Relationship between Life’s Essential 8 and metabolic syndrome among older Americans (NHANES, 2007–2010): navigating biological aging and inflammation

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Июнь 5, 2024

Background Metabolic syndrome (MetS) is a global health concern, and it particularly harmful to middle-aged elderly individuals. Life Element Eight (LE8), measure improve cardiovascular health, may offer benefits for MetS. Herein, we examined the relationship between LE8 MetS among individuals, elucidated role of biological aging inflammation in this process. Methods We obtained scores 2,901 Americans, along with their indicators (Biological age, Phenotypic Serum Klotho), computed inflammatory SII, DII. Using logistic regression model, assessed association markers, Biological aging, Additionally, generated restricted cubic spline (RCS) plots display trends significant variables regression. parallel mediation analysis, evaluated possible mediating various factors risk Results Our examination revealed that higher were associated lower incidence fully adjusted model. The high subgroup had 79.73% reduction compared low an OR = 0.2027 (95% Cl 0.0871, 0.4714), similar correlations factor risk. mediated associations LE8, behaviors Conclusion A rise score individuals protective MetS, be partially by suggesting reduce ameliorating aging.

Язык: Английский

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Association between prebiotic, probiotic consumption and hyperuricemia in U.S. adults: a cross-sectional study from NHANES 2011–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 14, 2025

This study aims to provide evidence for an association between the consumption of prebiotics and probiotics hyperuricemia in U.S. adults. A total 7,176 adults who participated National Health Nutrition Examination Survey (NHANES) during 2011-2018 were included study. First, baseline characteristics data described weighted data, using presence or absence as classification criterion. Second, binary logistic regression analyses performed establish crude models adjusted relevant covariates, odds ratios (OR) 95% confidence intervals (95% CI) calculated explore relationship prebiotics, probiotic intake, hyperuricemia. Subsequently, receiver operating characteristic (ROC) curves plotted assess consumption's role prediction model. Finally, subgroup performed. Participants consumed had a lower prevalence than those did not (3.48% vs. 6.25%, p = 0.082). In analyses, prebiotics' effect on was insignificant (p > 0.05), regardless whether covariates considered. contrast, model 1, which constructed by adjusting age, sex, ethnicity, showed ORs less 1 (crude model: OR 0.54, CI [0.34, 0.83], 0.008; 1: 0.008). The predictive model, including race, body mass index (BMI), hypertension, chronic kidney disease, probiotics, 76.7% sensitivity 68.0% specificity with area under ROC curve 0.7886 detecting US These results suggest that may reduce incidence adult population, but have shown same effect.

Язык: Английский

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The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 10, 2025

Despite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between Metabolic Score Visceral Fat (METS-VF) and HUA remain insufficient. This research focused METS-VF's potential role as a HUA. Notably, 8,659 participants from National Health Nutrition Examination Survey (NHANES) 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup interaction test, restricted cubic spline (RCS) analysis implemented identify correlation METS-VF In fully adjusted model, results of multiple indicated was related elevated prevalence [before PSM: odds ratio (OR) = 3.51 (2.88, 4.27), p < 0.001; after OR 2.90 (2.36, 3.58), 0.001]. RCS non-linear positive observed incidence (before p-non-linear <0.001; 0.0065). Subgroup tests revealed impact modified by sex ethnicity. There significant adults United States. could serve valuable metric assessing development progression

Язык: Английский

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Association of hyperuricemia with dietary patterns and alcohol consumption in the adult population. Results of the ESSE-RF epidemiological study

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2025, Номер 23(12), С. 4160 - 4160

Опубликована: Фев. 11, 2025

Aim. To study the associations of hyperuricemia (HU) with dietary patterns and alcohol consumption in Russian population. Material methods . Representative samples male female population aged 25-64 years (17929 people, including 6593 men 11336 women) from 13 regions were examined. The response rate was ~80%. pattern studied by main food groups. HU diagnosed at a uric acid (UA) level >400 μmol/l for >360 women. results are presented as odds ratio (OR) 95% confidence interval (CI). Results. People more often consume fish (men 28% women 34%) (p<0,005), less — sweets (by 22 21%, respectively) (p<0,001) cheese 14%, (p<0,05). In diet individuals HU, excess sugar is lower 19 23% women, respectively (p<0,001). Women also have 13% red meat consumption, 36% legume higher poultry 25% low-fat dairy products (p<0,05), well 15% animal fat use cooking (p=0,008) compared to without HU. Individuals do not discontinue alcohol, but its than men, amount consumed has linear association UA risk. general, among consumers, risk 1,32 [1,13-1,54] (p=0,001). low 1,24 [1,05-1,45] (p=0,009), moderate high 1,61 [1,32-1,97] 1,64 [1,27-2,12] (p<0,001), respectively. Conclusion differs significantly which pronounced increases linearly consumed.

