Flavonoids and phenolic acids from sugarcane: Distribution in the plant, changes during processing, and potential benefits to industry and health

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(2)

Опубликована: Фев. 19, 2024

Abstract Sugarcane ( Saccharum sp.) plants are grown in warmer climates throughout the world and processed to produce sugar as well other useful byproducts such molasses bagasse. is rich (poly)phenols, but there has been no attempt critically evaluate published information based on use of suitable methodologies. The objective this review quantitative qualitative (poly)phenolic profiles individual parts sugarcane plant its multiple industrial products, which will help develop new processes uses for (poly)phenols. analysis involves examination extraction, concentration, analytical techniques used each study part product. indicates identification various (poly)phenols processing chain, using only compounds elucidated through robust methodologies mass spectrometry or nuclear magnetic resonance. In conclusion, predominantly flavonoids phenolic acids. main flavonoids, derivatives apigenin, luteolin, tricin, with a substantial proportion C ‐glycosides, consistently found across all phases processing. principal acids reported process include chlorogenic acids, ferulic caffeic mostly observed after hydrolysis. derivation precise publications impeded by inconsistencies presence potential benefits applications health suggests could be provider valuable future research processes.

Язык: Английский

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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Год журнала: 2024, Номер 15(2), С. 163 - 205

Опубликована: Апрель 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Язык: Английский

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Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition

Translational Cancer Research, Год журнала: 2024, Номер 13(1), С. 348 - 362

Опубликована: Янв. 1, 2024

Background: Although there are many treatments for breast cancer, such as surgery, radiotherapy, chemotherapy, estrogen receptor antagonists, immune checkpoint inhibitors and so on. However, safer more effective therapeutic drugs cancer needed. Sinensetin, a drugs, come from citrus species medicinal plants used in traditional medicine, while its role underlying mechanism remain unclear. Our study aimed to investigate the of sinensetin cancer. Methods: Cell Counting Kit-8 (CCK-8) was determine safe concentration MCF-10A, MCF7 MDA-MB-231 cells; 120 μM subsequent experiments. Real time polymerase chain reaction (RT-PCR), Western blotting, Terminal Deoxynucleotidyl Transferase mediated dUTP Nick-End Labeling (TUNEL) apoptosis assay, Transwell invasion assay Clone formation were this cell viability, mRNA expression, protein levels, apoptosis, proliferation, Results: Herein, our results showed that suppressed viability promoted cells. Treatment with µM 24 h no significant toxicity normal mammary decreased invasion, epithelial-mesenchymal transition (EMT), downregulated β-catenin, lymphatic enhancing factor 1 (LEF1), T-cell (TCF) 1/TCF7, TCF3/TCF7L1 expression The Wnt agonist SKL2001 reversed inhibitory effect on survival, metastasis, EMT. Sinensetin-induced downregulation LEF1, TCF1/TCF7 upregulated by Conclusions: In summary, metastasis via inhibition Wnt/β-catenin pathway adverse effects confirmed cells provided better understanding mechanism.

Язык: Английский

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A comprehensive review of apigenin a dietary flavonoid: biological sources, nutraceutical prospects, chemistry and pharmacological insights and health benefits

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 37

Опубликована: Авг. 17, 2024

A multitude of plant-derived bioactive compounds have shown significant promise in preventing chronic illnesses, with flavonoids constituting a substantial class naturally occurring polyphenolic compounds. Apigenin, flavone identified as 4′,5,7-trihydroxyflavone, holds immense preventative agent against illnesses. Despite its extensive research and recognized nutraceutical value, therapeutic application remains underexplored, necessitating further clinical investigations. This review delves into the biological sources, prospects, chemistry, pharmacological insights, health benefits apigenin. Through multifaceted analytical studies, we explore diverse profile potential applications across various domains. The manuscript comprehensively examines apigenin's role neuroprotective , anti-inflammatory compound, potent antioxidant agent. Additionally, efficacy combating cardiovascular diseases, anti-diabetic properties, anticancer has been discussed. Furthermore, antimicrobial attributes challenges surrounding bioavailability, particularly from herbal supplements addressed. Available forms including tablets, capsules, solid dispersions, co-crystals, inclusion complexes nano formulations. it is prevalent supplement While strides made overcoming pharmacokinetic hurdles, effectiveness bioavailability imperative for widespread utilization preventive medicine.

