Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 293, С. 117958 - 117958

Опубликована: Март 1, 2025

High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed independent, joint as well their interactions of metals OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD). Participants NAFLD from National Health Nutrition Examination Survey (NHANES) 1999-2018 were included. Mortality underlying causes death certain Death Index records through 31 December 2019. Cox regression models used to estimate hazard ratios (HRs) for all-cause disease-specific mortality. Additionally, we multiplicative additive Among 5263 patients NAFLD, 1097 deaths occurred during a mean follow-up 10.27 years. Compared those in tertile 1, participants 3 had lower risk (HR=0.79, 95 %CI: 0.64, 0.96). lowest lead concentration blood, highest an increased mortality, HRs (95 %CIs) being 1.23 (1.01, 1.51), 1.53(1.06, 2.20) 1.94(1.25, 3.01) all-cause, CVD cancer respectively. Similar results also found blood cadmium level. Joint associations analyses that low high-OBS HRs(95 0.58(0.40, 0.85), 0.45(0.21, 0.93) 0.35(0.15, 0.81), Multiplicative between (HR=0.87, 0.78, 0.97) (HR=0.81, 0.67, 0.99) found. exposure associated NAFLD. Adopting anti-oxidative lifestyle could harmful patients. Comprehensive strategies are essential decrease potentially overall burden

Язык: Английский

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Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 30, 2024

Background Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) an emerging composite assessment tool for dietary and lifestyle balance. We aimed explore association OBS CKD prevalence MetS this national cross-sectional analysis. Methods This was Eligible participants ≥20 years age from NHANES 1999–2018 were included. assessed according previous well-validated methods consisted 16 components 4 components. diagnosed by NCEP-ATP III criteria, while KDIGO 2021 Clinical Practice Guideline. Multivariate logistic regression models used Results A total 8,095 included, 24.8%. In fully adjusted models, each increases OBS, associated 2, 1.7, 7.3% reduction CKD, respectively. Higher all significantly lower odds ( p trend <0.05). Restricted cubic spline analysis showed that these associations exhibited inverse dose–response. Interaction analyses indicated cardiovascular (CVD) status influenced impact only present CVD-free subjects. Defining using IDF criteria did not change results. Conclusion inversely MetS, especially settings. These findings emphasize adherence antioxidant diet contributes early prevention population necessitates attention CVD interactions. Future prospective cohort studies are needed confirm

Язык: Английский

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Association of oxidative balance score, cardiovascular, and all-cause mortality among patients with type 2 diabetes mellitus

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 20, 2024

Background To investigate the association between oxidative balance score (OBS), cardiovascular mortality (CVM), and all-cause (ACM) in type 2 diabetes mellitus (T2DM) patients. Methods We included 6,119 participants with T2DM from 2005-2020 National Health Nutrition Examination Surveys (NHANES). The status of CVM ACM was followed through December 31, 2019. Multivariable Cox regression models, Kaplan-Meier curves, log-rank test, restricted cubic spline regression, subgroup analysis, were used to evaluate relationship OBS, CVM, ACM. Results During a median 100.9 months follow-up, 1,790 cases had occurred, 508 which due disease. divided into four groups based on quartiles OBS. Participants Q4 tended be younger, financially better-off, married, highly educated, lower alcohol consumption rates, non-smokers, exhibited likelihood CVM. In multivariate compared patients Q4, those Q1 30% increased risk for (Q1, reference; HR: 0.70, 95%CI: 0.58-0.86) 43% 0.57, 0.36-0.88). models have no nonlinear survival curves showed that (log-rank P < 0.05). Conclusions find increase higher OBS Moreover, there are linear relationships ACM,

Язык: Английский

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Interactive and Joint Effects of Heavy Metals and Oxidative Balance Score on the Risk of Mortality in Adults with Nafld

Опубликована: Янв. 1, 2024

Язык: Английский

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Association between Oxidative Balance Scores (OBS) and Gamma- Glutamyltransferase (GGT) among US adults in NHANES 2013– 2018

Опубликована: Ноя. 27, 2024

The Oxidative Balance Score (OBS) quantifies the balance between antioxidants and pro-oxidants, which is influenced by diet lifestyle, used to evaluate overall oxidative stress status. Elevated levels of γ-glutamyl transferase (GGT) are considered a primary indicator stress. This study aims explore association OBS GGT using data from National Health Nutrition Examination Survey (NHANES) conducted 2013 2018. A total 7,998 people were included in study. Research has revealed significant linear negative correlation was found scores GGT. Fully adjusted weighted logistic regression analysis showed that each unit increase associated with 3% decrease odds abnormal [OR = 0.97, 95%CI: 0.95, 0.99, P < 0.001]. By exploring this link, could provide valuable insights into developing preventive strategies interventions for abnormalities.

Язык: Английский

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