Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis
Journal of Investigative Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits
Biology,
Год журнала:
2025,
Номер
14(2), С. 143 - 143
Опубликована: Янв. 30, 2025
Melatonin
is
indispensable
for
the
homeostasis
of
plants
and
animals.
In
humans,
it
can
help
prevent
or
be
an
adjuvant
treatment
several
diseases
mainly
related
to
immune
system,
inflammation,
oxidative
stress.
Moreover,
a
melatonin-rich
diet
linked
health
benefits,
such
as
regulation
circadian
rhythm,
immunological
epilepsy
control,
delaying
aging
process,
diminishing
hormones
cancer.
This
review
aimed
show
effects
melatonin
in
beyond
its
traditional
use.
The
results
showed
present
scavenging
free
radicals,
reducing
inflammatory
cytokines,
modulating
system.
improve
insulin
resistance,
blood
pressure,
LDL-c,
adipose
tissue
mass,
adhesion
molecules,
endothelial
impairment,
plaque
formation.
These
result
neuro-
cardioprotection,
improvement
liver
diseases,
rheumatoid
arthritis,
dermatitis,
COVID-19,
polycystic
ovaries,
sepsis.
We
conclude
that
plant
benefit
patients
with
many
besides
sleep
problems
neurodegeneration.
Plant
may
more
cost-effective
fewer
adverse
events
than
synthetic.
However,
clinical
trials
should
performed
adequate
doses,
formulation,
time.
Язык: Английский
Challenges in diagnosis and treatment of pediatric psoriasis and atopic dermatitis
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Фев. 12, 2025
Язык: Английский
Exploring mechanisms of skin aging: insights for clinical treatment
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 8, 2024
The
skin
is
the
largest
organ
in
human
body
and
made
up
of
various
cells
structures.
Over
time,
will
age,
which
not
only
influenced
by
internal
factors,
but
also
external
environmental
especially
ultraviolet
radiation.
Aging
causes
immune
system
weakening
elderly,
makes
them
more
susceptible
to
dermatosis,
such
as
type
2
inflammatory
mediated
pruritus.
response
this
condition
marked
senescent
consistently
releasing
low
amounts
pro-inflammatory
cytokines
through
a
senescence-associated
secretory
phenotype
(SASP).
This
continuous
inflammation
may
accelerate
aging
establish
connection
between
diseases.
In
addition,
two
chronic
pigmentation
disorders,
vitiligo
chloasma,
are
associated
with
aging.
Aged
escape
accumulate
tissues,
forming
microenvironment
that
promotes
cancer.
At
same
"photoaging"
caused
excessive
exposure
radiation
an
important
cause
manuscript
describes
possible
links
inflammation,
cancer
suggests
some
treatment
options.
Язык: Английский
The influence of phototherapy on circadian melatonin and sleep regulation and potential benefits of these pathways in the management of vitiligo: a narrative review
Archives of Dermatological Research,
Год журнала:
2024,
Номер
316(9)
Опубликована: Сен. 21, 2024
Язык: Английский
Unveiling ferroptosis: a new frontier in skin disease research
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 4, 2024
Ferroptosis,
a
form
of
regulated
cell
death
distinct
from
apoptosis,
necrosis,
and
autophagy,
is
increasingly
recognized
for
its
role
in
skin
disease
pathology.
Characterized
by
iron
accumulation
lipid
peroxidation,
ferroptosis
has
been
implicated
the
progression
various
conditions,
including
psoriasis,
photosensitive
dermatitis,
melanoma.
This
review
provides
an
in-depth
analysis
molecular
mechanisms
underlying
compares
cellular
effects
with
other
forms
context
health
disease.
We
systematically
examine
five
specific
diseases,
ichthyosis,
polymorphous
light
eruption
(PMLE),
vitiligo,
melanoma,
detailing
influence
on
pathogenesis
progression.
Moreover,
we
explore
current
clinical
landscape
ferroptosis-targeted
therapies,
discussing
their
potential
managing
treating
diseases.
Our
aim
to
shed
therapeutic
modulating
research
practice.
Язык: Английский