Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 23, 2025
Importance
Oxidative
stress
contributes
to
the
progression
of
non-alcoholic
fatty
liver
disease
(NAFLD).
Antioxidants
from
food
can
reduce
NAFLD
incidence,
and
Composite
Dietary
Antioxidant
Index
(CDAI)
measures
total
antioxidant
capacity
(TAC).
However,
relationship
between
CDAI
in
US
adult
population
remains
unclear.
Objective
To
assess
whether
is
associated
with
adults.
Design,
setting,
participants
This
population-based
cross-sectional
study
used
data
on
adults
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2016
cycles.
Data
were
analyzed
January
February
2024.
Exposures
obtained
dietary
intake
questionnaire.
Main
outcomes
The
main
outcome
was
which
defined
by
score
(USFLI)
≥30.
Sampling
weights
calculated
according
NHANES
guidelines.
Results
Among
9,746
included
this
[mean
age,
48.3
years;
4,662
(47.6%)
males],
3,324
(33.0%)
classified
as
having
using
USFLI.
In
fully
adjusted
multivariable
logistic
regression,
negatively
(odds
ratio
[OR],
0.95;
95%
CI,
0.93–0.98).
Furthermore,
individuals
highest
quartile
34%
less
likely
have
compared
those
lowest
(OR,
0.66;
0.52–0.85).
subgroup
analyses,
inversely
among
a
BMI
<25
0.89;
0.83–0.95)
without
metabolic
syndrome
0.93;
0.91–0.96).
interaction
tests
revealed
significant
differences
these
subgroups
(
P
for
=
0.04
0.003
syndrome).
Sensitivity
analyses
confirmed
association
hepatic
steatosis
index
(HSI)
define
NAFLD,
applying
unweighted
adjusting
physical
activity
or
after
excluding
non-Hispanic
Black
participants,
medications
known
their
potential
hepatotoxic
effects.
Conclusions
relevance
based
six
cycles
(2005–2016)
NHANES,
population.
highlights
interventions
incidence
underscores
need
future
research,
including
clinical
trials
mechanistic
studies,
further
explore
role
antioxidants
prevention
management.
Язык: Английский
The Composite Dietary Antioxidant Index is Associated With Common Non-communicable Diseases: The Mediation and Joint Effects of Inflammatory Indices
Biological Research For Nursing,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Purpose:
To
evaluate
the
associations
between
composite
dietary
antioxidant
index
(CDAI)
and
common
non-communicable
diseases
(NCDs)
explore
potential
effects
of
inflammatory
indices
in
these
associations.
Methods:
We
included
20,097
adults
from
National
Health
Nutrition
Examination
Survey
2003-2018.
Multivariable
logistic
regressions
were
applied
to
CDAI
NCDs.
Mediation
analysis
was
used
role
Results:
Higher
associated
with
a
downward
trend
incidence
obesity,
cardiovascular
disease
(CVD),
chronic
respiratory
diseases,
kidney
(CKD)
(p
for
<
0.05).
The
association
CVD
influenced
by
C-reactive
protein
(CRP),
red
blood
cell
width
(RDW),
neutrophil
lymphocyte
ratio
(NLR),
mediated
proportions
3.490%,
5.173%,
2.351%,
respectively.
NLR
partially
contributed
link
CKD,
mediating
2.746%.
Additionally,
we
observed
additive
interactions
CRP
(RERI
(95%
CI):
0.282
(0.070,
0.494),
AP
0.539
(0.088,
0.991),
as
well
RDW
on
0.318
(0.124,
0.511),
0.717
(0.217,
1.218)).
There
also
appeared
be
weak
multiplicative
interaction
(p-int
=
0.049).
Conclusion:
Our
investigation
ascertained
that
related
Moreover,
played
an
important
Язык: Английский