The association between dietary intake of flavonoids and its subclasses and the risk of metabolic syndrome

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июль 5, 2023

The healthiest way to prevent metabolic syndrome (MetS) is through behavioral and nutritional adjustments. We examined the relationship between total flavonoids intake, flavonoid subclasses, clinically manifest MetS.A cross-sectional analysis was conducted among 28,719 individuals from National Health Nutrition Examination Survey (NHANES) Food Nutrient Database for Dietary Studies (FNDDS) 2007-2011 2017-2018. Two 24-h reviews were determine intake subclasses. link MetS investigated using a multivariate logistic regression model.Q2 Q3 of associated with 20 19% lower risk incident after adjusting age sex. Anthocyanidins flavanones in Q2 substantially reduced compared Q1. decreased steadily as increased 237.67 mg/d. Flavanones anthocyanidins also displayed V-shaped curves (34.37 23.13 mg/d).MetS adversely linked flavanones, anthocyanidins. Moreover, most effective doses flavonoids, 237.67, 34.37, mg/d, respectively, potentially preventing MetS.

Язык: Английский

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Intake of dietary flavonoids in relation to bone loss among U.S. adults: a promising strategy for improving bone health

Food & Function, Год журнала: 2023, Номер 15(2), С. 766 - 778

Опубликована: Дек. 8, 2023

The intake of three flavonoid subclasses (flavones, flavanones, and isoflavones) is beneficially associated with bone health in the US adult population.

Язык: Английский

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Association of composite dietary antioxidant index and muscle mass in individuals with metabolic associated fatty liver disease

Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2024, Номер 48(2), С. 102284 - 102284

Опубликована: Янв. 15, 2024

Язык: Английский

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The association between flavonoids intake and hypertension in U.S. adults: A cross‐sectional study from The National Health and Nutrition Examination Survey

Journal of Clinical Hypertension, Год журнала: 2024, Номер 26(5), С. 573 - 583

Опубликована: Апрель 17, 2024

Abstract Although in vitro experiments have demonstrated the potential of flavonoid compounds regulating blood pressure, there is still a lack evidence from large population studies. We conducted cross‐sectional study using National Health and Nutrition Examination Survey to investigate relationship between intake levels (natural log transformation) hypertension events. A total 15 752 participants aged over 20 years were included, weighted multivariable logistic regression analysis was performed explore flavonoids, five sub types intake, Smooth curve fitting used nonlinear relationships. Higher flavonoids associated with lower risk than lowest group. The adjusted odds ratios (95% CIs) 0.79 (0.70–0.88) for intake. Elevated significantly linearly hypertension. For each unit increase level, ORs decrease by 5% (OR 0.95; 95% CI, 0.92–0.98). In addition, restricted cubic spline regression, we found that flavan‐3‐ols, anthocyanidins, flavonols negatively related prevalence Flavones showed associations inflection points ‐1.90. Within certain range, negative correlation exists This finding provides insights into dietary modifications prevention

Язык: Английский

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Associations of the Intake of Individual and Multiple Flavonoids with Metabolic Dysfunction Associated Steatotic Liver Disease in the United States

Nutrients, Год журнала: 2025, Номер 17(2), С. 205 - 205

Опубликована: Янв. 7, 2025

Evidence regarding the individual and combined impact of dietary flavonoids on risk metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate association between multiple MASLD in adults. Data sets were obtained from National Health Nutrition Examination Survey (NHANES), 2017-2018. In total, 2581 participants aged over 18 years, complete information flavonoid intake, MASLD, covariates, included. Flavonoid intake was energy-adjusted using residual method. Logistic regression analysis employed examine total MASLD. Weighted quantile sum (WQS) analyses used effects identify predominant types most significant contribution prevention. The highest tertile a 29% reduction compared lowest after multivariable adjustments (OR: 0.71, 95% CI: 0.51-0.97). WQS revealed that anthocyanidins, flavones, flavanones critical contributors among six subclasses (weights = 0.317, 0.279, 0.227, respectively) naringenin, apigenin, delphinidin 29 monomers. 0.240, 0.231, 0.114, respectively). Also, higher linked reduced (p < 0.05). findings suggested lower flavanones, delphinidin, myricetin contributing protective flavonoids.

Язык: Английский

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Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Апрель 2, 2024

Introduction The primary treatment for non-alcoholic fatty liver disease (NAFLD) is modifying lifestyle through dietary or exercise interventions. In recent decades, it has received increasing attention. However, the lack of bibliometric analysis posed a challenge researchers seeking to understand overall trends in this field. Methods As February 3rd, 2024, 876 articles on treating NAFLD diet therapy from 2013 2023 had been retrieved. Two software tools, VOSviewer and CiteSpace, were utilized analyze growth publications, countries, institutions, authors, journals, citations, keywords. Additionally, keywords with strong citation burstiness identified determine changes future research hotspots Results China highest number articles, followed by United States South Korea. Yonsei University Nutrient s institutions journals most significant contributions. Professor Younossi Zobair M, States, prolific author Through analyzing keywords, three identified: pathogenesis NAFLD, modalities risk factors diagnosis methods NAFLD. years, emphasis field changed, suggesting that will focus two frontier keywords: “oxidative stress” “aerobic capacity.” Conclusion past eleven attention was still rising, countries so formed considerable cooperative relationship. There also many highly influential productive It speculated new continue around exercise” future.

