Modern
lifestyle
and
diet
have
increased
the
incidence
rate
of
uric
acid
(UA)
metabolism-related
diseases
like
hyperuricemia
(HUA)
gout,
posing
heavy
economic
burden
to
individual
patients
their
families
society.
Uric
metabolism
is
a
complex
physiological
process
involving
kidney,
intestine,
other
organs.
A
number
factors
together
regulate
UA
metabolism,
including
genetics,
diet,
hormones,
gut
microbiota.
This
review
summaries
microbiota
features
in
subjects
with
HUA
therapeutic
effects
implementing
microecological
therapies
(probiotics,
prebiotics,
or
fecal
transplant)
that
target
modulate
its
downstream
on
disease.
Current
evidence
shows
these
strategies
are
safe
promising
alleviate
inflammation,
reduce
UA,
restoring
healthy
diseases.
However,
most
clinical
data
generated
by
animal
studies.
Therefore,
we
propose
vigorous
human
intervention
trials
should
be
conducted
future
evaluate
managing
gout.
Foods,
Год журнала:
2025,
Номер
14(7), С. 1118 - 1118
Опубликована: Март 24, 2025
This
study
investigated
the
protective
effects
of
a
polyherbal
tea
(PHT)
on
intestinal
injury
in
hyperuricemia
(HUA)
mice
and
underlying
mechanisms.
PHT
was
orally
administered
to
for
49
days,
while
potassium
oxonate
hypoxanthine
were
7
days
after
administration
continued
42
cause
HUA.
Treatment
with
significantly
reduced
serum
uric
acid
blood
urea
nitrogen
levels
HUA
mice.
It
also
inhibited
liver
xanthine
oxidase
activity
promoted
excretion
through
upregulation
transporters
GLUT9
ABCG2.
Intestinal
barrier
integrity
reinforced,
as
evidenced
by
restoration
villous
structure,
reduction
edema,
tight
junction
proteins
(occludin,
ZO-1)
mucin
(MUC2).
Moreover,
suppressed
LPS
NF-κB
pathway,
leading
TNF-α
IL-6
gut.
Gut
microbiota
analysis
revealed
reversed
dysbiosis,
enriching
beneficial
bacteria
like
Duncaniella
sp.
Heminiphilus
faecis.
By
UPLC-MS
analysis,
154
compounds
persisted
gut,
suggesting
that
these
are
likely
modulate
both
function
gut
microbiota.
These
findings
suggest
this
may
have
potential
functional
food
prevention
hyperuricemia.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14462 - 14462
Опубликована: Сен. 23, 2023
Both
inosine
and
guanosine
are
precursors
of
uric
acid
that
may
cause
the
diseases
hyperuricemia
gout
in
humans.
Here,
a
promising
bacterial
strain
for
efficiently
biodegrading
both
was
successfully
isolated
from
healthy
human
intestine
identified
as
Bacillus
paranthracis
YD01
with
16S
rRNA
analysis.
An
initial
amount
49.6
mg·L−1
or
49.9
completely
removed
by
within
12
h,
which
showed
had
strong
ability
to
biodegrade
guanosine.
Furthermore,
49.2
49.5
totally
catalyzed
intracellular
crude
enzymes
6
49.7
biodegraded
extracellular
9
h.
Illumina
Hiseq
sequencing
database
gene
annotation
were
used
elucidate
genomic
characteristics
B.
YD01.
Purine
nucleoside
phosphorylase,
encoded
1785,
3933,
4403,
found
KEEG
database,
played
crucial
role
biodegradation
The
results
this
study
provide
valuable
insights
into
mechanisms
using
Expert Opinion on Therapeutic Targets,
Год журнала:
2023,
Номер
27(8), С. 679 - 703
Опубликована: Авг. 3, 2023
Introduction
Gout
arthritis
(GA)
is
an
intermittent
inflammatory
disease
affecting
approximately
10%
of
the
worldwide
population.
Symptomatic
phases
(acute
flares)
are
timely
spaced
by
asymptomatic
periods.
During
acute
attack,
redness,
joint
swelling,
limited
movement,
and
excruciating
pain
common
symptoms.
However,
current
available
therapies
not
fully
effective
in
reducing
symptoms
offer
numerous
side
effects.
Therefore,
unveiling
new
drug
targets
effector
molecules
required
developing
novel
GA
therapeutics.
Microorganisms,
Год журнала:
2024,
Номер
12(4), С. 832 - 832
Опубликована: Апрель 20, 2024
Pickled
cabbage,
a
traditional
fermented
food
rich
in
functional
microorganisms,
can
effectively
control
hyperuricemia
and
gout.
In
this
study,
Priestia
megaterium
ASC-1
strain
with
strong
uric
acid
(UA)
degradation
ability
was
isolated
from
pickled
cabbage.
After
oral
administration
for
15
days,
stably
colonized
the
rats
study.
significantly
reduced
UA
levels
(67.24%)
hyperuricemic
rats.
Additionally,
alleviated
hyperuricemia-related
inflammatory
response,
oxidative
stress,
blood
urea
nitrogen.
Intestinal
microbial
diversity
results
showed
that
restored
intestinal
injury
gut
flora
dysbiosis
caused
by
hyperuricemia.
These
findings
suggest
P.
may
be
used
as
therapeutic
adjuvant
treatment
of
Modern
lifestyle
and
diet
have
increased
the
incidence
rate
of
uric
acid
(UA)
metabolism-related
diseases
like
hyperuricemia
(HUA)
gout,
posing
heavy
economic
burden
to
individual
patients
their
families
society.
Uric
metabolism
is
a
complex
physiological
process
involving
kidney,
intestine,
other
organs.
A
number
factors
together
regulate
UA
metabolism,
including
genetics,
diet,
hormones,
gut
microbiota.
This
review
summaries
microbiota
features
in
subjects
with
HUA
therapeutic
effects
implementing
microecological
therapies
(probiotics,
prebiotics,
or
fecal
transplant)
that
target
modulate
its
downstream
on
disease.
Current
evidence
shows
these
strategies
are
safe
promising
alleviate
inflammation,
reduce
UA,
restoring
healthy
diseases.
However,
most
clinical
data
generated
by
animal
studies.
Therefore,
we
propose
vigorous
human
intervention
trials
should
be
conducted
future
evaluate
managing
gout.
