
techniques
a
potential
alternative
compounds’
drug
discovery
for
therapy.
Relevant
articles
from
PubMed,
Google
Scholar,
Web
Science
were
retrieved
analyzed.
Furthermore,
this
comprehensively
reviewed
literature
containing
identified
essential
proteins.
Notably,
hesperidin,
quercetin,
kaempferol,
myricetin,
flavonoids
hepatitis
surface
antigen
(HBsAg).
investigation
reveals
offer
understanding
mechanisms
action,
reveal
previously
overlooked
viral
targets
(including
PreS1
Domain
HBsAg
cccDNA
(Covalently
Closed
Circular
DNA)
regulators,
facilitate
creation
specific
inhibitors.
integration
silico,
vitro,
vivo
insights
further
highlight
Moreover,
combination
compounds,
approach,
improves
chances
personalized
precision
medicine
treatment.
Therefore,
we
recommend
strategies
combine
vivo,
approaches
to
effective
drugs.
Язык: Английский