Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Май 17, 2024
Язык: Английский
Advanced Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.
Язык: Английский
Процитировано
0
BMC Gastroenterology, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 3, 2025
Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows promise in UC animal models, but systematic review needed. A search was conducted across databases including PubMed, EBSCO, Web Science, Science Direct, up to March 2024, identifying randomized controlled trials (RCTs) examining baicalin's impact on models. Seventeen studies were selected through manual screening. Meta-analyses subgroup analyses utilized Rev Man 5.3 Stata 15.0 software assess symptom improvement. From 1304 citations, 17 analyzed. significantly modulated various biomarkers: HCS (SMD = -3.91), DAI (MD -2.75), spleen index -12.76), MDA -3.88), IL-6 -10.59), IL-1β -3.98), TNF-α -8.05), NF-κB -5.46), TLR4 -0.38), RORγ -0.89), MCP-1 -153.25), MPO -7.34), Caspase-9 -0.93), Caspase-3 -0.45), FasL -1.20)) enhanced BWC 0.06), CL 1.39), ZO-1 0.44), SOD 3.04), IL-10 mRNA 3.14), FOXP3 0.45) levels. Baicalin's actions may involve the PI3K/AKT, TLR4/NF-κB, IKK/IKB, Bcl-2/Bax, Th17/Treg, TLRs/MyD88 pathways. Optimal outcomes predicted at dosages 60–150 mg/kg over 10–14 weeks. demonstrates multifaceted potential UC, attributed its anti-inflammatory, antioxidant, anti-apoptotic, intestinal barrier repair properties. While higher doses longer appear beneficial, further research, particularly human clinical trials, necessary verify effectiveness safety people.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер 94, С. 102791 - 102791
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 5(1), С. 38 - 48
Опубликована: Март 17, 2025
Ülseratif kolit, kolonun mukozal ve submukozal tabakalarının kronik inflamasyonuyla seyreden bir hastalıktır. Kolon inflamasyonu, immün sistem hücrelerinin aşırı aktivasyonuna yol açarak reaktif oksijen nitrojen türevlerinin salınmasına oksidatif strese sebep olmaktadır. Çalışmamızda, ratlarda asetik asitle oluşturulmuş kolit modelinin serum kolon dokusu NOD benzeri reseptör proteini 3 (NLRP3) ile süperoksit dismutaz (SOD) düzeyleri üzerine etkileri araştırılmıştır. Ayrıca, güçlü antioksidan olan alfa lipoik asitin bu parametreler düzenleyici etkilerinin araştırılması da amaçlanmıştır. Araştırmamızda, 8-10 haftalık 200-250 g ağırlığında sağlıklı 34 adet erkek Wistar Albino ırkı sıçan kullanıldı. Hayvanlar kontrol grubunda 6, deney gruplarında 7 hayvan olacak şekilde 5 gruba ayrıldı. Kontrol grubu dışındaki hayvanlara indüksiyonu amacıyla %4 asit intrarektal olarak uygulandı. Daha sonra asit, mesalamin her ikisinin birlikte kullanılmasıyla tedaviye başlandı 14 gün süreyle devam edildi. Tedavi prosedürü boyunca hayvanların diyare skorları kaydedildi. Deney sonrası sıçanların dokularındaki NLRP3 seviyeleri SOD değerlendirildi. Diyare skorunun diğer gruplara göre anlamlı yükseldiği; mesalamin+alfa ise azaldığı saptandı. Kolit grubunda, seviyesinin en yüksek, düşük seviyede olduğu belirlendi. Mesalamin+alfa parametrelerin düzenlendiği görüldü. Sonuç olarak, olgularında inflamazomunun arttığı, düzeyinin azaldığı; kombinasyonun değerler tek başına kullanımına daha iyi kanaatine varıldı.
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 461 - 461
Опубликована: Март 25, 2025
Background: Inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease, affect the gastrointestinal tract. Treatment aims to induce remission relieve symptoms but may fail or cause side effects. Recent studies suggest that natural polysaccharides can reduce inflammation promote healing. The of pulp tamarillo (Solanum betaceum cav.) have shown beneficial effects, their potential in is still unexplored. Objective: To investigate effect from an animal model colitis. Methods: Polysaccharides (STWA) were extracted tested female mice (BALB/c) on dextran sodium sulfate (DSS)-induced Different doses (10 mg/kg, 30 100 mg/kg). course disease weight animals monitored daily. At end experimental protocol, large intestine was removed measured. Markers oxidative stress then analyzed. Histological analysis performed assess microscopic changes. Results: with STWA (100 mg/kg) prevented loss DSS-induced reduced activity index. colon length preserved, occult blood feces reduced. controlled stress. Glutathione S-transferase (GST) levels increased, while lipid peroxidation decreased. inflammatory process reduced, indicated by decrease myeloperoxidase (MPO), N-acetylglucosamine (NAG), tumor necrosis factor alpha (TNF-α) increase interleukin 10 (IL-10) levels. also improved histology, preserving colonic epithelium. Conclusions: results has protective reduces mice.
Язык: Английский
Процитировано
0
Nucleosides Nucleotides & Nucleic Acids, Год журнала: 2025, Номер unknown, С. 1 - 11
Опубликована: Март 25, 2025
Ulcerative colitis (UC) is a chronic condition characterized by inflammation in the colon. Free radicals and oxidative stress play significant role pathophysiology of UC. Excessive production reactive oxygen species can damage mitochondrial genome, leading to mutations such as the7436-bp deletion. The aim this study was identify presence 7436-bp mtDNA deletion patients with UC its association susceptibility colon inflammation. This case-control study, included 195 250 healthy individuals from Iranian population. Multiplex PCR method used detect Statistical analysis performed using SPSS software. frequency 41.5% 6.8% individuals. showed between (p = 0.016). Furthermore, difference found an increased risk severe 0.003) extensive 0.002) forms There no statistically younger control group. suggests that factor for plays pathogenesis disease. Further research involving larger more diverse populations necessary validate or challenge these findings. Identifying enhance our understanding genetic factors influencing
Язык: Английский
Процитировано
0
Pharmacological Reports, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
Preventive Nutrition and Food Science, Год журнала: 2025, Номер 30(2), С. 101 - 109
Опубликована: Апрель 29, 2025
Among organ transplant operations, liver transplantation (LTX) has one of the highest risks postoperative infection. This study aimed to systematically review current evidence on use probiotics and synbiotics in reducing incidence infections recipients. A systematic search was performed identify studies that investigated role infection rates Eight qualified were included review. The results showed effectively reduced overall patients compared with placebo or control groups. positive effect might be attributed improved intestinal barrier function, gut microbiota restoration, decreased inflammation. Furthermore, probiotic treatment associated shorter durations antibiotic hospital stays. after LTX holds promise decreasing providing substantial advantages for patients. Probiotics have been shown boost levels beneficial bacterial, decrease inflammation, fortify barrier, lessen oxidative stress, improve generation anti-inflammatory short-chain fatty acids. However, more extensive research is needed most effective strains evaluate their effectiveness this specific patient demographic.
Язык: Английский
Процитировано
0
BioNanoScience, Год журнала: 2025, Номер 15(3)
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0
Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 28, 2023
Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles gut physiology pathophysiology due to its permeability water, glycerol hydrogen peroxide. In this review, we systematically summarized current understanding of expression AQP3 intestine different species, focused on potential transport, types diarrhea constipation, intestinal inflammation, barrier function, oxidative stress, autophagy. These updated findings have supported that may function as an target maintaining health human animals.
Язык: Английский
Процитировано
9