Язык: Английский

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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1600 - 1600

Опубликована: Окт. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Язык: Английский

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Inhibitory Effects of Bioactive Molecules against Nonstructural Protein (NSs) of Rift Valley Fever Virus (RVFv): A Molecular Modeling Study

Heliyon, Год журнала: 2025, Номер 11(6), С. e42895 - e42895

Опубликована: Фев. 21, 2025

Язык: Английский

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Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

The complex nature of osteoarthritis (OA), driven by the intricate interplay genetic, environmental, and lifestyle factors, necessitates development a single treatment method, which is highly challenging. long-term use non-steroidal anti-inflammatory drugs (NSAIDs) corticosteroids often leads to adverse side effects like kidney damage stomach ulcers. Major health threats obesity aging create milieu chronic low-grade inflammation increased mechanical stress on joints resulting in cartilage deterioration. Additionally, postmenopausal women with lower circulating 17β-estradiol levels experience accelerated joint deterioration due immune activity production pro-inflammatory cytokines, elevated MMP expression decreased type II collagen synthesis. Polyphenols are nature's gifted magic molecules, possess diverse biological properties anti-oxidant, anti-bacterial, anti-inflammatory, estrogenic, insulin-sensitizing effects, can manage treat all multi-factorial contributing factors OA effectively. Certain polyphenols act as phytoestrogens mimic natural estrogen binding ERα ERβ SERMs prevent degradation articular thereby alleviating osteoarthritic conditions. These molecules downregulate various apoptotic genes, matrix-degrading proteases (MMPs) while upregulating major ECM proteins collagen, aggrecan, proteoglycans animal models. This review provides comprehensive overview molecular mechanisms involved also explores therapeutic potential different mitigating their protective effect inhibiting extracellular matrix (ECM) enhancing homeostasis.

Язык: Английский

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Apigenin-loaded nanoparticles for obesity intervention through immunomodulation and adipocyte browning

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113670 - 113670

Опубликована: Апрель 1, 2025

Язык: Английский

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Harnessing the nutriceutics in early-stage breast cancer: mechanisms, combinational therapy, and drug delivery

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 18, 2024

Breast cancer (BC) is a significant health challenge, ranking as the second leading cause of cancer-related death and primary mortality among women aged 45 to 55. Early detection crucial for optimal prognosis. Among various treatment options available cancer, chemotherapy remains predominant approach. However, its patient-friendliness hindered by cytotoxicity, adverse effects, multi-drug resistance, potential recurrence, high costs. This review explores extensively studied phytomolecules, elucidating their molecular mechanisms. It also emphasizes importance combination therapy, highlighting recent advancements in exploration diverse drug delivery systems novel routes administration. The regulatory considerations are translating these approaches into clinical practices.

Язык: Английский

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Potential Use of Selected Natural Compounds with Anti-Biofilm Activity

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 607 - 607

Опубликована: Янв. 13, 2025

Antibiotic resistance in microorganisms is an escalating global concern, exacerbated by their formation of biofilms, which provide protection through extracellular matrix and communication via quorum sensing, enhancing to treatment. This situation has driven the search for alternative approaches, particularly those using natural compounds. study explores potential phytochemicals, such as quercetin, apigenin, arbutin, gallic acid, proanthocyanidins, rutin, known antibacterial properties ability inhibit biofilm disrupt mature biofilms. The methods used this included a comprehensive review current literature assessing bioavailability, distribution, effective concentrations these compounds treating biofilm-associated infections. results indicate that phytochemicals exhibit significant effects, reduce biofilm’s structural integrity, bacterial pathways. Moreover, use combination with existing antibiotics may enhance therapeutic outcomes. findings support conclusion offer promising additions anti-biofilm strategies are capable complementing or replacing conventional treatments, appropriate levels delivery mechanisms being key effectiveness. insight underscores need further research into clinical applications infections complicated

Язык: Английский

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