Association between composite dietary antioxidant index and Epstein–Barr virus infection in children aged 6–19 years in the United States: from the national health and nutrition examination survey 2007–2010

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 3, 2025

Epstein-Barr virus (EBV) is a globally prevalent herpes associated with multiple diseases. Oxidative stress closely related to EBV infection, latency, reactivation, and transformation. Antioxidant diet protects against infection. Composite Dietary Index (CDAI), serving as key measure of antioxidant intake, summary score six dietary antioxidants, including vitamins A, C, E, carotenoid, selenium, zinc. Despite this, the association between CDAI infection remains uncertain. The aim study was evaluate using cross-sectional data from 3,318 children aged 6-19 years who participated in American National Health Nutrition Examination Survey 2007 2010. Data on results, CDAI, several other essential variables were analyzed. Compared that individuals Q3 (-1.627--0.2727) multivariate weighted logistic regression model full adjustment for confounding variables, adjusted odds ratio (OR) those Q1 (-6.613 - -2.9157), Q2 (-2.9158--1.626), Q4 (-0.2728-1.7601), Q5 (1.7602-21.419) 1.41 (95% CI: 1.01-1.96, p = 0.043), 1.10 0.84-1.45, 0.447), 1.14 0.86-1.51, 0.343), 1.01-1.98, 0.044), respectively. showed U-shaped curve (non-linear; 0.002). OR reducing 0.882 0.792-0.982, 0.025) participants ≤ 0.81. developing 1.055 1.000-1.114, 0.050) > Our results indicated U.S. adolescents follows curve, an inflection point around -0.81.This suggests antioxidant-rich some amount could help reduce risk Future prospective experimental studies are needed confirm causality clarify exact mechanism concerning diets

Язык: Английский

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A meta‐analysis to study the effects and relationships of various selenium sources and forms on production performance, antioxidant status and egg quality of laying hens

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Abstract BACKGROUND Nowadays, there is increasing interest in optimizing the beneficial effects on egg quality and production by investigating various levels sources of Se. METHODS Data forms, Se were analyzed using a meta‐analysis approach terms their production, antioxidant activity deposition laying hens 81 peer‐reviewed publications. RESULTS Overall, hens' performance attributes not affected supplementation, except for minor changes weight eggshell thickness response to higher diets. Noticeable found activities where organic outperformed inorganic form. Strong linear relationships between diet content whole egg, yolk albumen form selenomethionine (SM) exhibited stronger relationship with ( R 2 = 0.954), 0.972) 0.926) than other forms (sodium selenite). Also observed was preferential compared especially SM, indicating bioavailability rate SM sources. CONCLUSION Various could be safely supplemented diets at high doses up 5 mg kg −1 without adversely affecting while enhancing status. Supplementation most effective strategy improve status among which may consumers. © 2025 Society Chemical Industry.

Язык: Английский

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Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117989 - 117989

Опубликована: Март 1, 2025

Glyphosate and glyphosate-based herbicides (GBHs), extensively used worldwide, have been associated with various health concerns, including an elevated risk of mortality. Experimental studies suggest that these may disrupt selenium homeostasis by hindering its uptake or promoting oxidative stress. However, the interplay between glyphosate exposure status remains poorly understood in epidemiological studies, particularly regarding selenium's role modulating mortality nationally representative populations. In this study, we analyzed data from 2013-2018 National Health Nutrition Examination Survey (NHANES), which included 6410 participants aged 3 years older. This dataset was linked to information Center for Statistics (NCHS) individuals 18 older, follow-up through 2019. The primary aim investigate relationships urinary levels, whole blood selenium, intake, influence on glyphosate-related all-cause risk. A significant negative correlation observed natural logarithm (ln) levels ln complex multiple linear regression models, a ß coefficient -0.010 (SE = 0.003, P 0.003). no association found intake. Furthermore, prominent among females, non-Hispanic whites, lower When examining relationship exposure, mortality, higher ln-urinary were significantly increased (Hazard Ratio [HR] 1.43; 95 % CI: 1.00-2.09). especially pronounced concentrations at above 50th percentile. Additionally, ln-whole protective effect against (HR 0.01; 0.00-0.18), strongest below comprehensive analysis NHANES data, our study identifies potentially harmful levels. Notably, excessively high not only reduce effects but could also increase suggesting U-shaped These findings highlight need further research into interaction status, emphasizing potential public implications.

Язык: Английский

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Genetically Elevated Selenoprotein S Levels and Risk of Stroke: A Two-Sample Mendelian Randomization Analysis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1652 - 1652

Опубликована: Фев. 14, 2025

Selenoprotein S (SELENOS), one of the carrier proteins dietary selenium (Se), is a key regulator inflammation, oxidative stress, and endoplasmic reticulum (ER) all which are implicated in pathogenesis stroke. However, causality between SELENOS stroke risk remains poorly understood. This study aimed to explore association genetically determined plasma levels all-cause stroke, ischemic intracerebral hemorrhage (ICH) using two-sample Mendelian randomization (MR) approach. We analyzed data from three large-scale Genome-Wide Association Study (GWAS) meta-analyses individuals European descent. The fixed-effect inverse-variance weighted (IVW) model analysis revealed that elevated were associated with an increased ICH. Sensitivity analyses showed no evidence pleiotropy or heterogeneity, leave-one-out confirmed robustness our results. Here, we show causally linked risk. Although effect sizes modest, these findings suggest may play role pathogenesis, emphasizing need for further mechanistic functional studies. Finally, shed light on importance tailored Se intake management context prevention.

Язык: Английский

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Dietary Intakes of Copper and Selenium in Association with Bone Mineral Density

Nutrients, Год журнала: 2024, Номер 16(16), С. 2777 - 2777

Опубликована: Авг. 20, 2024

The important trace elements, copper and selenium, have diverse effects on human health. As well as other roles in living tissues, these elements are toxic at high levels but key constituents of various enzymes proteins essential for maintaining physiological However, links between dietary intakes particularly copper, bone mineral density (BMD) humans remain uncertain. This study aimed to investigate whether selenium associated with BMD women. Dietary were assessed 575 women the Geelong Osteoporosis Study, using a detailed semi-quantitative food frequency questionnaire conjunction nutrition composition databases. Participants taking oral multivitamin preparations excluded from analyses; 522 participants (ages 20-88 y) met eligibility criteria. multiple skeletal sites was measured by dual energy X-ray absorptiometry (Lunar DPX-L). Separate multivariable regression models developed identify associations BMD, after adjustments age, anthropometry, factors, medication use, lifestyle factors. Median (interquartile range) daily intake 1.5 mg (1.2-1.9) 72 μg (57-90). Low (lowest tertile versus pooled upper tertiles) consistently lower sites. Fully adjusted identified small statistically significant differences ranging 1.8% 4.0% low 1.4% intakes. both independently least this sample results contribute evidence base informing recommendations respect their contributions optimal

Язык: Английский

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Erythrocyte Selenium as a Potential Key Indicator for Selenium Supplementation in Low-Selenium Populations: A Selenium Supplementation Study Based on Wistar Rats

Nutrients, Год журнала: 2024, Номер 16(22), С. 3797 - 3797

Опубликована: Ноя. 5, 2024

Selenium (Se) is an essential trace element for maintaining human health, with significant antioxidant and immunoregulatory functions. Inadequate Se intake may be associated Keshan disease, Kashin-Beck hypothyroidism. However, effective indicators scientifically guiding supplementation in Se-deficient populations are still lacking.

Язык: Английский

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