Association between composite dietary antioxidant index and Epstein–Barr virus infection in children aged 6–19 years in the United States: from the national health and nutrition examination survey 2007–2010

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 3, 2025

Epstein-Barr virus (EBV) is a globally prevalent herpes associated with multiple diseases. Oxidative stress closely related to EBV infection, latency, reactivation, and transformation. Antioxidant diet protects against infection. Composite Dietary Index (CDAI), serving as key measure of antioxidant intake, summary score six dietary antioxidants, including vitamins A, C, E, carotenoid, selenium, zinc. Despite this, the association between CDAI infection remains uncertain. The aim study was evaluate using cross-sectional data from 3,318 children aged 6-19 years who participated in American National Health Nutrition Examination Survey 2007 2010. Data on results, CDAI, several other essential variables were analyzed. Compared that individuals Q3 (-1.627--0.2727) multivariate weighted logistic regression model full adjustment for confounding variables, adjusted odds ratio (OR) those Q1 (-6.613 - -2.9157), Q2 (-2.9158--1.626), Q4 (-0.2728-1.7601), Q5 (1.7602-21.419) 1.41 (95% CI: 1.01-1.96, p = 0.043), 1.10 0.84-1.45, 0.447), 1.14 0.86-1.51, 0.343), 1.01-1.98, 0.044), respectively. showed U-shaped curve (non-linear; 0.002). OR reducing 0.882 0.792-0.982, 0.025) participants ≤ 0.81. developing 1.055 1.000-1.114, 0.050) > Our results indicated U.S. adolescents follows curve, an inflection point around -0.81.This suggests antioxidant-rich some amount could help reduce risk Future prospective experimental studies are needed confirm causality clarify exact mechanism concerning diets

Язык: Английский

Obesity, composite dietary antioxidant index, and their interactive association with the risk of cardiometabolic multimorbidity in the elderly from a large national survey

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 9, 2025

Dietary antioxidants and obesity are considered significant targets for disease prevention in the elderly. However, a possible cardiometabolic multimorbidity (CMM) correlated to dietary is unknown. This study aimed examine relationship between with CMM older population. We used data from NHANES 2003-2018 cycles, including adults aged 60 above. antioxidant status was assessed using CDAI, calculated six micronutrients (vitamins A, C, E, selenium, zinc, carotenoids), classified based on BMI. applied restricted cubic spline models explore nonlinear associations logistic regression assess pro-oxidant diet, obesity, CMM. The joint effects of diet were evaluated additive interaction indices: RERI, AP, SI, determine synergistic impact these factors. Subgroup analyses by age, sex, ethnicity, hypertension also conducted effect factors within different population groups. A total 13,178 (mean age 69.85 ± 0.10 years; 45.1% male) included this study. jointly increased risk, Pro-oxidant & Obese group having highest risk (adjusted OR 3.11, 95% CI: 2.39-4.04), indicating that their likelihood more than three times higher compared reference (Anti-oxidant Non-Obese group). Anti-oxidant 2.03, 1.59-2.59) 1.33, 1.08-1.64) showed elevated risks, although lesser extent. These findings suggest both independently contribute but combined pronounced. synergistic, RERI positive (0.75, 0.21, 1.29), AP showing 24% due interaction, SI greater (SI 1.55, 1.11-2.16). stronger interactions females, younger individuals, non-Hispanic Whites, those hypertension. Obesity pro-oxidative occurrence CMM; there exists an concerning initiation advancement studies revealed pronounced among adults, individuals

Язык: Английский