Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
The
gut
microbiota,
a
complex
microbial
ecosystem
closely
connected
to
the
liver
via
portal
vein,
has
emerged
as
critical
regulator
of
health
and
disease.
Numerous
studies
have
underscored
its
role
in
onset
progression
disorders,
including
alcoholic
disease,
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
steatohepatitis
(MASH),
fibrosis,
cirrhosis,
hepatocellular
carcinoma
(HCC).
This
review
provides
comprehensive
overview
current
insights
into
influence
microbiota
on
HCC
progression,
particularly
effects
immune
cells
within
tumor
microenvironment
(TME).
Furthermore,
we
explore
potential
microbiota-targeted
interventions,
such
antibiotics,
probiotics,
prebiotics,
fecal
transplantation
(FMT),
modulate
response
improve
outcomes
immunotherapy
HCC.
By
synthesizing
from
recent
studies,
this
aims
highlight
microbiota-based
strategies
that
may
enhance
outcomes,
advancing
personalized
approaches
treatment.
Язык: Английский
Heat exposure promotes sarcopenia via gut microbiota‐derived metabolites
Aging Cell,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Abstract
The
unprecedented
rise
in
global
ambient
temperatures
the
last
decade
has
significantly
impacted
human
health,
yet
how
heat
exposure
affects
development
of
sarcopenia
remains
enigmatic.
Here,
we
demonstrate
that
chronic
induces
skeletal
muscle
volume
loss,
leading
to
strength
and
functional
decline
mice.
microbiota
composition
heat‐exposed
mice
was
analyzed
using
16S
ribosomal
DNA
analysis.
Liquid
chromatography‐mass
spectrometry
(LC–MS)
used
explore
effects
on
blood
metabolome
further
analyze
correlation
between
metabolism
gut
microbiota.
Transplantation
from
germ‐free
sufficient
increase
adverse
function
host.
Mechanistically,
an
untargeted
metabolomics
strategy,
reveal
altered
due
high
is
associated
with
elevated
serum
levels
homocitrulline.
Homocitrulline
causes
mitochondrial
dysfunction
myocytes
by
exacerbating
ferroptosis
levels.
And
Nrf2
activator
(Oltipraz)
supplementation
alleviates
atrophy
induced
exposure.
Our
findings
detrimental
provide
new
strategies
for
treating
sarcopenia.
Язык: Английский
The Relationship Between Gut Microbiota, Muscle Mass and Physical Function in Older Individuals: A Systematic Review
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 81 - 81
Опубликована: Дек. 28, 2024
Background:
Recent
evidence
suggests
that
sarcopenia
and
subsequent
changes
in
muscle
mass
functional
outcomes
are
linked
to
disruption
the
gastrointestinal
microbiota
composition
and/or
function
via
microbiota-gut-muscle
axis.
Despite
growing
interest,
few
studies
have
systemically
analysed
(1)
relationship
between
gut
microbiota,
physical
performance
(2)
effects
of
gut-modulating
dietary
interventions
on
these
within
older
individuals
with
or
without
sarcopenia.
Methods:
Four
electronic
databases
(PubMed,
MEDLINE,
Embase
Scopus)
were
searched
for
articles
published
from
year
2004
until
July
2023.
The
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
followed.
Revised
Cochrane
Risk
Bias
(RoB
2.0)
Joanna
Briggs
Institute
(JBI)
critical
appraisal
checklist
utilised
evaluate
risk
bias
intervention
observational
studies,
respectively.
Results:
A
total
20
(14
6
interventional)
involving
4071
participants
(mean
age
69.9
years,
51.6%
female)
included.
There
was
significant
heterogeneity
regarding
outcome
measures
used
studies.
Correlations
diversity
sarcopenia-related
observed.
Interventional
targeting
resulted
improved
strength,
body
some,
but
not
all,
Conclusions:
limitations
reviewed,
findings
provide
further
development
is
likely
influenced
by
an
altered
microbial
environment
microbiome
could
hold
therapeutic
potential
treatment
management
Язык: Английский
Effect of Isoflavone on Muscle Atrophy in Ovariectomized Mice
Nutrients,
Год журнала:
2024,
Номер
16(19), С. 3295 - 3295
Опубликована: Сен. 28, 2024
Background:
Sarcopenia,
characterized
by
muscle
mass
decline
due
to
aging
or
other
causes,
is
exacerbated
decreased
estrogen
levels
after
menopause
in
women.
Isoflavones,
a
class
of
flavonoids
acting
on
receptors,
may
have
beneficial
effects
metabolic
disorders.
We
examined
these
ovariectomized
mice
fed
high-fat,
high-sucrose
diet
(HFHSD).
Methods:
At
7
weeks
old,
female
C57BL6/J
(18–20
g,
n
=
12)
underwent
bilateral
ovariectomy
(OVX),
and
were
then
starting
at
8
age.
Half
the
received
isoflavone
water
(0.1%).
Metabolic
analyses,
including
glucose
insulin
tolerance
tests,
conducted.
Muscle
analysis
involved
grip
strength
assays,
next-generation
sequencing,
quantitative
RT–PCR,
western
blotting
skeletal
euthanizing
14
old.
Additionally,
16S
rRNA
gene
sequence
gut
microbiota
was
performed.
Results:
The
results
demonstrated
that
administration
did
not
affect
body
weight,
tolerance,
lipid
metabolism.
In
contrast,
isoflavone-treated
had
higher
strength.
Gene
expression
soleus
revealed
Trim63
expression,
showed
inactivation
muscle-specific
RING
finger
protein
1
mice.
Gut
indicated
Bacteroidetes
lower
Firmicutes
abundance
group,
along
with
increased
diversity.
sets
related
TNF-α
signaling
via
NF-κB
unfolded
response
negatively
associated
isoflavones.
Conclusions:
Isoflavone
intake
alters
increases
strength,
suggesting
potential
role
improving
sarcopenia
menopausal
Язык: Английский