Язык: Английский

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Associations Between Folate Intake, Serum Folate, and Stroke Risk: The Mediating Role of Dietary Inflammatory Index from NHANES 2007-2018

Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2025, Номер unknown, С. 108318 - 108318

Опубликована: Апрель 1, 2025

Язык: Английский

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Association of dietary saturated fatty acid intake with depression: mediating effects of the dietary inflammation index

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 14, 2024

Background Diet and dietary inflammation play an important role in depression. The aim of this study was to assess the association SFAs with depression risk mediating DII. Method Among 22, 478 U.S. adults (≥ 20, years old) according National Health Nutrition Examination Survey (NHANES), univariate logistic regression, multivariate regression were used evaluate between intake Dietary levels evaluated using Mediation analysis investigate DII nonlinear relationship assessed restricted cubic spline (RCS). Results There a significant difference SFA 6.0 non-depression individuals. After adjusting for potential confounders, multifactorial results showed that 8.0 (Q3 1.58 (1.09, 2.30), p -value = 0.017; Q4 1.55 (1.00, 2.42), 0.050) may increase prevalence factor depression, 14.0 0.67 (0.47, 0.94), 0.020) decrease sex age differences effects different subtypes on 12.0 content ( 0.005). Furthermore, recognized as mediator Conclusion findings suggest is associated relation chain length SFAs, be due effect

Язык: Английский

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Pro-inflammatory diets promote the formation of hyperuricemia

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июнь 21, 2024

Hyperuricemia, as a very prevalent chronic metabolic disease with increasing prevalence year by year, poses significant burden on individual patients well the global health care and burden, there is growing evidence that it associated other underlying diseases such hypertension cardiovascular disease. The association between hyperuricemia dietary inflammatory index (DII) scores was investigated in this study.

Язык: Английский

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Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018)

Arthritis Care & Research, Год журнала: 2024, Номер 76(8), С. 1179 - 1186

Опубликована: Апрель 1, 2024

This study aimed to assess the association between Dietary Inflammatory Index (DII) score and death among adults with hyperuricemia.

Язык: Английский

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Anti-Hyperuricemia Activity and Potential Mechanisms of Medicinal Mushroom Activity: A Review of Preclinical Studies

International journal of medicinal mushrooms, Год журнала: 2024, Номер 26(7), С. 1 - 12

Опубликована: Янв. 1, 2024

Hyperuricemia (HUA) is characterized by abnormally elevated levels of serum uric acid, the product purine metabolism. The primary symptom HUA gout; however, asymptomatic associated with complications such as hypertension, kidney disease, cardiovascular and metabolic syndrome. activation xanthine oxidase (XO), a pivotal enzyme in acid biosynthesis, coupled extensive reactive oxygen species generation, leading to inflammatory responses, triggers development its complications. In clinical practice, XO inhibitors are primarily used treat HUA; their prolonged use accompanied serious adverse effects. Mushrooms bioactive constituents have shown promising anti-HUA activities both <i>in vitro</i> vivo</i> studies, including inhibition urate production, modulation renal transporters, enhancement intestinal excretion, antioxidant, anti-inflammatory, antimetabolic syndrome properties. Clinical trials necessary validate beneficial effects safety mushrooms preventing or alleviating attenuating This review presents contemporary insights into pathogenesis HUA, components mushrooms, therapeutic potential, underlying mechanisms involved ameliorating HUA.

Язык: Английский

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Associations between estradiol and hyperuricemia and the mediating effects of TC, TG, and TyG: NHANES 2013–2016

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 7, 2024

To explore the relationship between estradiol (E2) and incidence of hyperuricemia (HUA) in adult women to whether glucolipid metabolism disorders play a mediating role this relationship.

Язык: Английский

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