Respiratory Flora Intervention: A New Strategy for the Prevention and Treatment of Occupationally Related Respiratory Allergy in Healthcare Workers DOI Creative Commons
Li Gao, Xi Chen,

Ziyi Jiang

и другие.

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2653 - 2653

Опубликована: Дек. 20, 2024

Occupational allergic respiratory disease in healthcare workers due to occupational exposure has received widespread attention. At the same time, evidence of altered flora associated with development allergy been found relevant epidemiologic studies. It is concern that composition nasopharyngeal differs significantly from non-healthcare factors, a particularly high prevalence carriage pathogenic and drug-resistant bacteria. Recent studies have interventions upper tract probiotics can reduce incidence allergies infections. We searched PubMed other databases describe burden this narrative review, we summarize mechanisms current state clinical research on use ameliorate allergy, aim providing new direction for protecting health workers.

Язык: Английский

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy DOI Creative Commons
Ruijing Zhang,

Runze Chang,

Heng Wang

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 4, 2025

Diabetic nephropathy (DN) is one of the major causes end-stage renal disease. This study aimed to explore internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics Olink proteomics. The serum 10 who were diagnosed healthy individuals Animal models used validate characterized genes. Correlation analysis differentially abundant metabolites expressed proteins revealed that SIRT2 might be a key hub linking energy metabolism innate immune responses. KEGG enrichment showed HIF-1 signaling pathway cell carcinoma co-enriched pathways inflammatory response. VEGFA plays vital role these two pathways. ability regulate expression has been demonstrated. In vivo experiments SIRT2, VEGFA, HIF-1α highly kidneys mice diabetic nephropathy. conclusion, our combines proteomics provide valuable insights into synergistic roles disorders DN. data suggest may target affecting processes.

Язык: Английский

Процитировано

0
Limosilactobacillus reuteri regulates gut microbiota and increases the effective metabolite luteolin to inhibit MAPK/STAT3 signaling pathway to alleviate allergic rhinitis DOI Creative Commons
Mingyan Zhang,

Xuewei Sun,

Xiang Yu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

The global prevalence of allergic rhinitis (AR) remains high, posing challenges due to its chronic nature and propensity for recurrence. Gut microbiota dysbiosis contributes immune dysregulation, impacting AR pathogenesis. Limosilactobacillus reuteri (L. reuteri) has great potential in regulating function alleviate symptoms. However, the specific active components mechanisms underlying therapeutic effects remain incompletely clarified. This study aimed explore L. metabolites alleviating AR. mouse model was constructed using ovalbumin (OVA). analysis hematoxylin-eosin staining (HE staining) enzyme-linked immunosorbent assay (ELISA) suggested that alleviated nasal inflammation, suppressed aberrant Th2 responses, modulated balance Treg Th17 cytokines. 16S rRNA sequencing untargeted metabolic revealed restored gut composition significantly increased abundance Ligilactobacillus metabolite luteolin (LO). Through ELISA Western blotting analysis, LO treatment Th1/Th2 Treg/Th17 cytokine MAPK/STAT3 signaling pathway mice. highlights as a key contributing anti-inflammatory reuteri, suggesting avenues future strategies management.

Язык: Английский

Процитировано

0
Preclinical Safety Assessment of the Oral Administration of Lactobacillus plantarum GUANKE in Animal Models DOI

Yuewen Yang,

Yanlin Zhang,

Ruixiang Sun

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
Time-course analysis of the effect of paraprobiotics ABG0050 on the intestinal immune system of broilers DOI Creative Commons
Hiroya Kondo,

S Iino,

Takako Fukuda

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105174 - 105174

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Administration of Lactobacillus plantarum GUANKE alleviates SARS-CoV-2-induced pneumonia in mice DOI Creative Commons
He Huang,

Xiaojing Dong,

Z.‐Q. Du

и другие.

Microbiology Spectrum, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets epithelial cells in the tract, triggering an proinflammatory response and chronic lung inflammation. Probiotic supplementation has shown promise reducing nasopharyngeal SARS-CoV-2 viral load, diminishing symptom frequency duration, mitigating inflammation; thus, it is a potential strategy for treating disease 2019 (COVID-19), which caused by infection. In this study, we evaluated effects of oral administration Lactobacillus plantarum GUANKE strain, gram-positive bacterium originally isolated from healthy individual, on infection human ACE2 transgenic mouse model. We found that significantly reduced inflammatory cell infiltration pulmonary interstitial exudation mice. The transcription CCL2 , TNFA IL1B IL6, IL17C lungs was reduced. protein levels TNF-α, IL-1β, IL-6, IL-17 were lower GUANKE-treated mice than control load saline-treated mice, although difference did not reach statistical significance. L. can decrease SARS-CoV-2-induced inflammation suggesting its use as agent IMPORTANCE Most otherwise individuals develop only mild or moderate symptoms (COVID-19) current strains severe (SARS-CoV-2), virus replication mainly confined to upper tract; however, infect tract promote been reduce overall number duration symptoms, attenuate clinical trials. showed novel strain alleviated pneumonia production cytokines suppressed, moderately load. become candidate drug treatment COVID-19 other infections.

Язык: Английский

Процитировано

1
Jingfang Granules alleviates OVA-induced allergic rhinitis through regulating endoplasmic reticulum stress signaling pathway DOI
Zhikang Wang,

Shujun Liu,

Shirong Li

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 119039 - 119039

Опубликована: Ноя. 5, 2024

Язык: Английский

Процитировано

0
Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial DOI Open Access
Lisa Lungaro,

Patrizia Malfa,

Francesca Manza

и другие.

Nutrients, Год журнала: 2024, Номер 16(23), С. 4173 - 4173

Опубликована: Ноя. 30, 2024

Allergic Rhinitis (AR) is an atopic disease affecting the upper airways of predisposed subjects exposed to aeroallergens. This study evaluates effects a mix specific probiotics (

Язык: Английский

Процитировано

0
Respiratory Flora Intervention: A New Strategy for the Prevention and Treatment of Occupationally Related Respiratory Allergy in Healthcare Workers DOI Creative Commons
Li Gao, Xi Chen,

Ziyi Jiang

и другие.

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2653 - 2653

Опубликована: Дек. 20, 2024

Occupational allergic respiratory disease in healthcare workers due to occupational exposure has received widespread attention. At the same time, evidence of altered flora associated with development allergy been found relevant epidemiologic studies. It is concern that composition nasopharyngeal differs significantly from non-healthcare factors, a particularly high prevalence carriage pathogenic and drug-resistant bacteria. Recent studies have interventions upper tract probiotics can reduce incidence allergies infections. We searched PubMed other databases describe burden this narrative review, we summarize mechanisms current state clinical research on use ameliorate allergy, aim providing new direction for protecting health workers.

Язык: Английский

Процитировано

0