Association between oxidative balance score and all-cause, CVD and respiratory-related mortality in the US older adults of asthma patients with diabetes

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 15, 2025

This study aims to investigate the correlation between oxidative balance score (OBS) and all-cause, cardiovascular disease (CVD) respiratory-related mortality within a cohort that includes older asthma patients with diabetes. Data from National Health Nutrition Examination Survey (NHANES) spanning 2001 2018, which included 611 participants, were analyzed. Mortality outcomes determined by linking data Death Index (NDI) records through December 31, 2019. Cox regression modeling was employed examine relationship OBS CVD mortality. Restricted cubic splines (RCS), subgroup analyses interaction tests also conducted in this study. Over median follow-up of 78.96 months, there 216 all-cause deaths 57 CVD-related deaths. A significant negative association found We did not observe could reduce RCS analysis indicated linear inverse Subgroup significantly influenced alcohol consumption. In sample, higher associated lower risks. These findings stressed importance infection status assessing balance's impact on health.

Язык: Английский

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Association of oxidative balance scores with cardiovascular and all cause mortality in patients with asthma

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 31, 2025

Asthma poses significant societal costs, and a wholesome diet coupled with an energetic lifestyle might enhance postpartum results. Regrettably, empirical investigations into dietary aspects that amplify asthma risk remain scarce. The oxidative balance scores (OBS), quantifying stress from elements parameters, lack definitive link to overall cardiovascular mortality among asthmatic individuals. Data sourced NHANES (1999-2020) were utilized investigate the correlation between OBS index all-cause patients. Rigor was maintained through implementation of subgroup sensitivity analyses authenticate findings. study finally included 4,639 individuals mean age 42.55 years 43.46% males. Kaplan-Meier curves showed asthmatics lower quartiles had higher mortality. In fully adjusted Model 2, HR for in upper quartile 0.37 (95% CI: 0.26, 0.53), contrast asthmatics. Cardiovascular disease consistency (Q4, HR: 0.43, 95% 0.19, 0.98). association both patients remained stable across different models assessments. Restricted cubic spline linearly associated A analysis reinforced negative negatively correlated asthma, emphasizing protective effect antioxidant healthy asthma.

Язык: Английский

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Obesity, composite dietary antioxidant index, and their interactive association with the risk of cardiometabolic multimorbidity in the elderly from a large national survey

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 9, 2025

Dietary antioxidants and obesity are considered significant targets for disease prevention in the elderly. However, a possible cardiometabolic multimorbidity (CMM) correlated to dietary is unknown. This study aimed examine relationship between with CMM older population. We used data from NHANES 2003-2018 cycles, including adults aged 60 above. antioxidant status was assessed using CDAI, calculated six micronutrients (vitamins A, C, E, selenium, zinc, carotenoids), classified based on BMI. applied restricted cubic spline models explore nonlinear associations logistic regression assess pro-oxidant diet, obesity, CMM. The joint effects of diet were evaluated additive interaction indices: RERI, AP, SI, determine synergistic impact these factors. Subgroup analyses by age, sex, ethnicity, hypertension also conducted effect factors within different population groups. A total 13,178 (mean age 69.85 ± 0.10 years; 45.1% male) included this study. jointly increased risk, Pro-oxidant & Obese group having highest risk (adjusted OR 3.11, 95% CI: 2.39-4.04), indicating that their likelihood more than three times higher compared reference (Anti-oxidant Non-Obese group). Anti-oxidant 2.03, 1.59-2.59) 1.33, 1.08-1.64) showed elevated risks, although lesser extent. These findings suggest both independently contribute but combined pronounced. synergistic, RERI positive (0.75, 0.21, 1.29), AP showing 24% due interaction, SI greater (SI 1.55, 1.11-2.16). stronger interactions females, younger individuals, non-Hispanic Whites, those hypertension. Obesity pro-oxidative occurrence CMM; there exists an concerning initiation advancement studies revealed pronounced among adults, individuals

Язык: Английский

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Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 28, 2025

Background The oxidative balance score (OBS) combines diverse dietary components with lifestyle factors to comprehensively evaluate stress. investigation focuses on the link between OBS and mortality outcomes, including cardiovascular all-cause deaths, in overweight obese individuals. Methods analysis utilized data from National Health Nutrition Examination Survey (NHANES), covering period 1999 2018. Mortality information, categorized into was gathered Death Index (NDI). Kaplan–Meier survival analysis, along multivariate Cox regression restricted cubic spline (RCS) modeling, were explore risks. Subgroup sensitivity used assess robustness of results possible effect modifiers. Mediation identifies pathways through which independent variable affects dependent variable. Results In this study, 26,219 participants or obesity enrolled, an average age 49.8 ± 17.4 years. During a median follow-up duration 115 months, 2,239 (8.5%) died, 837 (3.2%) disease. According highest among lowest quartile (Q1) those (Q4). Participants fourth experienced 21.7% decrease risk all causes 29.5% risk, according fully adjusted results, compared first quartile. These validated subgroup analyses. RCS revealed notable inverse association outcomes. indicates that white blood cell count (WBC) gamma-glutamyl transferase (GGT) serve as significant mediators risk. Conclusion Elevated levels strongly linked reduced potential for both individuals who are obese.