Язык: Английский

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Association between consumption of flavonol and its subclasses and chronic kidney disease in US adults: an analysis based on National Health and Nutrition Examination Survey data from 2007–2008, 2009–2010, and 2017–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 18, 2024

Background There is little research on the relationship between flavonol consumption and chronic kidney disease (CKD). This study aimed to examine link risk of CKD among US adults, using data from 2007–2008, 2009–2010 2017–2018 National Health Nutrition Examination Survey (NHANES). Methods A cross-sectional approach was used, drawing three NHANES cycles. The participants in this assessed a 48 h dietary recall interview. diagnosed based an estimated glomerular filtration rate below 60 mL/min/1.73 m 2 or urine albumin-to-creatinine ratio 30 mg/g higher. Results Compared lowest quartile intake (Q1), odds ratios for were 0.598 (95% CI: 0.349, 1.023) second (Q2), 0.679 0.404, 1.142) third (Q3), 0.628 0.395, 0.998) fourth (Q4), with p value trend significance 0.190. In addition, there significant isorhamnetin intake, decreasing 0.860 0.546, 1.354) quartile, 0.778 0.515, 1.177) 0.637 ( = 0.013). Conclusion Our analysis spanning 2009–2010, suggests that high flavonol, especially isorhamnetin, might be linked lower adults. These findings offer new avenues exploring strategies managing CKD.

Язык: Английский

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Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study

European Journal of Gastroenterology & Hepatology, Год журнала: 2023, Номер 36(2), С. 210 - 219

Опубликована: Ноя. 30, 2023

Objective The possible interaction of dietary flavonoid intake and sleep on non-alcoholic fatty liver disease (NAFLD) has not been well studied. This study investigated the between trouble sleeping risk NAFLD. Methods Three discrete National Health Nutrition Examination Survey data cycles from 2007 to 2010 2017 2018 were used. NAFLD was diagnosed by a US Fatty Liver Index ≥30. A questionnaire sleeping. Univariate multivariate logistic regression, restricted cubic spline (RCS) subgroup analyses used evaluate association flavonoids, We employed relative excess due interaction, attributable proportion synergy index additive interactions. Results Ultimately, 5056 participants enrolled, higher anthocyanidins flavanones negatively correlated with Conversely, positively associated These correlations remained stable after adjusting for confounders, there sex difference in this relationship. In RCS model, anthocyanins non-linearly related NAFLD, while showed negative linear Moreover, synergistic interplay low anthocyanin similar relationship existed flavanone intake. Conclusion Anthocyanin associated, whereas risk. There effect same

Язык: Английский

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Association between dietary intake of flavonoid and chronic kidney disease in US adults: Evidence from NHANES 2007-2008, 2009-2010, and 2017-2018

PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0309026 - e0309026

Опубликована: Авг. 27, 2024

Background Studies investigating the relationship between flavonoid intake and chronic kidney disease (CKD) are limited. This study investigated association daily CKD in US adults by using data for 2007–2008, 2009–2010, 2017–2018 from National Health Nutrition Examination Survey (NHANES) database. Methods employed a cross-sectional design used three cycles of continuous NHANES: 2017–2018. NHANES researchers collected related to consumption various food beverages participants employing 24-h dietary recall questionnaires. is defined as an estimated glomerular filtration rate < 60 mL/min/1.73m 2 or urine albumin-to-creatinine ratio ≥ 30 mg/g. Results The odds ratios (OR) risk second (Q2), third (Q3), fourth (Q4) quartiles total intake, compared with that first (Q1) quartile, were 0.780 (95% CI: 0.600, 1.015), 0.741 0.573, 0.957), 0.716 0.554, 0.925), respectively (with P value trend 0.040). According restricted cubic spline analysis, exhibited non-linear (P 0.001). Conclusion Our findings suggest potential J-shaped was observed risk, inflection point at 69.58 mg/d. indicates moderate flavonoids may confer renal benefits which offer novel strategies treatment.

Язык: Английский

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Flavonoids and Their Role in Preventing the Development and Progression of MAFLD by Modifying the Microbiota

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11187 - 11187

Опубликована: Окт. 17, 2024

With the increasing prevalence and serious health consequences of metabolic-associated fatty liver disease (MAFLD), early diagnosis intervention are key to effective treatment. Recent studies highlight important role dietary factors, including use flavonoids, in improving health. These compounds possess anti-inflammatory, antioxidant, liver-protective properties. Flavonoids have been shown affect gut microbiota, which plays a function progression. Therefore, their preventing development progression MAFLD through modulation microbiome seems be interest. This narrative review aims consolidate current evidence on effects selected flavonoids progression, potential mechanisms action, implications for personalized interventions management disease.

Язык: Английский

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