Язык: Английский

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Association between oxidative balance score and lung function and FeNO and mortality in the US population

BMC Pulmonary Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 8, 2025

The Oxidative Balance Score (OBS) is a new indicator of overall antioxidant/oxidant balance that provides comprehensive picture the body's oxidative stress status, with higher OBS indicating greater antioxidant exposure. A limited number studies have examined association between and lung function FeNO, we aimed to investigate possible relationship FeNO. Data utilized in this study were sourced from 2007-2012 NHANES. Multivariable logistic regression was employed OBS/lifestyle (lifestyle antioxidants such as physical activity, etc., lifestyle pro-oxidants alcohol, smoking, etc.)/dietary (dietary fiber, β-carotene, riboflavin, dietary pro-oxidants, total fat, etc.) FEV1, FVC, PEF, FEF 25%- 75%, well obstructive ventilation dysfunction. dose-response FVC PEF explored using RCS analysis. Subgroup analysis interaction tests also conducted. We used multivariable Cox modeling explore OBS/dietary all-cause respiratory-related mortality. 8,568 participants enrolled. statistically significant observed levels. There no statistical OBS, FeNO revealed linear both FEV1 Notably, positive correlation more male participants. Conversely, levels influenced by gender BMI. effects on parameters independent whether had restrictive ventilatory dysfunction or dysfunction.In addition, demonstrated inverse associations mortality, whereas relationships these scores only exhibited In study, positively correlated (FEV1, PEF) U.S. adults. Exploring can enhance our understanding how homeostasis influences changes. This could provide valuable interventions for decline. found associated lower Adopting healthy consuming an antioxidant-rich diet may significantly improve prognosis patients reducing stress-related damage.

Язык: Английский

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Association of oxidative balance score, cardiovascular, and all-cause mortality among patients with type 2 diabetes mellitus

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 20, 2024

Background To investigate the association between oxidative balance score (OBS), cardiovascular mortality (CVM), and all-cause (ACM) in type 2 diabetes mellitus (T2DM) patients. Methods We included 6,119 participants with T2DM from 2005-2020 National Health Nutrition Examination Surveys (NHANES). The status of CVM ACM was followed through December 31, 2019. Multivariable Cox regression models, Kaplan-Meier curves, log-rank test, restricted cubic spline regression, subgroup analysis, were used to evaluate relationship OBS, CVM, ACM. Results During a median 100.9 months follow-up, 1,790 cases had occurred, 508 which due disease. divided into four groups based on quartiles OBS. Participants Q4 tended be younger, financially better-off, married, highly educated, lower alcohol consumption rates, non-smokers, exhibited likelihood CVM. In multivariate compared patients Q4, those Q1 30% increased risk for (Q1, reference; HR: 0.70, 95%CI: 0.58-0.86) 43% 0.57, 0.36-0.88). models have no nonlinear survival curves showed that (log-rank P < 0.05). Conclusions find increase higher OBS Moreover, there are linear relationships ACM,

Язык: Английский

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The relationship between oxidative balance score and circadian syndrome: evidence from the NHANES 2005-2018

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Окт. 11, 2024

Background The oxidative balance score (OBS) is a composite indicator that evaluates the between pro-oxidants and antioxidants in one’s diet lifestyle. However, relationship OBS circadian syndrome (CircS) has remained unexplored. This investigation aimed to determine correlation CircS. Methods population-based study examined 7,202 participants from 2005 2018 National Health Nutrition Examination Survey (NHANES), 1,433 of whom had We utilized weighted multivariate logistic regression, trend tests, subgroup analysis, interaction tests evaluate (total OBS, dietary lifestyle OBS) Restricted cubic splines (RCS) models threshold effect analysis were used explore nonlinear relationships. Results Multivariate regression indicated protective factor for CircS was high level OBS: Odds ratio (OR) = 0.95, 95% Confidence interval (CI): 0.93-0.97; OR 0.98, CI: 0.96-1.00; 0.65, 0.61-0.69). Compared quartile 1 group, negatively statistically significantly associated with risk developing Circs 4 group 0.47, 0.32-0.70; 0.69, 0.48-0.99; 0.07, 0.04-0.11). According there an association terms education ( p 0.01). Furthermore, we observed negative prevalence, inflection points at 6 nonlinearity 0.002). Conclusion results showed substantial connection Encouraging foods filled antioxidant-rich lifestyles may reduce

Язык: Английский

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Association between oxidative balance score and endometriosis findings from NHANES 1999–2006

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 19, 2024

Aim The Oxidative Balance Score (OBS) functions as a measure for gauging the oxidative stress condition, OBS has been utilized to assess overall oxidants and antioxidants exposure status in various chronic disease studies, Growing evidence suggests that is involved pathophysiologic mechanisms of endometriosis, purpose this study was investigate association between endometriosis women ages 20 54. Methods Results correlation meticulously examined through multifaceted approach, encompassing multivariate logistic regression, sensitivity analysis, application smoothing techniques curve fitting. This analysis conducted utilizing extensive dataset from National Health Nutrition Examination Survey (NHANES) spanning years 1999 2006. To ascertain stability observed relationship across diverse demographic segments, subgroup interaction tests were implemented. Among 3881 participants aged 54 years, significant inverse identified scores presence endometriosis. Specifically, within comprehensively adjusted model, every 1 score increase OBS, odds prevalence decreased by 2.00%. highest quartile demonstrated 29.1% reduction when compared those lowest quartile, with confidence interval [0.480, 1.048], underscoring robustness trend. Conclusions related among American adults. Our results suggest elevated may potentially reduce prevalence.

Язык: Английский

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Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999–2014

Journal of Geriatric Cardiology, Год журнала: 2024, Номер 21(8), С. 779 - 790

Опубликована: Авг. 1, 2024

Oxidative stress is closely associated with hypertensive outcomes. The oxidative balance score (OBS) measures exposure from dietary and lifestyle elements. objective of this study was to investigate the association between OBS mortality in patients.

Язык: Английский

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Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 16, 2024

Oxidative stress has an important role in type 2 diabetes (T2D). balance score (OBS) is emerging assessment of dietary and lifestyle oxidative balance. We aimed to explore the association OBS with cardiovascular disease (CVD) all-cause CVD mortality T2D population through NHANES 1999-2018.

Язык: Английский

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